ROC evaluation of SPECT myocardial lesion detectability with and without single itération non-uniform chang atténuation compensation using an anthropomorphic female phantom

Sunyoung Jangl, Ronald J. Jaszczak, M. W. Benjamin, Charles E. Metz, David R. Gilland, Timothy G. Turkington, R. Edward Coleman

Research output: Contribution to journalArticle

Abstract

The purpose of this work was to evaluate lesion detectability with and without nonuniform attenuation compensation (AC) in myocardial perfusion SPECT imaging in women using an anthropomorphic phantom and receiver operating characteristics (ROC) methodology. Breast attenuation causes artifacts in reconstructed images and may increase the difficulty of diagnosis of myocardial perfusion imaging in women. The null hypothesis tested using the ROC study was that nonuniform AC does not change the lesion detectability in myocardial perfusion SPECT imaging in women. We used a filtered backprojection (EBP) reconstruction algorithm and Chang's single iteration method for AC. In conclusion, with our proposed myocardial defect model nuclear medicine physicians demonstrated no significant difference for the detection of the anterior wall defect; however, a greater accuracy for the detection of the inferior wall defect was observed without nonuniform AC than with it (Pvalue = 0.0034). Medical physicists did not demonstrate any statistically significant difference in defect detection accuracy with or without nonuniform AC in the female phantom.

Original languageEnglish (US)
Pages (from-to)2080-2088
Number of pages9
JournalIEEE Transactions on Nuclear Science
Volume45
Issue number4 PART 2
DOIs
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'ROC evaluation of SPECT myocardial lesion detectability with and without single itération non-uniform chang atténuation compensation using an anthropomorphic female phantom'. Together they form a unique fingerprint.

  • Cite this