Robust trend tests for genetic association using matched case-control design

Gang Zheng, Xin Tian, Steven E. Weinberger, Patricia Finn, Erik Garpestad, Allison Moran, Henry Yeager, David L. Rabin, Susan Stein, Michael C. Iannuzzi, Benjamin A. Rybicki, Marcie Major, Mary Maliarik, John Popovich, David Moller, Carol J. Johns, Cynthia S Rand, Joanne Steimel, Marc A. Judson, Susan D. Alessandro & 79 others Nancy Heister, Theresa Johnson, Daniel T. Lackland, Janardan Pandey, Steven Sahn, Charlie Strange, Alvin S. Teirstein, Louis DePalo, Sheldon Brown, Marvin Lesser, Maria L. Padilla, Marilyn Marshall, Lee S. Newman, Cecile Rose, Juli Barnard, Robert P. Baughman, Elysc E. Lower, Donna B. Winget, Geoffrey McLennan, Gary Hunninghake, Chuck Dayton, Linda Powers, Milton D. Rossman, Eddy A. Bresnitz, Ronald Daniele, Jackie Regovich, William Sexauer, Robert Musson, Joanne Deshler, Paul Sorlie, Margaret Wu, Reuben Cherniak, Lee Newman, Genell L. Knatterud, Michael L. Terrin, Bruce W. Thompson, Kathleen Brown, Margaret Frederick, Frances LoPresti, Patricia Wilkins, Martha Canner, Judy Dotson, Steve Lindenfelser, Mark Cosentino, Mary Maliarik, Robert Baughman, Milton Rossman, Dimitri Monos, Chung Wha Lee, David Moller, Janardan Pandey, Peter Almenoff, Ian Brett, Sheldon Brown, Marvin Lesser, Lee Newman, Brian Kotzin, Geoffrey McLennan, Gary Hunninghake, Patricia Finn, Richard D. Jaffe, Reuben Cherniack, Robert P. Baughman, Joanne Deshler, Michael C. Iannuzzi, Marc A. Judson, Genell L. Knatterud, Geoffrey McLennan, David R. Moller, Robert A. Musson, Lee S. Newman, Milton D. Rossman, Alvin S. Teirstein, Michael L. Terrin, William Martin, Takamaru Ashikaga, David B. Coultas, Gerald S. Davis, Fred Gifford

Research output: Contribution to journalArticle

Abstract

Trend tests for genetic association using a matched case-control design are studied, which allows for a variable number of controls per case. However, the tests depend on the scores based on the underlying genetic model, thus it may result in substantial loss of power when the model is misspecified. Since the mode of inheritance may be unknown for complex diseases, robust trend tests in matched case-control studies are developed. Simulation is conducted to compare the trend tests and the robust trend tests under various genetic models. The results are applied to detect candidate-gene association using an example from a case-control aetiologic study of sarcoidosis.

Original languageEnglish (US)
Pages (from-to)3160-3173
Number of pages14
JournalStatistics in Medicine
Volume25
Issue number18
DOIs
StatePublished - Sep 30 2006

Fingerprint

Trend Test
Genetic Association
Robust Tests
Case-control
Genetic Models
Control Design
Case-Control Studies
Sarcoidosis
Matched Case-control Study
Case-control Study
Genes
Model
Gene
Unknown
Simulation

Keywords

  • Case-control study
  • MAX
  • MERT
  • Score test
  • Variable matching

ASJC Scopus subject areas

  • Epidemiology

Cite this

Zheng, G., Tian, X., Weinberger, S. E., Finn, P., Garpestad, E., Moran, A., ... Gifford, F. (2006). Robust trend tests for genetic association using matched case-control design. Statistics in Medicine, 25(18), 3160-3173. https://doi.org/10.1002/sim.2278

Robust trend tests for genetic association using matched case-control design. / Zheng, Gang; Tian, Xin; Weinberger, Steven E.; Finn, Patricia; Garpestad, Erik; Moran, Allison; Yeager, Henry; Rabin, David L.; Stein, Susan; Iannuzzi, Michael C.; Rybicki, Benjamin A.; Major, Marcie; Maliarik, Mary; Popovich, John; Moller, David; Johns, Carol J.; Rand, Cynthia S; Steimel, Joanne; Judson, Marc A.; Alessandro, Susan D.; Heister, Nancy; Johnson, Theresa; Lackland, Daniel T.; Pandey, Janardan; Sahn, Steven; Strange, Charlie; Teirstein, Alvin S.; DePalo, Louis; Brown, Sheldon; Lesser, Marvin; Padilla, Maria L.; Marshall, Marilyn; Newman, Lee S.; Rose, Cecile; Barnard, Juli; Baughman, Robert P.; Lower, Elysc E.; Winget, Donna B.; McLennan, Geoffrey; Hunninghake, Gary; Dayton, Chuck; Powers, Linda; Rossman, Milton D.; Bresnitz, Eddy A.; Daniele, Ronald; Regovich, Jackie; Sexauer, William; Musson, Robert; Deshler, Joanne; Sorlie, Paul; Wu, Margaret; Cherniak, Reuben; Newman, Lee; Knatterud, Genell L.; Terrin, Michael L.; Thompson, Bruce W.; Brown, Kathleen; Frederick, Margaret; LoPresti, Frances; Wilkins, Patricia; Canner, Martha; Dotson, Judy; Lindenfelser, Steve; Cosentino, Mark; Maliarik, Mary; Baughman, Robert; Rossman, Milton; Monos, Dimitri; Lee, Chung Wha; Moller, David; Pandey, Janardan; Almenoff, Peter; Brett, Ian; Brown, Sheldon; Lesser, Marvin; Newman, Lee; Kotzin, Brian; McLennan, Geoffrey; Hunninghake, Gary; Finn, Patricia; Jaffe, Richard D.; Cherniack, Reuben; Baughman, Robert P.; Deshler, Joanne; Iannuzzi, Michael C.; Judson, Marc A.; Knatterud, Genell L.; McLennan, Geoffrey; Moller, David R.; Musson, Robert A.; Newman, Lee S.; Rossman, Milton D.; Teirstein, Alvin S.; Terrin, Michael L.; Martin, William; Ashikaga, Takamaru; Coultas, David B.; Davis, Gerald S.; Gifford, Fred.

In: Statistics in Medicine, Vol. 25, No. 18, 30.09.2006, p. 3160-3173.

Research output: Contribution to journalArticle

Zheng, G, Tian, X, Weinberger, SE, Finn, P, Garpestad, E, Moran, A, Yeager, H, Rabin, DL, Stein, S, Iannuzzi, MC, Rybicki, BA, Major, M, Maliarik, M, Popovich, J, Moller, D, Johns, CJ, Rand, CS, Steimel, J, Judson, MA, Alessandro, SD, Heister, N, Johnson, T, Lackland, DT, Pandey, J, Sahn, S, Strange, C, Teirstein, AS, DePalo, L, Brown, S, Lesser, M, Padilla, ML, Marshall, M, Newman, LS, Rose, C, Barnard, J, Baughman, RP, Lower, EE, Winget, DB, McLennan, G, Hunninghake, G, Dayton, C, Powers, L, Rossman, MD, Bresnitz, EA, Daniele, R, Regovich, J, Sexauer, W, Musson, R, Deshler, J, Sorlie, P, Wu, M, Cherniak, R, Newman, L, Knatterud, GL, Terrin, ML, Thompson, BW, Brown, K, Frederick, M, LoPresti, F, Wilkins, P, Canner, M, Dotson, J, Lindenfelser, S, Cosentino, M, Maliarik, M, Baughman, R, Rossman, M, Monos, D, Lee, CW, Moller, D, Pandey, J, Almenoff, P, Brett, I, Brown, S, Lesser, M, Newman, L, Kotzin, B, McLennan, G, Hunninghake, G, Finn, P, Jaffe, RD, Cherniack, R, Baughman, RP, Deshler, J, Iannuzzi, MC, Judson, MA, Knatterud, GL, McLennan, G, Moller, DR, Musson, RA, Newman, LS, Rossman, MD, Teirstein, AS, Terrin, ML, Martin, W, Ashikaga, T, Coultas, DB, Davis, GS & Gifford, F 2006, 'Robust trend tests for genetic association using matched case-control design', Statistics in Medicine, vol. 25, no. 18, pp. 3160-3173. https://doi.org/10.1002/sim.2278
Zheng G, Tian X, Weinberger SE, Finn P, Garpestad E, Moran A et al. Robust trend tests for genetic association using matched case-control design. Statistics in Medicine. 2006 Sep 30;25(18):3160-3173. https://doi.org/10.1002/sim.2278
Zheng, Gang ; Tian, Xin ; Weinberger, Steven E. ; Finn, Patricia ; Garpestad, Erik ; Moran, Allison ; Yeager, Henry ; Rabin, David L. ; Stein, Susan ; Iannuzzi, Michael C. ; Rybicki, Benjamin A. ; Major, Marcie ; Maliarik, Mary ; Popovich, John ; Moller, David ; Johns, Carol J. ; Rand, Cynthia S ; Steimel, Joanne ; Judson, Marc A. ; Alessandro, Susan D. ; Heister, Nancy ; Johnson, Theresa ; Lackland, Daniel T. ; Pandey, Janardan ; Sahn, Steven ; Strange, Charlie ; Teirstein, Alvin S. ; DePalo, Louis ; Brown, Sheldon ; Lesser, Marvin ; Padilla, Maria L. ; Marshall, Marilyn ; Newman, Lee S. ; Rose, Cecile ; Barnard, Juli ; Baughman, Robert P. ; Lower, Elysc E. ; Winget, Donna B. ; McLennan, Geoffrey ; Hunninghake, Gary ; Dayton, Chuck ; Powers, Linda ; Rossman, Milton D. ; Bresnitz, Eddy A. ; Daniele, Ronald ; Regovich, Jackie ; Sexauer, William ; Musson, Robert ; Deshler, Joanne ; Sorlie, Paul ; Wu, Margaret ; Cherniak, Reuben ; Newman, Lee ; Knatterud, Genell L. ; Terrin, Michael L. ; Thompson, Bruce W. ; Brown, Kathleen ; Frederick, Margaret ; LoPresti, Frances ; Wilkins, Patricia ; Canner, Martha ; Dotson, Judy ; Lindenfelser, Steve ; Cosentino, Mark ; Maliarik, Mary ; Baughman, Robert ; Rossman, Milton ; Monos, Dimitri ; Lee, Chung Wha ; Moller, David ; Pandey, Janardan ; Almenoff, Peter ; Brett, Ian ; Brown, Sheldon ; Lesser, Marvin ; Newman, Lee ; Kotzin, Brian ; McLennan, Geoffrey ; Hunninghake, Gary ; Finn, Patricia ; Jaffe, Richard D. ; Cherniack, Reuben ; Baughman, Robert P. ; Deshler, Joanne ; Iannuzzi, Michael C. ; Judson, Marc A. ; Knatterud, Genell L. ; McLennan, Geoffrey ; Moller, David R. ; Musson, Robert A. ; Newman, Lee S. ; Rossman, Milton D. ; Teirstein, Alvin S. ; Terrin, Michael L. ; Martin, William ; Ashikaga, Takamaru ; Coultas, David B. ; Davis, Gerald S. ; Gifford, Fred. / Robust trend tests for genetic association using matched case-control design. In: Statistics in Medicine. 2006 ; Vol. 25, No. 18. pp. 3160-3173.
@article{9f7b3a8f488f42faa4a34eead6eed2a7,
title = "Robust trend tests for genetic association using matched case-control design",
abstract = "Trend tests for genetic association using a matched case-control design are studied, which allows for a variable number of controls per case. However, the tests depend on the scores based on the underlying genetic model, thus it may result in substantial loss of power when the model is misspecified. Since the mode of inheritance may be unknown for complex diseases, robust trend tests in matched case-control studies are developed. Simulation is conducted to compare the trend tests and the robust trend tests under various genetic models. The results are applied to detect candidate-gene association using an example from a case-control aetiologic study of sarcoidosis.",
keywords = "Case-control study, MAX, MERT, Score test, Variable matching",
author = "Gang Zheng and Xin Tian and Weinberger, {Steven E.} and Patricia Finn and Erik Garpestad and Allison Moran and Henry Yeager and Rabin, {David L.} and Susan Stein and Iannuzzi, {Michael C.} and Rybicki, {Benjamin A.} and Marcie Major and Mary Maliarik and John Popovich and David Moller and Johns, {Carol J.} and Rand, {Cynthia S} and Joanne Steimel and Judson, {Marc A.} and Alessandro, {Susan D.} and Nancy Heister and Theresa Johnson and Lackland, {Daniel T.} and Janardan Pandey and Steven Sahn and Charlie Strange and Teirstein, {Alvin S.} and Louis DePalo and Sheldon Brown and Marvin Lesser and Padilla, {Maria L.} and Marilyn Marshall and Newman, {Lee S.} and Cecile Rose and Juli Barnard and Baughman, {Robert P.} and Lower, {Elysc E.} and Winget, {Donna B.} and Geoffrey McLennan and Gary Hunninghake and Chuck Dayton and Linda Powers and Rossman, {Milton D.} and Bresnitz, {Eddy A.} and Ronald Daniele and Jackie Regovich and William Sexauer and Robert Musson and Joanne Deshler and Paul Sorlie and Margaret Wu and Reuben Cherniak and Lee Newman and Knatterud, {Genell L.} and Terrin, {Michael L.} and Thompson, {Bruce W.} and Kathleen Brown and Margaret Frederick and Frances LoPresti and Patricia Wilkins and Martha Canner and Judy Dotson and Steve Lindenfelser and Mark Cosentino and Mary Maliarik and Robert Baughman and Milton Rossman and Dimitri Monos and Lee, {Chung Wha} and David Moller and Janardan Pandey and Peter Almenoff and Ian Brett and Sheldon Brown and Marvin Lesser and Lee Newman and Brian Kotzin and Geoffrey McLennan and Gary Hunninghake and Patricia Finn and Jaffe, {Richard D.} and Reuben Cherniack and Baughman, {Robert P.} and Joanne Deshler and Iannuzzi, {Michael C.} and Judson, {Marc A.} and Knatterud, {Genell L.} and Geoffrey McLennan and Moller, {David R.} and Musson, {Robert A.} and Newman, {Lee S.} and Rossman, {Milton D.} and Teirstein, {Alvin S.} and Terrin, {Michael L.} and William Martin and Takamaru Ashikaga and Coultas, {David B.} and Davis, {Gerald S.} and Fred Gifford",
year = "2006",
month = "9",
day = "30",
doi = "10.1002/sim.2278",
language = "English (US)",
volume = "25",
pages = "3160--3173",
journal = "Statistics in Medicine",
issn = "0277-6715",
publisher = "John Wiley and Sons Ltd",
number = "18",

}

TY - JOUR

T1 - Robust trend tests for genetic association using matched case-control design

AU - Zheng, Gang

AU - Tian, Xin

AU - Weinberger, Steven E.

AU - Finn, Patricia

AU - Garpestad, Erik

AU - Moran, Allison

AU - Yeager, Henry

AU - Rabin, David L.

AU - Stein, Susan

AU - Iannuzzi, Michael C.

AU - Rybicki, Benjamin A.

AU - Major, Marcie

AU - Maliarik, Mary

AU - Popovich, John

AU - Moller, David

AU - Johns, Carol J.

AU - Rand, Cynthia S

AU - Steimel, Joanne

AU - Judson, Marc A.

AU - Alessandro, Susan D.

AU - Heister, Nancy

AU - Johnson, Theresa

AU - Lackland, Daniel T.

AU - Pandey, Janardan

AU - Sahn, Steven

AU - Strange, Charlie

AU - Teirstein, Alvin S.

AU - DePalo, Louis

AU - Brown, Sheldon

AU - Lesser, Marvin

AU - Padilla, Maria L.

AU - Marshall, Marilyn

AU - Newman, Lee S.

AU - Rose, Cecile

AU - Barnard, Juli

AU - Baughman, Robert P.

AU - Lower, Elysc E.

AU - Winget, Donna B.

AU - McLennan, Geoffrey

AU - Hunninghake, Gary

AU - Dayton, Chuck

AU - Powers, Linda

AU - Rossman, Milton D.

AU - Bresnitz, Eddy A.

AU - Daniele, Ronald

AU - Regovich, Jackie

AU - Sexauer, William

AU - Musson, Robert

AU - Deshler, Joanne

AU - Sorlie, Paul

AU - Wu, Margaret

AU - Cherniak, Reuben

AU - Newman, Lee

AU - Knatterud, Genell L.

AU - Terrin, Michael L.

AU - Thompson, Bruce W.

AU - Brown, Kathleen

AU - Frederick, Margaret

AU - LoPresti, Frances

AU - Wilkins, Patricia

AU - Canner, Martha

AU - Dotson, Judy

AU - Lindenfelser, Steve

AU - Cosentino, Mark

AU - Maliarik, Mary

AU - Baughman, Robert

AU - Rossman, Milton

AU - Monos, Dimitri

AU - Lee, Chung Wha

AU - Moller, David

AU - Pandey, Janardan

AU - Almenoff, Peter

AU - Brett, Ian

AU - Brown, Sheldon

AU - Lesser, Marvin

AU - Newman, Lee

AU - Kotzin, Brian

AU - McLennan, Geoffrey

AU - Hunninghake, Gary

AU - Finn, Patricia

AU - Jaffe, Richard D.

AU - Cherniack, Reuben

AU - Baughman, Robert P.

AU - Deshler, Joanne

AU - Iannuzzi, Michael C.

AU - Judson, Marc A.

AU - Knatterud, Genell L.

AU - McLennan, Geoffrey

AU - Moller, David R.

AU - Musson, Robert A.

AU - Newman, Lee S.

AU - Rossman, Milton D.

AU - Teirstein, Alvin S.

AU - Terrin, Michael L.

AU - Martin, William

AU - Ashikaga, Takamaru

AU - Coultas, David B.

AU - Davis, Gerald S.

AU - Gifford, Fred

PY - 2006/9/30

Y1 - 2006/9/30

N2 - Trend tests for genetic association using a matched case-control design are studied, which allows for a variable number of controls per case. However, the tests depend on the scores based on the underlying genetic model, thus it may result in substantial loss of power when the model is misspecified. Since the mode of inheritance may be unknown for complex diseases, robust trend tests in matched case-control studies are developed. Simulation is conducted to compare the trend tests and the robust trend tests under various genetic models. The results are applied to detect candidate-gene association using an example from a case-control aetiologic study of sarcoidosis.

AB - Trend tests for genetic association using a matched case-control design are studied, which allows for a variable number of controls per case. However, the tests depend on the scores based on the underlying genetic model, thus it may result in substantial loss of power when the model is misspecified. Since the mode of inheritance may be unknown for complex diseases, robust trend tests in matched case-control studies are developed. Simulation is conducted to compare the trend tests and the robust trend tests under various genetic models. The results are applied to detect candidate-gene association using an example from a case-control aetiologic study of sarcoidosis.

KW - Case-control study

KW - MAX

KW - MERT

KW - Score test

KW - Variable matching

UR - http://www.scopus.com/inward/record.url?scp=33748600432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748600432&partnerID=8YFLogxK

U2 - 10.1002/sim.2278

DO - 10.1002/sim.2278

M3 - Article

VL - 25

SP - 3160

EP - 3173

JO - Statistics in Medicine

JF - Statistics in Medicine

SN - 0277-6715

IS - 18

ER -