RNA in unexpected places: Long non-coding RNA functions in diverse cellular contexts

Sarah Geisler, Jeff Coller

Research output: Contribution to journalReview articlepeer-review

Abstract

The increased application of transcriptome-wide profiling approaches has led to an explosion in the number of documented long non-coding RNAs (lncRNAs). While these new and enigmatic players in the complex transcriptional milieu are encoded by a significant proportion of the genome, their functions are mostly unknown. Early discoveries support a paradigm in which lncRNAs regulate transcription via chromatin modulation, but new functions are steadily emerging. Given the biochemical versatility of RNA, lncRNAs may be used for various tasks, including post-transcriptional regulation, organization of protein complexes, cell-cell signalling and allosteric regulation of proteins.

Original languageEnglish (US)
Pages (from-to)699-712
Number of pages14
JournalNature Reviews Molecular Cell Biology
Volume14
Issue number11
DOIs
StatePublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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