TY - JOUR
T1 - RNA granules in germ cells
AU - Voronina, Ekaterina
AU - Seydoux, Geraldine
AU - Sassone-Corsi, Paolo
AU - Nagamori, Ippei
PY - 2011/12
Y1 - 2011/12
N2 - "Germ granules" are cytoplasmic, nonmembrane-bound organelles unique to germline. Germ granules share components with the P bodies and stress granules of somatic cells, but also contain proteins and RNAs uniquely required for germ cell development. In this review, we focus on recent advances in our understanding of germ granule assembly, dynamics, and function. One hypothesis is that germ granules operate as hubs for the posttranscriptional control of gene expression, a function at the core of the germ cell differentiation program.
AB - "Germ granules" are cytoplasmic, nonmembrane-bound organelles unique to germline. Germ granules share components with the P bodies and stress granules of somatic cells, but also contain proteins and RNAs uniquely required for germ cell development. In this review, we focus on recent advances in our understanding of germ granule assembly, dynamics, and function. One hypothesis is that germ granules operate as hubs for the posttranscriptional control of gene expression, a function at the core of the germ cell differentiation program.
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U2 - 10.1101/cshperspect.a002774
DO - 10.1101/cshperspect.a002774
M3 - Review article
C2 - 21768607
AN - SCOPUS:84863945534
SN - 1943-0264
VL - 3
JO - Cold Spring Harbor Perspectives in Biology
JF - Cold Spring Harbor Perspectives in Biology
IS - 12
ER -