Ritonavir Use in Human Immunodeficiency Virus-Positive Surgical Patients Is Not Associated with an Increase in Postoperative Critical Respiratory Events

Dermot P. Maher; Jacqueline Lee; Pauline Woo; Xiao Zhang; Paul F. White; Roya Yumul; Antonio Hernandez Conte

doi:10.3109/15360288.2015.1135846

Ritonavir Use in Human Immunodeficiency Virus-Positive Surgical Patients Is Not Associated with an Increase in Postoperative Critical Respiratory Events

Dermot P. Maher, Jacqueline Lee, Pauline Woo, Xiao Zhang, Paul F. White, Roya Yumul, Antonio Hernandez Conte

Research output: Contribution to journal › Article › peer-review

Abstract

This study evaluated whether highly active antiretroviral therapy for human immunodeficiency virus (HIV) including ritonavir is independently associated with increased critical respiratory events after general anesthesia with opioid analgesia. The impact of ritonavir on hepatic microsomal enzymes was considered due to the effect of these enzymes on opioid metabolism. Medical records of over 1900 patients were reviewed, and those of 941 patients met inclusion criteria and were analyzed. Chronic treatment with ritonavir was not associated with critical respiratory events in HIV-positive patients.

Original language	English (US)
Pages (from-to)	25-30
Number of pages	6
Journal	Journal of Pain and Palliative Care Pharmacotherapy
Volume	30
Issue number	1
DOIs	https://doi.org/10.3109/15360288.2015.1135846
State	Published - Jan 2 2016
Externally published	Yes

Keywords

Critical events
HIV
drug interaction
opioid
respiratory
ritonavir

ASJC Scopus subject areas

Anesthesiology and Pain Medicine
Pharmacology (medical)

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10.3109/15360288.2015.1135846

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Ritonavir Use in Human Immunodeficiency Virus-Positive Surgical Patients Is Not Associated with an Increase in Postoperative Critical Respiratory Events. / Maher, Dermot P.; Lee, Jacqueline; Woo, Pauline et al.
In: Journal of Pain and Palliative Care Pharmacotherapy, Vol. 30, No. 1, 02.01.2016, p. 25-30.

Research output: Contribution to journal › Article › peer-review

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AU - White, Paul F.

AU - Yumul, Roya

AU - Hernandez Conte, Antonio

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Ritonavir Use in Human Immunodeficiency Virus-Positive Surgical Patients Is Not Associated with an Increase in Postoperative Critical Respiratory Events

Abstract

Keywords

ASJC Scopus subject areas

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