TY - JOUR
T1 - Risks associated with fertility preservation for women with sickle cell anemia
AU - Pecker, Lydia H.
AU - Maher, Jacqueline Y.
AU - Law, Jennie Y.
AU - Beach, Mary Catherine
AU - Lanzkron, Sophie
AU - Christianson, Mindy S.
N1 - Publisher Copyright:
© 2018 American Society for Reproductive Medicine
PY - 2018/9
Y1 - 2018/9
N2 - Objective: To highlight the risk of complications among women with sickle cell anemia (SCA) receiving fertility preservation treatment (FPT) before hematopoietic stem cell transplant (HSCT). Design: Single-center case series. Setting: Academic fertility center. Patient(s): Women aged 15–32 years with SCA undergoing FPT before HSCT. Intervention(s): Retrospective, systematic review. Main Outcome Measure(s): FPT modality, SCA complications during FPT. Result(s): Over an 8-year period (2009–2017), seven women with SCA ages 15–32 years (mean 28.5 years) underwent FPT with embryo cryopreservation (n = 1), oocyte cryopreservation (n = 4), and ovarian tissue cryopreservation (n = 2). The five women subjects who underwent oocyte or embryo cryopreservation were treated with an antagonist controlled ovarian hyperstimulation protocol and individualized gonadotropin dosing. The trigger medications included leuprolide acetate (n = 2), and human chorionic gonadotropin (n = 3). Most patients (n = 5) received a disease-modifying therapy for SCA (hydroxyurea or chronic transfusions) before FPT. Three patients experienced periprocedural SCA complications that included life-threatening respiratory failure, painful crisis requiring interruption of a stimulation cycle, and severe postharvest painful crisis. Conclusion(s): Women with SCA may choose to undergo diverse FPT strategies before HSCT and are at risk for serious SCA-related complications. Evidence-based strategies to mitigate SCA-related morbidity and to optimize fertility preservation outcomes are needed.
AB - Objective: To highlight the risk of complications among women with sickle cell anemia (SCA) receiving fertility preservation treatment (FPT) before hematopoietic stem cell transplant (HSCT). Design: Single-center case series. Setting: Academic fertility center. Patient(s): Women aged 15–32 years with SCA undergoing FPT before HSCT. Intervention(s): Retrospective, systematic review. Main Outcome Measure(s): FPT modality, SCA complications during FPT. Result(s): Over an 8-year period (2009–2017), seven women with SCA ages 15–32 years (mean 28.5 years) underwent FPT with embryo cryopreservation (n = 1), oocyte cryopreservation (n = 4), and ovarian tissue cryopreservation (n = 2). The five women subjects who underwent oocyte or embryo cryopreservation were treated with an antagonist controlled ovarian hyperstimulation protocol and individualized gonadotropin dosing. The trigger medications included leuprolide acetate (n = 2), and human chorionic gonadotropin (n = 3). Most patients (n = 5) received a disease-modifying therapy for SCA (hydroxyurea or chronic transfusions) before FPT. Three patients experienced periprocedural SCA complications that included life-threatening respiratory failure, painful crisis requiring interruption of a stimulation cycle, and severe postharvest painful crisis. Conclusion(s): Women with SCA may choose to undergo diverse FPT strategies before HSCT and are at risk for serious SCA-related complications. Evidence-based strategies to mitigate SCA-related morbidity and to optimize fertility preservation outcomes are needed.
KW - Bone marrow transplant
KW - female infertility
KW - fertility preservation treatment
KW - sickle cell anemia
KW - sickle cell disease
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U2 - 10.1016/j.fertnstert.2018.05.016
DO - 10.1016/j.fertnstert.2018.05.016
M3 - Article
C2 - 30196969
AN - SCOPUS:85052920429
SN - 0015-0282
VL - 110
SP - 720
EP - 731
JO - Fertility and sterility
JF - Fertility and sterility
IS - 4
ER -