Risk stratification in patients with remote prior myocardial infarction using rest-stress myocardial perfusion SPECT

Prognostic value and impact on referral to early catheterization

Michael J. Zellweger, Eric A. Dubois, Shenghan Lai, Leslee J. Shaw, Aman M. Amanullah, Howard C. Lewin, John D. Friedman, Xingping Kang, Guido Germano, Daniel S. Berman

Research output: Contribution to journalArticle

Abstract

Background. Little is known about the prognostic value of myocardial perfusion single photon emission computed tomography (SPECT) in patients with remote prior myocardial infarction (MI). Methods and Results. We identified 1413 consecutive patients with remote prior MI who underwent rest-stress myocardial perfusion SPECT. Semiquantitative visual analysis of 20 SPECT segments was used to define the summed stress, rest, and difference scores. The number of non-reversible segments was used as an index of infarct size. During follow-up (≥1 year), 118 hard events occurred: 64 cardiac deaths (CDs) and 54 recurrent MIs. Annual CD and hard event rates increased significantly as a function of SPECT abnormality. For summed stress scores less than 4, 4 to 8, 9 to 13, and more than 13, the annual CD rates were 0.4%, 0.9%, 1.7%, and 3.5%, respectively (P = .002). Patients with small MI (

Original languageEnglish (US)
Pages (from-to)23-32
Number of pages10
JournalJournal of Nuclear Cardiology
Volume9
Issue number1
DOIs
StatePublished - 2002

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Single-Photon Emission-Computed Tomography
Catheterization
Referral and Consultation
Perfusion
Myocardial Infarction
Mortality

Keywords

  • Myocardial perfusion single photon emission computed tomography
  • Remote prior myocardial infarction
  • Risk stratification and prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Risk stratification in patients with remote prior myocardial infarction using rest-stress myocardial perfusion SPECT : Prognostic value and impact on referral to early catheterization. / Zellweger, Michael J.; Dubois, Eric A.; Lai, Shenghan; Shaw, Leslee J.; Amanullah, Aman M.; Lewin, Howard C.; Friedman, John D.; Kang, Xingping; Germano, Guido; Berman, Daniel S.

In: Journal of Nuclear Cardiology, Vol. 9, No. 1, 2002, p. 23-32.

Research output: Contribution to journalArticle

Zellweger, Michael J. ; Dubois, Eric A. ; Lai, Shenghan ; Shaw, Leslee J. ; Amanullah, Aman M. ; Lewin, Howard C. ; Friedman, John D. ; Kang, Xingping ; Germano, Guido ; Berman, Daniel S. / Risk stratification in patients with remote prior myocardial infarction using rest-stress myocardial perfusion SPECT : Prognostic value and impact on referral to early catheterization. In: Journal of Nuclear Cardiology. 2002 ; Vol. 9, No. 1. pp. 23-32.
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AU - Lai, Shenghan

AU - Shaw, Leslee J.

AU - Amanullah, Aman M.

AU - Lewin, Howard C.

AU - Friedman, John D.

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AU - Germano, Guido

AU - Berman, Daniel S.

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