Risk Stratification for Acute Kidney Injury: Are Biomarkers Enough?

Blaithin A. McMahon, Jay L. Koyner

Research output: Contribution to journalReview article

Abstract

Acute kidney injury (AKI) is a common and serious complication that is associated with several adverse outcomes in hospitalized patients. AKI significantly increases the risk of mortality, need for renal replacement therapy, and intensive care admission, and it also has serious economic ramifications. Effective risk stratification to identify patients at risk for severe AKI is essential for targeting our health care and research resources to tackle this important public health issue. The overwhelming majority of research in earlier diagnosis and risk stratification of AKI over the past 10 years has focused on novel biomarker development. The purpose of this review is to provide an update on other novel risk stratification tools than can be used in the prognostication of AKI. We discuss the utility of the furosemide stress test in predicting the severity of AKI and the renal angina index in predicting the occurrence of AKI. We also discuss NephroCheck, a prognostic test that measures tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for the early detection of severe AKI.

Original languageEnglish (US)
Pages (from-to)167-178
Number of pages12
JournalAdvances in Chronic Kidney Disease
Volume23
Issue number3
DOIs
StatePublished - May 1 2016

Fingerprint

Acute Kidney Injury
Biomarkers
Tissue Inhibitor of Metalloproteinase-2
Renal Replacement Therapy
Health Services Research
Furosemide
Critical Care
Exercise Test
Early Diagnosis
Public Health
Economics
Kidney
Mortality
Research

Keywords

  • Acute kidney injury
  • Biomarkers
  • Renal replacement therapy
  • Risk assessment

ASJC Scopus subject areas

  • Nephrology

Cite this

Risk Stratification for Acute Kidney Injury : Are Biomarkers Enough? / McMahon, Blaithin A.; Koyner, Jay L.

In: Advances in Chronic Kidney Disease, Vol. 23, No. 3, 01.05.2016, p. 167-178.

Research output: Contribution to journalReview article

McMahon, Blaithin A. ; Koyner, Jay L. / Risk Stratification for Acute Kidney Injury : Are Biomarkers Enough?. In: Advances in Chronic Kidney Disease. 2016 ; Vol. 23, No. 3. pp. 167-178.
@article{1453d7974bc74baa98d2e19289b509a6,
title = "Risk Stratification for Acute Kidney Injury: Are Biomarkers Enough?",
abstract = "Acute kidney injury (AKI) is a common and serious complication that is associated with several adverse outcomes in hospitalized patients. AKI significantly increases the risk of mortality, need for renal replacement therapy, and intensive care admission, and it also has serious economic ramifications. Effective risk stratification to identify patients at risk for severe AKI is essential for targeting our health care and research resources to tackle this important public health issue. The overwhelming majority of research in earlier diagnosis and risk stratification of AKI over the past 10 years has focused on novel biomarker development. The purpose of this review is to provide an update on other novel risk stratification tools than can be used in the prognostication of AKI. We discuss the utility of the furosemide stress test in predicting the severity of AKI and the renal angina index in predicting the occurrence of AKI. We also discuss NephroCheck, a prognostic test that measures tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for the early detection of severe AKI.",
keywords = "Acute kidney injury, Biomarkers, Renal replacement therapy, Risk assessment",
author = "McMahon, {Blaithin A.} and Koyner, {Jay L.}",
year = "2016",
month = "5",
day = "1",
doi = "10.1053/j.ackd.2016.03.001",
language = "English (US)",
volume = "23",
pages = "167--178",
journal = "Advances in Chronic Kidney Disease",
issn = "1548-5595",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Risk Stratification for Acute Kidney Injury

T2 - Are Biomarkers Enough?

AU - McMahon, Blaithin A.

AU - Koyner, Jay L.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Acute kidney injury (AKI) is a common and serious complication that is associated with several adverse outcomes in hospitalized patients. AKI significantly increases the risk of mortality, need for renal replacement therapy, and intensive care admission, and it also has serious economic ramifications. Effective risk stratification to identify patients at risk for severe AKI is essential for targeting our health care and research resources to tackle this important public health issue. The overwhelming majority of research in earlier diagnosis and risk stratification of AKI over the past 10 years has focused on novel biomarker development. The purpose of this review is to provide an update on other novel risk stratification tools than can be used in the prognostication of AKI. We discuss the utility of the furosemide stress test in predicting the severity of AKI and the renal angina index in predicting the occurrence of AKI. We also discuss NephroCheck, a prognostic test that measures tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for the early detection of severe AKI.

AB - Acute kidney injury (AKI) is a common and serious complication that is associated with several adverse outcomes in hospitalized patients. AKI significantly increases the risk of mortality, need for renal replacement therapy, and intensive care admission, and it also has serious economic ramifications. Effective risk stratification to identify patients at risk for severe AKI is essential for targeting our health care and research resources to tackle this important public health issue. The overwhelming majority of research in earlier diagnosis and risk stratification of AKI over the past 10 years has focused on novel biomarker development. The purpose of this review is to provide an update on other novel risk stratification tools than can be used in the prognostication of AKI. We discuss the utility of the furosemide stress test in predicting the severity of AKI and the renal angina index in predicting the occurrence of AKI. We also discuss NephroCheck, a prognostic test that measures tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for the early detection of severe AKI.

KW - Acute kidney injury

KW - Biomarkers

KW - Renal replacement therapy

KW - Risk assessment

UR - http://www.scopus.com/inward/record.url?scp=84963959758&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963959758&partnerID=8YFLogxK

U2 - 10.1053/j.ackd.2016.03.001

DO - 10.1053/j.ackd.2016.03.001

M3 - Review article

C2 - 27113693

AN - SCOPUS:84963959758

VL - 23

SP - 167

EP - 178

JO - Advances in Chronic Kidney Disease

JF - Advances in Chronic Kidney Disease

SN - 1548-5595

IS - 3

ER -