To the Editor: Abbott et al. (Sept. 18 issue)1 note that treatment of hypertension has contributed to the decline in the incidence of stroke, but they provide no information on antihypertensive treatment in their study subjects. It has also been suggested that some types of treatment reduce the risk of stroke more than is expected from the blood-pressure reduction alone.2 Furthermore, two studies have shown a smoking–treatment interaction in the prevention of cerebrovascular2 and cardiac3 events. Differences in the frequency and type of antihypertensive therapy over the 12-year follow-up period may have accounted for some of the differences in the.
ASJC Scopus subject areas