Risk of second tumor in intracranial germinoma patients treated with radiation therapy: The Johns Hopkins experience

Salma K. Jabbour, Zhe Zhang, Dagmar Arnold, Moody D. Wharam

Research output: Contribution to journalArticle

Abstract

Background: We reviewed the risk of second tumor (ST), both malignant and benign, in germinoma survivors followed at the Johns Hopkins Hospital (JHH). Methods: Between 1977 and 2002, 27 patients with intracranial germinoma were treated with radiation therapy (RT). In the presence of competing events, a cumulative incidence function of ST was estimated using the minimal time interval from the date of diagnosis to the date of ST, date of death, or date of last follow-up. Results: Five patients (18%) developed a ST of which 4 (15%) were malignant. One developed a benign falcine meningioma. The cumulative incidence of ST was 9% at 11 years (95% CI, 0-22%). Conclusions: The relative contributions of RT and patient susceptibility to a ST cannot be determined but suggests the need for long-term surveillance, including testicular self-exams in male germinoma survivors. Current trials of chemotherapy and reduced RT dose and volume offer the prospect of a lower risk of treatment-induced ST.

Original languageEnglish (US)
Pages (from-to)227-232
Number of pages6
JournalJournal of Neuro-Oncology
Volume91
Issue number2
DOIs
StatePublished - 2009

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Germinoma
Radiotherapy
Neoplasms
Survivors
Incidence
Meningioma
Drug Therapy

Keywords

  • Chemotherapy
  • Germinoma
  • Radiotherapy
  • Second malignant neoplasm
  • Second tumor

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology

Cite this

Risk of second tumor in intracranial germinoma patients treated with radiation therapy : The Johns Hopkins experience. / Jabbour, Salma K.; Zhang, Zhe; Arnold, Dagmar; Wharam, Moody D.

In: Journal of Neuro-Oncology, Vol. 91, No. 2, 2009, p. 227-232.

Research output: Contribution to journalArticle

Jabbour, Salma K. ; Zhang, Zhe ; Arnold, Dagmar ; Wharam, Moody D. / Risk of second tumor in intracranial germinoma patients treated with radiation therapy : The Johns Hopkins experience. In: Journal of Neuro-Oncology. 2009 ; Vol. 91, No. 2. pp. 227-232.
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