Risk of second tumor in intracranial germinoma patients treated with radiation therapy: The Johns Hopkins experience

Salma K. Jabbour, Zhe Zhang, Dagmar Arnold, Moody D. Wharam

Research output: Contribution to journalArticle

Abstract

Background: We reviewed the risk of second tumor (ST), both malignant and benign, in germinoma survivors followed at the Johns Hopkins Hospital (JHH). Methods: Between 1977 and 2002, 27 patients with intracranial germinoma were treated with radiation therapy (RT). In the presence of competing events, a cumulative incidence function of ST was estimated using the minimal time interval from the date of diagnosis to the date of ST, date of death, or date of last follow-up. Results: Five patients (18%) developed a ST of which 4 (15%) were malignant. One developed a benign falcine meningioma. The cumulative incidence of ST was 9% at 11 years (95% CI, 0-22%). Conclusions: The relative contributions of RT and patient susceptibility to a ST cannot be determined but suggests the need for long-term surveillance, including testicular self-exams in male germinoma survivors. Current trials of chemotherapy and reduced RT dose and volume offer the prospect of a lower risk of treatment-induced ST.

Original languageEnglish (US)
Pages (from-to)227-232
Number of pages6
JournalJournal of neuro-oncology
Volume91
Issue number2
DOIs
StatePublished - Jan 1 2009

Keywords

  • Chemotherapy
  • Germinoma
  • Radiotherapy
  • Second malignant neoplasm
  • Second tumor

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Fingerprint Dive into the research topics of 'Risk of second tumor in intracranial germinoma patients treated with radiation therapy: The Johns Hopkins experience'. Together they form a unique fingerprint.

  • Cite this