TY - JOUR
T1 - Risk of second primary malignancy after nasopharyngeal carcinoma in the United States
T2 - A population-based study
AU - Chan, Jason Y.K.
AU - Gooi, Zhen
AU - Mydlarz, Wojciech K.
AU - Agrawal, Nishant
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Background The purpose of this study was to evaluate the incidence of second primary malignancies in patients diagnosed with an index nasopharyngeal carcinoma (NPC) in the United States. Methods The cohort was assembled from the Surveillance, Epidemiology, and End Results (SEER) database with a primary NPC between 1973 and 2005. Results There was a 47% increased risk of second primary malignancy. The sites with increased risk include the oral cavity and pharynx (standardized incidence ratio [SIR] = 7.11; 95% confidence interval [CI] = 5.21-9.49), esophagus (SIR = 3.50; 95% CI = 1.68-6.44), nose, nasal cavity, and middle ear (SIR = 15.54; 95% CI = 5.70-33.83), and lung and bronchus (SIR = 2.39; 95% CI = 1.91-2.96). Conclusion Patients with NPC are likely at a significant risk for second primary malignancies, most notably in the oral cavity and pharynx, which is most likely related to genetic susceptibility, increased surveillance, and treatment effects.
AB - Background The purpose of this study was to evaluate the incidence of second primary malignancies in patients diagnosed with an index nasopharyngeal carcinoma (NPC) in the United States. Methods The cohort was assembled from the Surveillance, Epidemiology, and End Results (SEER) database with a primary NPC between 1973 and 2005. Results There was a 47% increased risk of second primary malignancy. The sites with increased risk include the oral cavity and pharynx (standardized incidence ratio [SIR] = 7.11; 95% confidence interval [CI] = 5.21-9.49), esophagus (SIR = 3.50; 95% CI = 1.68-6.44), nose, nasal cavity, and middle ear (SIR = 15.54; 95% CI = 5.70-33.83), and lung and bronchus (SIR = 2.39; 95% CI = 1.91-2.96). Conclusion Patients with NPC are likely at a significant risk for second primary malignancies, most notably in the oral cavity and pharynx, which is most likely related to genetic susceptibility, increased surveillance, and treatment effects.
KW - disease surveillance
KW - nasopharyngeal carcinoma
KW - oral cavity cancer
KW - second primary cancer
KW - survival
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U2 - 10.1002/hed.24173
DO - 10.1002/hed.24173
M3 - Article
C2 - 26314805
AN - SCOPUS:84940507289
SN - 0148-6403
VL - 38
SP - E1130-E1136
JO - Head and Neck Surgery
JF - Head and Neck Surgery
ER -