Risk of second primary malignancy after nasopharyngeal carcinoma in the United States: A population-based study

Jason Y.K. Chan, Zhen Gooi, Wojciech K. Mydlarz, Nishant Agrawal

Research output: Contribution to journalArticlepeer-review

Abstract

Background The purpose of this study was to evaluate the incidence of second primary malignancies in patients diagnosed with an index nasopharyngeal carcinoma (NPC) in the United States. Methods The cohort was assembled from the Surveillance, Epidemiology, and End Results (SEER) database with a primary NPC between 1973 and 2005. Results There was a 47% increased risk of second primary malignancy. The sites with increased risk include the oral cavity and pharynx (standardized incidence ratio [SIR] = 7.11; 95% confidence interval [CI] = 5.21-9.49), esophagus (SIR = 3.50; 95% CI = 1.68-6.44), nose, nasal cavity, and middle ear (SIR = 15.54; 95% CI = 5.70-33.83), and lung and bronchus (SIR = 2.39; 95% CI = 1.91-2.96). Conclusion Patients with NPC are likely at a significant risk for second primary malignancies, most notably in the oral cavity and pharynx, which is most likely related to genetic susceptibility, increased surveillance, and treatment effects.

Original languageEnglish (US)
Pages (from-to)E1130-E1136
JournalHead and Neck
Volume38
DOIs
StatePublished - Apr 1 2016

Keywords

  • disease surveillance
  • nasopharyngeal carcinoma
  • oral cavity cancer
  • second primary cancer
  • survival

ASJC Scopus subject areas

  • Otorhinolaryngology

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