Risk of second malignant neoplasms among lymphoma patients with a family history of cancer

Ola Landgren, Ruth M. Pfeiffer, Laveta Stewart, Gloria Gridley, Lene Mellemkjaer, Kari Hemminki, Lynn R. Goldin, Lois B. Travis

Research output: Contribution to journalArticle

Abstract

Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL) (n = 25,941), or chronic lymphocytic leukemia (CLL) (n = 7,764), using a large population-based database. Family history of cancer was based on a diagnosis of any cancer in 110,862 first-degree relatives. We found increased relative risk (RR) (1.81, 95% confidence interval (CI): 1.04-3.16) of breast cancer among HL patient with positive (vs. negative) family history of cancer. Among CLL patients with positive (vs. negative) family history of cancer, we observed elevated risks of bladder (RR = 3.53, 95% CI: 1.31-9.55) and prostate cancer (RR = 2.15, 95% CI: 1.17-3.94). For NHL patients with positive (vs. negative) family history of cancer, we observed non-significantly increased risk of non-melanoma skin cancer (RR = 1.94, 95% CI: 0.86-4.38) and lung cancer (RR = 1.99, 95% CI: 0.73-5.39). Our observations suggest that genetic factors, as measured by positive family history of cancer, may be influential risk-factors for selected second tumors following lymphoproliferative disorders.

Original languageEnglish (US)
Pages (from-to)1099-1102
Number of pages4
JournalInternational Journal of Cancer
Volume120
Issue number5
DOIs
StatePublished - Mar 1 2007
Externally publishedYes

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Second Primary Neoplasms
Lymphoma
Confidence Intervals
Neoplasms
B-Cell Chronic Lymphocytic Leukemia
Hodgkin Disease
Non-Hodgkin's Lymphoma
Lymphoproliferative Disorders
Skin Neoplasms
Lung Neoplasms
Prostatic Neoplasms
Urinary Bladder
Radiotherapy
Databases
Breast Neoplasms
Drug Therapy

Keywords

  • Chronic lymphocytic leukemia
  • DNA repair mechanisms
  • Familial aggregation
  • Family history
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
  • Second neoplasm
  • Susceptibility

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Landgren, O., Pfeiffer, R. M., Stewart, L., Gridley, G., Mellemkjaer, L., Hemminki, K., ... Travis, L. B. (2007). Risk of second malignant neoplasms among lymphoma patients with a family history of cancer. International Journal of Cancer, 120(5), 1099-1102. https://doi.org/10.1002/ijc.22414

Risk of second malignant neoplasms among lymphoma patients with a family history of cancer. / Landgren, Ola; Pfeiffer, Ruth M.; Stewart, Laveta; Gridley, Gloria; Mellemkjaer, Lene; Hemminki, Kari; Goldin, Lynn R.; Travis, Lois B.

In: International Journal of Cancer, Vol. 120, No. 5, 01.03.2007, p. 1099-1102.

Research output: Contribution to journalArticle

Landgren, O, Pfeiffer, RM, Stewart, L, Gridley, G, Mellemkjaer, L, Hemminki, K, Goldin, LR & Travis, LB 2007, 'Risk of second malignant neoplasms among lymphoma patients with a family history of cancer', International Journal of Cancer, vol. 120, no. 5, pp. 1099-1102. https://doi.org/10.1002/ijc.22414
Landgren O, Pfeiffer RM, Stewart L, Gridley G, Mellemkjaer L, Hemminki K et al. Risk of second malignant neoplasms among lymphoma patients with a family history of cancer. International Journal of Cancer. 2007 Mar 1;120(5):1099-1102. https://doi.org/10.1002/ijc.22414
Landgren, Ola ; Pfeiffer, Ruth M. ; Stewart, Laveta ; Gridley, Gloria ; Mellemkjaer, Lene ; Hemminki, Kari ; Goldin, Lynn R. ; Travis, Lois B. / Risk of second malignant neoplasms among lymphoma patients with a family history of cancer. In: International Journal of Cancer. 2007 ; Vol. 120, No. 5. pp. 1099-1102.
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