Risk of retinal neovascularization in cases of uveitis

Apurva K. Patel, Craig W. Newcomb, Teresa L. Liesegang, Siddharth S. Pujari, Eric B. Suhler, Jennifer Thorne, C. Stephen Foster, Douglas Jabs, Grace A. Levy-Clarke, Robert B. Nussenblatt, James T. Rosenbaum, H. Nida Sen, Pichaporn Artornsombudh, Srishti Kothari, John H. Kempen

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Abstract

Purpose To evaluate the risk of and risk factors for retinal neovascularization (NV) in cases of uveitis. Design Retrospective cohort study. Participants Patients with uveitis at 4 US academic ocular inflammation subspecialty practices. Methods Data were ascertained by standardized chart review. Prevalence data analysis used logistic regression. Incidence data analysis used survival analysis with time-updated covariates where appropriate. Main Outcome Measures Prevalence and incidence of NV. Results Among uveitic eyes of 8931 patients presenting for initial evaluation, 106 of 13 810 eyes had NV (prevalence = 0.77%, 95% confidence interval [CI], 0.60-0.90). Eighty-eight more eyes developed NV over 26 465 eye-years (incidence, 0.33%/eye-year; 95% CI, 0.27-0.41). Factors associated with incident NV include age 35 years (adjusted hazard ratio [aHR], 2.4; 95% CI, 1.5-3.9), current cigarette smoking (aHR, 1.9; 95% CI, 1.1-3.4), and systemic lupus erythematosus (aHR, 3.5, 95% CI, 1.1-11). Recent diagnosis of uveitis was associated with an increased incidence of NV (compared with patients diagnosed >5 years ago, aHR, 2.4 [95% CI, 1.1-5.0] and aHR, 2.6 [95% CI, 1.2-6.0] for diagnosis within

Original languageEnglish (US)
Pages (from-to)646-654
Number of pages9
JournalOphthalmology
Volume123
Issue number3
DOIs
StatePublished - Mar 1 2016

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ASJC Scopus subject areas

  • Ophthalmology

Cite this

Patel, A. K., Newcomb, C. W., Liesegang, T. L., Pujari, S. S., Suhler, E. B., Thorne, J., Foster, C. S., Jabs, D., Levy-Clarke, G. A., Nussenblatt, R. B., Rosenbaum, J. T., Sen, H. N., Artornsombudh, P., Kothari, S., & Kempen, J. H. (2016). Risk of retinal neovascularization in cases of uveitis. Ophthalmology, 123(3), 646-654. https://doi.org/10.1016/j.ophtha.2015.10.056