Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1

Pauline Mendola, Kirsten B. Moysich, Jo L. Freudenheim, Peter G. Shields, Enrique F. Schisterman, Saxon Graham, John E. Vena, James R. Marshall, Christine B. Ambrosone

Research output: Contribution to journalArticle

Abstract

Maternal smoking increases the risk of spontaneous abortion. Polymorphic N-acetyltransferase (NAT2) and glutathione S-transferase (GSTM1) affect metabolism of some mutagens found in tobacco smoke. Genotypes and smoking were studied in women with at least two spontaneous abortions (N = 32) and those with at least two livebirths (N = 179). Smoking slightly increased risk (odds ratio = 1.3; 95% confidence interval = 0.6-2.9), but NAT2 and GSTM1 did not. NAT2 or GSTM1 polymorphisms did not appreciably modify smoking-related risk.

Original languageEnglish (US)
Pages (from-to)666-668
Number of pages3
JournalEpidemiology
Volume9
Issue number6
StatePublished - Nov 1998
Externally publishedYes

Keywords

  • Gene-environment interaction
  • Genetic polymorphism
  • Glutathione S-transferase M1
  • Molecular epidemiology
  • N-acetyltransferase 2
  • Spontaneous abortion

ASJC Scopus subject areas

  • Epidemiology

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  • Cite this

    Mendola, P., Moysich, K. B., Freudenheim, J. L., Shields, P. G., Schisterman, E. F., Graham, S., Vena, J. E., Marshall, J. R., & Ambrosone, C. B. (1998). Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1. Epidemiology, 9(6), 666-668.