Abstract
Maternal smoking increases the risk of spontaneous abortion. Polymorphic N-acetyltransferase (NAT2) and glutathione S-transferase (GSTM1) affect metabolism of some mutagens found in tobacco smoke. Genotypes and smoking were studied in women with at least two spontaneous abortions (N = 32) and those with at least two livebirths (N = 179). Smoking slightly increased risk (odds ratio = 1.3; 95% confidence interval = 0.6-2.9), but NAT2 and GSTM1 did not. NAT2 or GSTM1 polymorphisms did not appreciably modify smoking-related risk.
Original language | English (US) |
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Pages (from-to) | 666-668 |
Number of pages | 3 |
Journal | Epidemiology |
Volume | 9 |
Issue number | 6 |
DOIs | |
State | Published - Nov 1998 |
Externally published | Yes |
Keywords
- Gene-environment interaction
- Genetic polymorphism
- Glutathione S-transferase M1
- Molecular epidemiology
- N-acetyltransferase 2
- Spontaneous abortion
ASJC Scopus subject areas
- Epidemiology