Risk of radiation-related subsequent malignant tumors in survivors of Ewing’s sarcoma

Louise C. Strong, Jay Herson, Barbara M. Osborne, Wataru W. Sutow

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-four long-term survivors of Ewing’s sarcoma were Identified as being at risk for a second primary tumor. Among this group of patients followed from 3 to 22 years, 4 new bone tumors were observed, whereas 1.2×10-3 were expected. All new tumors arose in heavily irradiated areas. The risk associated with radiation after 3 years was 7.2 cases/million person-years per rad. The cumulative cancer risk over 10 years for Irradiated patients was 35% (SE, 15.1%). Intensive chemotherapy (cyclophosphamide and vincristine administered in five or more courses) seemed to exert an enhancing effect, increasing the rate of development of new tumors.

Original languageEnglish (US)
Pages (from-to)1401-1406
Number of pages6
JournalJournal of the National Cancer Institute
Volume62
Issue number6
DOIs
StatePublished - Jun 1979
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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