Risk of prostate cancer on first re-biopsy within 1 year following a diagnosis of high grade prostatic intraepithelial neoplasia is related to the number of cores sampled

Mehsati Herawi, Hillel Kahane, Christina Cavallo, Jonathan Ira Epstein

Research output: Contribution to journalArticle

Abstract

Purpose: We determined the influence of the extent of needle biopsy sampling on the detection rate of cancer on first biopsy within 1 year following a diagnosis of HGPIN. Materials and Methods: We identified 791 patients with HGPIN on the initial biopsy who had a followup biopsy within 1 year of their diagnosis. The mean interval from diagnosis of HGPIN to re-biopsy was 4.6 months. In the initial biopsy with HGPIN, 323 men had 8 or more cores (median 10, range 8 to 26) and 332 men had 6 core biopsies. Results: In the 6 core initial sampling group, the risk of cancer on re-biopsy was 20.8% compared to only 13.3% following an initial 8 core or more sampling (p = 0.011). With 6 core biopsies for both the initial and re-biopsy the risk of cancer was 14.1% (group 1). With an initial 6 core biopsy and 8 core or more biopsy on followup, the risk of cancer was 31.9% (group 2). With 8 core or more biopsy sampling for both initial and repeat biopsies, the risk for cancer was 14.6% (group 3). The differences between groups 1 and 3 as compared to group 2 were statistically significant (p = 0.001 and p

Original languageEnglish (US)
Pages (from-to)121-124
Number of pages4
JournalJournal of Urology
Volume175
Issue number1
DOIs
StatePublished - Jan 2006

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Prostatic Intraepithelial Neoplasia
Prostatic Neoplasms
Biopsy
Neoplasms
Needle Biopsy

Keywords

  • Biopsy
  • Prostatic intraepithelial neoplasia
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Risk of prostate cancer on first re-biopsy within 1 year following a diagnosis of high grade prostatic intraepithelial neoplasia is related to the number of cores sampled. / Herawi, Mehsati; Kahane, Hillel; Cavallo, Christina; Epstein, Jonathan Ira.

In: Journal of Urology, Vol. 175, No. 1, 01.2006, p. 121-124.

Research output: Contribution to journalArticle

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abstract = "Purpose: We determined the influence of the extent of needle biopsy sampling on the detection rate of cancer on first biopsy within 1 year following a diagnosis of HGPIN. Materials and Methods: We identified 791 patients with HGPIN on the initial biopsy who had a followup biopsy within 1 year of their diagnosis. The mean interval from diagnosis of HGPIN to re-biopsy was 4.6 months. In the initial biopsy with HGPIN, 323 men had 8 or more cores (median 10, range 8 to 26) and 332 men had 6 core biopsies. Results: In the 6 core initial sampling group, the risk of cancer on re-biopsy was 20.8{\%} compared to only 13.3{\%} following an initial 8 core or more sampling (p = 0.011). With 6 core biopsies for both the initial and re-biopsy the risk of cancer was 14.1{\%} (group 1). With an initial 6 core biopsy and 8 core or more biopsy on followup, the risk of cancer was 31.9{\%} (group 2). With 8 core or more biopsy sampling for both initial and repeat biopsies, the risk for cancer was 14.6{\%} (group 3). The differences between groups 1 and 3 as compared to group 2 were statistically significant (p = 0.001 and p",
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AU - Epstein, Jonathan Ira

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AB - Purpose: We determined the influence of the extent of needle biopsy sampling on the detection rate of cancer on first biopsy within 1 year following a diagnosis of HGPIN. Materials and Methods: We identified 791 patients with HGPIN on the initial biopsy who had a followup biopsy within 1 year of their diagnosis. The mean interval from diagnosis of HGPIN to re-biopsy was 4.6 months. In the initial biopsy with HGPIN, 323 men had 8 or more cores (median 10, range 8 to 26) and 332 men had 6 core biopsies. Results: In the 6 core initial sampling group, the risk of cancer on re-biopsy was 20.8% compared to only 13.3% following an initial 8 core or more sampling (p = 0.011). With 6 core biopsies for both the initial and re-biopsy the risk of cancer was 14.1% (group 1). With an initial 6 core biopsy and 8 core or more biopsy on followup, the risk of cancer was 31.9% (group 2). With 8 core or more biopsy sampling for both initial and repeat biopsies, the risk for cancer was 14.6% (group 3). The differences between groups 1 and 3 as compared to group 2 were statistically significant (p = 0.001 and p

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