Risk of prostate cancer in African-American men: Evidence of mixed effects of dietary quercetin by serum Vitamin D status

Channing Paller, Y. M. Kanaan, D. A. Beyene, T. J. Naab, R. L. Copeland, H. L. Tsai, Norma F Kanarek, T. S. Hudson

Research output: Contribution to journalArticle

Abstract

BACKGROUND African-American (AA) men experience higher rates of prostate cancer (PCa) and vitamin D (vitD) deficiency than white men. VitD is promoted for PCa prevention, but there is conflicting data on the association between vitD and PCa. We examined the association between serum vitD and dietary quercetin and their interaction with PCa risk in AA men. METHODS Participants included 90 AA men with PCa undergoing treatment at Howard University Hospital (HUH) and 62 controls participating in HUH's free PCa screening program. We measured serum 25-hydroxy vitD [25(OH)D] and used the 98.2 item Block Brief 2000 Food Frequency Questionnaires to measure dietary intake of quercetin and other nutrients. Case and control groups were compared using a two-sample t-test for continuous risk factors and a Fisher exact test for categorical factors. Associations between risk factors and PCa risk were examined via age-adjusted logistic regression models. RESULTS Interaction effects of dietary quercetin and serum vitD on PCa status were observed. AA men (age 40-70) with normal levels of serum vitD (>30-ng/ml) had a 71% lower risk of PCa compared to AA men with vitD deficiency (OR-=-0.29, 95%CI: 0.08-1.03; P-=-0.055). In individuals with vitD deficiency, increased dietary quercetin showed a tendency toward lower risk of PCa (OR-=-0.91, 95%CI: 0.82-1.00; P-=-0.054, age-adjusted) while men with normal vitD were at elevated risk (OR-=-1.23, 95%CI: 1.04-1.45). CONCLUSION These findings suggest that AA men who are at a higher risk of PCa may benefit more from vitD intake, and supplementation with dietary quercetin may increase the risk of PCa in AA men with normal vitD levels. Further studies with larger populations are needed to better understand the impact of the interaction between sera vitD levels and supplementation with quercetin on PCa in AA men.

Original languageEnglish (US)
Pages (from-to)1376-1383
Number of pages8
JournalProstate
Volume75
Issue number13
DOIs
StatePublished - Sep 1 2015

Fingerprint

Quercetin
Vitamin D
African Americans
Prostatic Neoplasms
Serum
Vitamin D Deficiency
Logistic Models
Food
Dietary Supplements
Early Detection of Cancer

Keywords

  • African-American
  • prostate cancer
  • quercetin
  • Vitamin D

ASJC Scopus subject areas

  • Urology
  • Oncology

Cite this

Paller, C., Kanaan, Y. M., Beyene, D. A., Naab, T. J., Copeland, R. L., Tsai, H. L., ... Hudson, T. S. (2015). Risk of prostate cancer in African-American men: Evidence of mixed effects of dietary quercetin by serum Vitamin D status. Prostate, 75(13), 1376-1383. https://doi.org/10.1002/pros.23018

Risk of prostate cancer in African-American men : Evidence of mixed effects of dietary quercetin by serum Vitamin D status. / Paller, Channing; Kanaan, Y. M.; Beyene, D. A.; Naab, T. J.; Copeland, R. L.; Tsai, H. L.; Kanarek, Norma F; Hudson, T. S.

In: Prostate, Vol. 75, No. 13, 01.09.2015, p. 1376-1383.

Research output: Contribution to journalArticle

Paller, Channing ; Kanaan, Y. M. ; Beyene, D. A. ; Naab, T. J. ; Copeland, R. L. ; Tsai, H. L. ; Kanarek, Norma F ; Hudson, T. S. / Risk of prostate cancer in African-American men : Evidence of mixed effects of dietary quercetin by serum Vitamin D status. In: Prostate. 2015 ; Vol. 75, No. 13. pp. 1376-1383.
@article{18f77ea3b51741f99bb4de7c33905dd3,
title = "Risk of prostate cancer in African-American men: Evidence of mixed effects of dietary quercetin by serum Vitamin D status",
abstract = "BACKGROUND African-American (AA) men experience higher rates of prostate cancer (PCa) and vitamin D (vitD) deficiency than white men. VitD is promoted for PCa prevention, but there is conflicting data on the association between vitD and PCa. We examined the association between serum vitD and dietary quercetin and their interaction with PCa risk in AA men. METHODS Participants included 90 AA men with PCa undergoing treatment at Howard University Hospital (HUH) and 62 controls participating in HUH's free PCa screening program. We measured serum 25-hydroxy vitD [25(OH)D] and used the 98.2 item Block Brief 2000 Food Frequency Questionnaires to measure dietary intake of quercetin and other nutrients. Case and control groups were compared using a two-sample t-test for continuous risk factors and a Fisher exact test for categorical factors. Associations between risk factors and PCa risk were examined via age-adjusted logistic regression models. RESULTS Interaction effects of dietary quercetin and serum vitD on PCa status were observed. AA men (age 40-70) with normal levels of serum vitD (>30-ng/ml) had a 71{\%} lower risk of PCa compared to AA men with vitD deficiency (OR-=-0.29, 95{\%}CI: 0.08-1.03; P-=-0.055). In individuals with vitD deficiency, increased dietary quercetin showed a tendency toward lower risk of PCa (OR-=-0.91, 95{\%}CI: 0.82-1.00; P-=-0.054, age-adjusted) while men with normal vitD were at elevated risk (OR-=-1.23, 95{\%}CI: 1.04-1.45). CONCLUSION These findings suggest that AA men who are at a higher risk of PCa may benefit more from vitD intake, and supplementation with dietary quercetin may increase the risk of PCa in AA men with normal vitD levels. Further studies with larger populations are needed to better understand the impact of the interaction between sera vitD levels and supplementation with quercetin on PCa in AA men.",
keywords = "African-American, prostate cancer, quercetin, Vitamin D",
author = "Channing Paller and Kanaan, {Y. M.} and Beyene, {D. A.} and Naab, {T. J.} and Copeland, {R. L.} and Tsai, {H. L.} and Kanarek, {Norma F} and Hudson, {T. S.}",
year = "2015",
month = "9",
day = "1",
doi = "10.1002/pros.23018",
language = "English (US)",
volume = "75",
pages = "1376--1383",
journal = "Prostate",
issn = "0270-4137",
publisher = "Wiley-Liss Inc.",
number = "13",

}

TY - JOUR

T1 - Risk of prostate cancer in African-American men

T2 - Evidence of mixed effects of dietary quercetin by serum Vitamin D status

AU - Paller, Channing

AU - Kanaan, Y. M.

AU - Beyene, D. A.

AU - Naab, T. J.

AU - Copeland, R. L.

AU - Tsai, H. L.

AU - Kanarek, Norma F

AU - Hudson, T. S.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - BACKGROUND African-American (AA) men experience higher rates of prostate cancer (PCa) and vitamin D (vitD) deficiency than white men. VitD is promoted for PCa prevention, but there is conflicting data on the association between vitD and PCa. We examined the association between serum vitD and dietary quercetin and their interaction with PCa risk in AA men. METHODS Participants included 90 AA men with PCa undergoing treatment at Howard University Hospital (HUH) and 62 controls participating in HUH's free PCa screening program. We measured serum 25-hydroxy vitD [25(OH)D] and used the 98.2 item Block Brief 2000 Food Frequency Questionnaires to measure dietary intake of quercetin and other nutrients. Case and control groups were compared using a two-sample t-test for continuous risk factors and a Fisher exact test for categorical factors. Associations between risk factors and PCa risk were examined via age-adjusted logistic regression models. RESULTS Interaction effects of dietary quercetin and serum vitD on PCa status were observed. AA men (age 40-70) with normal levels of serum vitD (>30-ng/ml) had a 71% lower risk of PCa compared to AA men with vitD deficiency (OR-=-0.29, 95%CI: 0.08-1.03; P-=-0.055). In individuals with vitD deficiency, increased dietary quercetin showed a tendency toward lower risk of PCa (OR-=-0.91, 95%CI: 0.82-1.00; P-=-0.054, age-adjusted) while men with normal vitD were at elevated risk (OR-=-1.23, 95%CI: 1.04-1.45). CONCLUSION These findings suggest that AA men who are at a higher risk of PCa may benefit more from vitD intake, and supplementation with dietary quercetin may increase the risk of PCa in AA men with normal vitD levels. Further studies with larger populations are needed to better understand the impact of the interaction between sera vitD levels and supplementation with quercetin on PCa in AA men.

AB - BACKGROUND African-American (AA) men experience higher rates of prostate cancer (PCa) and vitamin D (vitD) deficiency than white men. VitD is promoted for PCa prevention, but there is conflicting data on the association between vitD and PCa. We examined the association between serum vitD and dietary quercetin and their interaction with PCa risk in AA men. METHODS Participants included 90 AA men with PCa undergoing treatment at Howard University Hospital (HUH) and 62 controls participating in HUH's free PCa screening program. We measured serum 25-hydroxy vitD [25(OH)D] and used the 98.2 item Block Brief 2000 Food Frequency Questionnaires to measure dietary intake of quercetin and other nutrients. Case and control groups were compared using a two-sample t-test for continuous risk factors and a Fisher exact test for categorical factors. Associations between risk factors and PCa risk were examined via age-adjusted logistic regression models. RESULTS Interaction effects of dietary quercetin and serum vitD on PCa status were observed. AA men (age 40-70) with normal levels of serum vitD (>30-ng/ml) had a 71% lower risk of PCa compared to AA men with vitD deficiency (OR-=-0.29, 95%CI: 0.08-1.03; P-=-0.055). In individuals with vitD deficiency, increased dietary quercetin showed a tendency toward lower risk of PCa (OR-=-0.91, 95%CI: 0.82-1.00; P-=-0.054, age-adjusted) while men with normal vitD were at elevated risk (OR-=-1.23, 95%CI: 1.04-1.45). CONCLUSION These findings suggest that AA men who are at a higher risk of PCa may benefit more from vitD intake, and supplementation with dietary quercetin may increase the risk of PCa in AA men with normal vitD levels. Further studies with larger populations are needed to better understand the impact of the interaction between sera vitD levels and supplementation with quercetin on PCa in AA men.

KW - African-American

KW - prostate cancer

KW - quercetin

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=84939269760&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939269760&partnerID=8YFLogxK

U2 - 10.1002/pros.23018

DO - 10.1002/pros.23018

M3 - Article

C2 - 26047130

AN - SCOPUS:84939269760

VL - 75

SP - 1376

EP - 1383

JO - Prostate

JF - Prostate

SN - 0270-4137

IS - 13

ER -