Risk of Multiple Sclerosis Exacerbation During Pregnancy and Breast-feeding

Lorene M. Nelson; Gary M. Franklin; Monica C. Jones; George Belendiuk; Barbara Kasper; Diane Klatzman; William Mietlowski; Suzanne Solch; Gary Franklin; Jack Burks; Lorene Nelson; Carolyn Wangaard; Henry Mcfarland; Andrew Goodman; [No Value] Dale; Helen Krebs; Heidi Maloni; Joe Debronozo; [No Value] Labe; Ute Traugott; Mindy Aisen; Kate Robbins; William Sibley; Jose Laguna; Joan Laguna; [No Value] John; David Cliford; Larry Smith; Jane Mclnnis; Barry Arnason; Raymond Roos; Anthony Reder; Jack Antel; Mark Aguis; Roberta Martia; Barrie Hurwitz; Steven Greenburg; Louis Fredane; Rebecca Herbstreith; Jean Hurwitz; Kenneth Johnson; Hillel Panitch; Carol Lee Koski; Paul Fishman; Sue Haley; Jack Petajan; Patrick Bray; John Rose; David Thurman; William Galster; Wallace Tourtellotte; R. W. Baumhefner; George Ellison; Lawrence Myers; Karl Syndulko; Lavona Newton; Jerry Wolinsky; E. Simon Sears; Avindra Nath; Catherine Weisbrodt

doi:10.1001/jama.1988.03720230051029

Risk of Multiple Sclerosis Exacerbation During Pregnancy and Breast-feeding

Lorene M. Nelson, Gary M. Franklin, Monica C. Jones, George Belendiuk, Barbara Kasper, Diane Klatzman, William Mietlowski, Suzanne Solch, Gary Franklin, Jack Burks, Lorene Nelson, Carolyn Wangaard, Henry Mcfarland, Andrew Goodman, [No Value] Dale, Helen Krebs, Heidi Maloni, Joe Debronozo, [No Value] Labe, Ute TraugottMindy Aisen, Kate Robbins, William Sibley, Jose Laguna, Joan Laguna, [No Value] John, David Cliford, Larry Smith, Jane Mclnnis, Barry Arnason, Raymond Roos, Anthony Reder, Jack Antel, Mark Aguis, Roberta Martia, Barrie Hurwitz, Steven Greenburg, Louis Fredane, Rebecca Herbstreith, Jean Hurwitz, Kenneth Johnson, Hillel Panitch, Carol Lee Koski, Paul Fishman, Sue Haley, Jack Petajan, Patrick Bray, John Rose, David Thurman, William Galster, Wallace Tourtellotte, R. W. Baumhefner, George Ellison, Lawrence Myers, Karl Syndulko, Lavona Newton, Jerry Wolinsky, E. Simon Sears, Avindra Nath, Catherine Weisbrodt

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Abstract

Studies in the past have reported an increased risk of exacerbations in multiple sclerosis during the postpartum period; it is not known whether breast-feeding alters this risk. We interviewed 435 women regarding pregnancy and breast-feeding history, providing for analysis 191 pregnancies that had occurred during a nonprogressive phase of the disease. The exacerbation rates during the nine-month postpartum period (34%) were more than three times the exacerbation rate during the nine months of pregnancy (10%). The exacerbation risk was highest in the three-month period following childbirth and appeared to stabilize after the sixth postpartum month. The exacerbation rates in breast-feeding and non—breast-feeding pregnancies were 38% and 31%, respectively. The average time to exacerbation was similar in breast-feeding (3.0 months) and non—breast-feeding (3.1 months) pregnancies. Although differential exacerbation rates during pregnancy and the postpartum period may be related to hormonal effects on the immune system, the hormonal effects of breast-feeding do not appear to similarly affect the risk of exacerbation.

Original language	English (US)
Pages (from-to)	3441-3443
Number of pages	3
Journal	Journal of the American Medical Association
Volume	259
Issue number	23
DOIs	https://doi.org/10.1001/jama.1988.03720230051029
State	Published - Jun 17 1988
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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Nelson, L. M., Franklin, G. M., Jones, M. C., Belendiuk, G., Kasper, B., Klatzman, D., Mietlowski, W., Solch, S., Franklin, G., Burks, J., Nelson, L., Wangaard, C., Mcfarland, H., Goodman, A., Dale, N. V., Krebs, H., Maloni, H., Debronozo, J., Labe, N. V., ... Weisbrodt, C. (1988). Risk of Multiple Sclerosis Exacerbation During Pregnancy and Breast-feeding. Journal of the American Medical Association, 259(23), 3441-3443. https://doi.org/10.1001/jama.1988.03720230051029

Nelson, LM, Franklin, GM, Jones, MC, Belendiuk, G, Kasper, B, Klatzman, D, Mietlowski, W, Solch, S, Franklin, G, Burks, J, Nelson, L, Wangaard, C, Mcfarland, H, Goodman, A, Dale, NV, Krebs, H, Maloni, H, Debronozo, J, Labe, NV, Traugott, U, Aisen, M, Robbins, K, Sibley, W, Laguna, J, Laguna, J, John, NV, Cliford, D, Smith, L, Mclnnis, J, Arnason, B, Roos, R, Reder, A, Antel, J, Aguis, M, Martia, R, Hurwitz, B, Greenburg, S, Fredane, L, Herbstreith, R, Hurwitz, J, Johnson, K, Panitch, H, Koski, CL, Fishman, P, Haley, S, Petajan, J, Bray, P, Rose, J, Thurman, D, Galster, W, Tourtellotte, W, Baumhefner, RW, Ellison, G, Myers, L, Syndulko, K, Newton, L, Wolinsky, J, Sears, ES, Nath, A & Weisbrodt, C 1988, 'Risk of Multiple Sclerosis Exacerbation During Pregnancy and Breast-feeding', Journal of the American Medical Association, vol. 259, no. 23, pp. 3441-3443. https://doi.org/10.1001/jama.1988.03720230051029

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title = "Risk of Multiple Sclerosis Exacerbation During Pregnancy and Breast-feeding",

abstract = "Studies in the past have reported an increased risk of exacerbations in multiple sclerosis during the postpartum period; it is not known whether breast-feeding alters this risk. We interviewed 435 women regarding pregnancy and breast-feeding history, providing for analysis 191 pregnancies that had occurred during a nonprogressive phase of the disease. The exacerbation rates during the nine-month postpartum period (34%) were more than three times the exacerbation rate during the nine months of pregnancy (10%). The exacerbation risk was highest in the three-month period following childbirth and appeared to stabilize after the sixth postpartum month. The exacerbation rates in breast-feeding and non—breast-feeding pregnancies were 38% and 31%, respectively. The average time to exacerbation was similar in breast-feeding (3.0 months) and non—breast-feeding (3.1 months) pregnancies. Although differential exacerbation rates during pregnancy and the postpartum period may be related to hormonal effects on the immune system, the hormonal effects of breast-feeding do not appear to similarly affect the risk of exacerbation.",

author = "Nelson, {Lorene M.} and Franklin, {Gary M.} and Jones, {Monica C.} and George Belendiuk and Barbara Kasper and Diane Klatzman and William Mietlowski and Suzanne Solch and Gary Franklin and Jack Burks and Lorene Nelson and Carolyn Wangaard and Henry Mcfarland and Andrew Goodman and Dale, {[No Value]} and Helen Krebs and Heidi Maloni and Joe Debronozo and Labe, {[No Value]} and Ute Traugott and Mindy Aisen and Kate Robbins and William Sibley and Jose Laguna and Joan Laguna and John, {[No Value]} and David Cliford and Larry Smith and Jane Mclnnis and Barry Arnason and Raymond Roos and Anthony Reder and Jack Antel and Mark Aguis and Roberta Martia and Barrie Hurwitz and Steven Greenburg and Louis Fredane and Rebecca Herbstreith and Jean Hurwitz and Kenneth Johnson and Hillel Panitch and Koski, {Carol Lee} and Paul Fishman and Sue Haley and Jack Petajan and Patrick Bray and John Rose and David Thurman and William Galster and Wallace Tourtellotte and Baumhefner, {R. W.} and George Ellison and Lawrence Myers and Karl Syndulko and Lavona Newton and Jerry Wolinsky and Sears, {E. Simon} and Avindra Nath and Catherine Weisbrodt",

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doi = "10.1001/jama.1988.03720230051029",

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AU - Kasper, Barbara

AU - Klatzman, Diane

AU - Mietlowski, William

AU - Solch, Suzanne

AU - Franklin, Gary

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AU - Nelson, Lorene

AU - Wangaard, Carolyn

AU - Mcfarland, Henry

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AU - Dale, [No Value]

AU - Krebs, Helen

AU - Maloni, Heidi

AU - Debronozo, Joe

AU - Labe, [No Value]

AU - Traugott, Ute

AU - Aisen, Mindy

AU - Robbins, Kate

AU - Sibley, William

AU - Laguna, Jose

AU - Laguna, Joan

AU - John, [No Value]

AU - Cliford, David

AU - Smith, Larry

AU - Mclnnis, Jane

AU - Arnason, Barry

AU - Roos, Raymond

AU - Reder, Anthony

AU - Antel, Jack

AU - Aguis, Mark

AU - Martia, Roberta

AU - Hurwitz, Barrie

AU - Greenburg, Steven

AU - Fredane, Louis

AU - Herbstreith, Rebecca

AU - Hurwitz, Jean

AU - Johnson, Kenneth

AU - Panitch, Hillel

AU - Koski, Carol Lee

AU - Fishman, Paul

AU - Haley, Sue

AU - Petajan, Jack

AU - Bray, Patrick

AU - Rose, John

AU - Thurman, David

AU - Galster, William

AU - Tourtellotte, Wallace

AU - Baumhefner, R. W.

AU - Ellison, George

AU - Myers, Lawrence

AU - Syndulko, Karl

AU - Newton, Lavona

AU - Wolinsky, Jerry

AU - Sears, E. Simon

AU - Nath, Avindra

AU - Weisbrodt, Catherine

PY - 1988/6/17

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N2 - Studies in the past have reported an increased risk of exacerbations in multiple sclerosis during the postpartum period; it is not known whether breast-feeding alters this risk. We interviewed 435 women regarding pregnancy and breast-feeding history, providing for analysis 191 pregnancies that had occurred during a nonprogressive phase of the disease. The exacerbation rates during the nine-month postpartum period (34%) were more than three times the exacerbation rate during the nine months of pregnancy (10%). The exacerbation risk was highest in the three-month period following childbirth and appeared to stabilize after the sixth postpartum month. The exacerbation rates in breast-feeding and non—breast-feeding pregnancies were 38% and 31%, respectively. The average time to exacerbation was similar in breast-feeding (3.0 months) and non—breast-feeding (3.1 months) pregnancies. Although differential exacerbation rates during pregnancy and the postpartum period may be related to hormonal effects on the immune system, the hormonal effects of breast-feeding do not appear to similarly affect the risk of exacerbation.

AB - Studies in the past have reported an increased risk of exacerbations in multiple sclerosis during the postpartum period; it is not known whether breast-feeding alters this risk. We interviewed 435 women regarding pregnancy and breast-feeding history, providing for analysis 191 pregnancies that had occurred during a nonprogressive phase of the disease. The exacerbation rates during the nine-month postpartum period (34%) were more than three times the exacerbation rate during the nine months of pregnancy (10%). The exacerbation risk was highest in the three-month period following childbirth and appeared to stabilize after the sixth postpartum month. The exacerbation rates in breast-feeding and non—breast-feeding pregnancies were 38% and 31%, respectively. The average time to exacerbation was similar in breast-feeding (3.0 months) and non—breast-feeding (3.1 months) pregnancies. Although differential exacerbation rates during pregnancy and the postpartum period may be related to hormonal effects on the immune system, the hormonal effects of breast-feeding do not appear to similarly affect the risk of exacerbation.

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Risk of Multiple Sclerosis Exacerbation During Pregnancy and Breast-feeding

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