Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types

James J. Goedert, Hong Chuan Li, Xiao Jiang Gao, Nilanjan Chatterjee, Shunro Sonoda, Robert J. Biggar, Beverley Cranston, Norma Kim, Mary Carrington, Owen Morgan, Barrie Hanchard, Michie Hisada

Research output: Contribution to journalArticle

Abstract

Human T-lymphotropic virus-I (HTLV-I) causes adult T-cell leukemia/lymphoma (ATL) and HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We postulated a higher disease risk for people with common human leukocyte antigen (HLA) types, due to a narrower immune response against viral or neoplastic antigens, compared to people with uncommon types. HLA class-I (A,B) and class-II (DRB1, DQB1) allele and haplotype frequencies in 56 ATL patients, 59 HAM/TSP patients and 190 population-based, asymptomatic HTLV-I-infected carriers were compared by logistic regression overall (score test) and with odds ratios (ORs) for common types (prevalence >50% of asymptomatic carriers) and by prevalence quartile. HTLV-I proviral load between asymptomatic carriers with common versus uncommon types was compared by t-test. ATL differed from asymptomatic carriers in overall DQB1 allele and class-I haplotype frequencies (p ≤ 0.04). ATL risk was increased significantly with common HLA-B (OR 2.25, 95% CI 1.19-4.25) and DRB1 (OR 2.11, 95% CI 1.13-3.40) alleles. Higher prevalence HLA-B alleles were associated with higher ATL risk (OR 1.14 per quartile, ptrend = 0.02). Asymptomatic carriers with common HLA-B alleles had marginally higher HTLV-I proviral load (p = 0.057). HAM/TSP risk did not differ consistently with common HLA types. Thus, ATL risk, but not HAM/TSP risk, was increased with higher prevalence HLA-B alleles. Perhaps breadth of cellular immunity affects risk of this viral leukemia lymphoma.

Original languageEnglish (US)
Pages (from-to)1092-1097
Number of pages6
JournalInternational Journal of Cancer
Volume121
Issue number5
DOIs
StatePublished - Sep 1 2007
Externally publishedYes

Keywords

  • Human T-lymphotropic virus type I (HTLV-I)
  • Human leukocyte antigens (HLA)
  • Myelopathy
  • T-cell lymphoma
  • Viral load

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Goedert, J. J., Li, H. C., Gao, X. J., Chatterjee, N., Sonoda, S., Biggar, R. J., Cranston, B., Kim, N., Carrington, M., Morgan, O., Hanchard, B., & Hisada, M. (2007). Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types. International Journal of Cancer, 121(5), 1092-1097. https://doi.org/10.1002/ijc.22767