Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: Results of a Canadian collaboratlve study

P. C. Rowe; E. Orrbine; H. Lior; G. A. Wells; E. Yetisir; M. Clulow; P. N. McLaine; J. Carter; D. Lirenman; J. Anderson; L. Robson; C. Trevenen; G. Cadrain; D. Miller-Hughes; N. Henning; C. Anand; R. Gordon; J. Cumming; F. Harley; P. Kibsey; R. Rennie; P. Pearce; D. McClellan; D. Hasinoff; W. L. Albritton; M. Richter; H. Tabor; M. Lovgren; G. Kasian; S. Scott; B. Andreychuk; M. Bingham; L. Currie; B. Homes; E. Thomas; M. McNaughton; M. Ogborn; P. Grimm; D. Hoaban; R. Walker; S. Sareen; G. Hammond; T. Williams; W. Winther; W. Clark; R. Lannigan; K. Manarin; A. Parbtani; R. M. Hurley; D. G. Matsell; T. Devuono; J. Loft; J. Fase; A. Reid; B. Steele; F. Smaill; C. Jones; L. F. Jones; M. Karmali; J. W. Balfe; A. Eddy; D. Geary; E. Harvey; D. Hebert; K. Skorecki; M. Winkler; V. Lapp; S. Cox; D. Alexander; G. Delisle; E. Toffelmire; L. Tomalty; B. Kilbred; P. Morrin; M. Singer; Y. Peterson; F. Chan; N. Wolfish; A. MacKenzie; L. Fuite; L. Hyde; B. Ng; C. DeJesus; N. Le Saux; M. Stewart; E. Ellis; K. Goodver; S. Trifiro; K. Drummond; L. Bell; D. Laforte; S. O'Reagan; P. Robitaille; J. G. Mongeau; J. Clermont; J. Letourneau; G. Douville; M. Brown; L. Cote

doi:10.1016/S0022-3476(98)70303-8

Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: Results of a Canadian collaboratlve study

P. C. Rowe, E. Orrbine, H. Lior, G. A. Wells, E. Yetisir, M. Clulow, P. N. McLaine, J. Carter, D. Lirenman, J. Anderson, L. Robson, C. Trevenen, G. Cadrain, D. Miller-Hughes, N. Henning, C. Anand, R. Gordon, J. Cumming, F. Harley, P. KibseyR. Rennie, P. Pearce, D. McClellan, D. Hasinoff, W. L. Albritton, M. Richter, H. Tabor, M. Lovgren, G. Kasian, S. Scott, B. Andreychuk, M. Bingham, L. Currie, B. Homes, E. Thomas, M. McNaughton, M. Ogborn, P. Grimm, D. Hoaban, R. Walker, S. Sareen, G. Hammond, T. Williams, W. Winther, W. Clark, R. Lannigan, K. Manarin, A. Parbtani, R. M. Hurley, D. G. Matsell, T. Devuono, J. Loft, J. Fase, A. Reid, B. Steele, F. Smaill, C. Jones, L. F. Jones, M. Karmali, J. W. Balfe, A. Eddy, D. Geary, E. Harvey, D. Hebert, K. Skorecki, M. Winkler, V. Lapp, S. Cox, D. Alexander, G. Delisle, E. Toffelmire, L. Tomalty, B. Kilbred, P. Morrin, M. Singer, Y. Peterson, F. Chan, N. Wolfish, A. MacKenzie, L. Fuite, L. Hyde, B. Ng, C. DeJesus, N. Le Saux, M. Stewart, E. Ellis, K. Goodver, S. Trifiro, K. Drummond, L. Bell, D. Laforte, S. O'Reagan, P. Robitaille, J. G. Mongeau, J. Clermont, J. Letourneau, G. Douville, M. Brown, L. Cote

Research output: Contribution to journal › Article › peer-review

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Abstract

Objectives: The objectives of this study were to better estimate the age-specific risks of hemolytic uremic syndrome (HUS) and hemolytic anemia after Escherichia coli O157:H7 infection among a representative cohort of both referred and nonreferred children with documented illness from the province of Alberta and to compare this with the rates in children evaluated at referral centers in the rest of Canada. Study design: Children with H US or E. coli O157:H7 gastroenteritis were eligible if they were <15 years of age. Hemoglobin, blood smear, urinalysis, and serum creatinine were obtained 8 to 10 days after the onset of diarrhea to ascertain for hemolysis, anemia, thrombocytopenia, and renal injury. Subjects were monitored for 1 month. Results: From June 1991 to March 1994, HUS was diagnosed in 205 children. Of these 77% had evidence or E. coli O157:H7 infection. A further 582 children had E. coli O157:H7 gastroenteritis, of whom 18 had hemolytic anemia. The risk of HUS after E. coli O157:H7 infection in Alberta was 8.1% (95% confidence interval, 5.3 to 11.6) compared with 31.4% in referral centers in the rest of Canada. In Alberta the highest age-specific risk f HUS/hemolytic anemia was 12.9% in those <5 years of age. Conclusions: These data will help guide clinical care and provide a basis for estimating the sample sizes required in future treatment trials for the secondary prevention of 11 US.

Original language	English (US)
Pages (from-to)	777-782
Number of pages	6
Journal	Journal of Pediatrics
Volume	132
Issue number	5
DOIs	https://doi.org/10.1016/S0022-3476(98)70303-8
State	Published - 1998
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(98)70303-8

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Rowe, P. C., Orrbine, E., Lior, H., Wells, G. A., Yetisir, E., Clulow, M., McLaine, P. N., Carter, J., Lirenman, D., Anderson, J., Robson, L., Trevenen, C., Cadrain, G., Miller-Hughes, D., Henning, N., Anand, C., Gordon, R., Cumming, J., Harley, F., ... Cote, L. (1998). Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: Results of a Canadian collaboratlve study. Journal of Pediatrics, 132(5), 777-782. https://doi.org/10.1016/S0022-3476(98)70303-8

Rowe, PC, Orrbine, E, Lior, H, Wells, GA, Yetisir, E, Clulow, M, McLaine, PN, Carter, J, Lirenman, D, Anderson, J, Robson, L, Trevenen, C, Cadrain, G, Miller-Hughes, D, Henning, N, Anand, C, Gordon, R, Cumming, J, Harley, F, Kibsey, P, Rennie, R, Pearce, P, McClellan, D, Hasinoff, D, Albritton, WL, Richter, M, Tabor, H, Lovgren, M, Kasian, G, Scott, S, Andreychuk, B, Bingham, M, Currie, L, Homes, B, Thomas, E, McNaughton, M, Ogborn, M, Grimm, P, Hoaban, D, Walker, R, Sareen, S, Hammond, G, Williams, T, Winther, W, Clark, W, Lannigan, R, Manarin, K, Parbtani, A, Hurley, RM, Matsell, DG, Devuono, T, Loft, J, Fase, J, Reid, A, Steele, B, Smaill, F, Jones, C, Jones, LF, Karmali, M, Balfe, JW, Eddy, A, Geary, D, Harvey, E, Hebert, D, Skorecki, K, Winkler, M, Lapp, V, Cox, S, Alexander, D, Delisle, G, Toffelmire, E, Tomalty, L, Kilbred, B, Morrin, P, Singer, M, Peterson, Y, Chan, F, Wolfish, N, MacKenzie, A, Fuite, L, Hyde, L, Ng, B, DeJesus, C, Le Saux, N, Stewart, M, Ellis, E, Goodver, K, Trifiro, S, Drummond, K, Bell, L, Laforte, D, O'Reagan, S, Robitaille, P, Mongeau, JG, Clermont, J, Letourneau, J, Douville, G, Brown, M & Cote, L 1998, 'Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: Results of a Canadian collaboratlve study', Journal of Pediatrics, vol. 132, no. 5, pp. 777-782. https://doi.org/10.1016/S0022-3476(98)70303-8

@article{a2ae6f5f6e344cddb74b938eb782eccb,

title = "Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: Results of a Canadian collaboratlve study",

abstract = "Objectives: The objectives of this study were to better estimate the age-specific risks of hemolytic uremic syndrome (HUS) and hemolytic anemia after Escherichia coli O157:H7 infection among a representative cohort of both referred and nonreferred children with documented illness from the province of Alberta and to compare this with the rates in children evaluated at referral centers in the rest of Canada. Study design: Children with H US or E. coli O157:H7 gastroenteritis were eligible if they were <15 years of age. Hemoglobin, blood smear, urinalysis, and serum creatinine were obtained 8 to 10 days after the onset of diarrhea to ascertain for hemolysis, anemia, thrombocytopenia, and renal injury. Subjects were monitored for 1 month. Results: From June 1991 to March 1994, HUS was diagnosed in 205 children. Of these 77% had evidence or E. coli O157:H7 infection. A further 582 children had E. coli O157:H7 gastroenteritis, of whom 18 had hemolytic anemia. The risk of HUS after E. coli O157:H7 infection in Alberta was 8.1% (95% confidence interval, 5.3 to 11.6) compared with 31.4% in referral centers in the rest of Canada. In Alberta the highest age-specific risk f HUS/hemolytic anemia was 12.9% in those <5 years of age. Conclusions: These data will help guide clinical care and provide a basis for estimating the sample sizes required in future treatment trials for the secondary prevention of 11 US.",

author = "Rowe, {P. C.} and E. Orrbine and H. Lior and Wells, {G. A.} and E. Yetisir and M. Clulow and McLaine, {P. N.} and J. Carter and D. Lirenman and J. Anderson and L. Robson and C. Trevenen and G. Cadrain and D. Miller-Hughes and N. Henning and C. Anand and R. Gordon and J. Cumming and F. Harley and P. Kibsey and R. Rennie and P. Pearce and D. McClellan and D. Hasinoff and Albritton, {W. L.} and M. Richter and H. Tabor and M. Lovgren and G. Kasian and S. Scott and B. Andreychuk and M. Bingham and L. Currie and B. Homes and E. Thomas and M. McNaughton and M. Ogborn and P. Grimm and D. Hoaban and R. Walker and S. Sareen and G. Hammond and T. Williams and W. Winther and W. Clark and R. Lannigan and K. Manarin and A. Parbtani and Hurley, {R. M.} and Matsell, {D. G.} and T. Devuono and J. Loft and J. Fase and A. Reid and B. Steele and F. Smaill and C. Jones and Jones, {L. F.} and M. Karmali and Balfe, {J. W.} and A. Eddy and D. Geary and E. Harvey and D. Hebert and K. Skorecki and M. Winkler and V. Lapp and S. Cox and D. Alexander and G. Delisle and E. Toffelmire and L. Tomalty and B. Kilbred and P. Morrin and M. Singer and Y. Peterson and F. Chan and N. Wolfish and A. MacKenzie and L. Fuite and L. Hyde and B. Ng and C. DeJesus and {Le Saux}, N. and M. Stewart and E. Ellis and K. Goodver and S. Trifiro and K. Drummond and L. Bell and D. Laforte and S. O'Reagan and P. Robitaille and Mongeau, {J. G.} and J. Clermont and J. Letourneau and G. Douville and M. Brown and L. Cote",

note = "Funding Information: Supported by a grant (6606-4519-54) from the National Health Research and Development Program, Health and Welfare Canada and in part by a Career Scientist Award to Dr. Rowe from the Ministry of Health of Ontario. Funding for the Canadian Pediatric Kidney Disease Research Centre was provided by the Foundation of the Children's Hospital of Eastern Ontario. ",

year = "1998",

doi = "10.1016/S0022-3476(98)70303-8",

language = "English (US)",

volume = "132",

pages = "777--782",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Mosby Inc.",

number = "5",

}

TY - JOUR

T1 - Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection

T2 - Results of a Canadian collaboratlve study

AU - Rowe, P. C.

AU - Orrbine, E.

AU - Lior, H.

AU - Wells, G. A.

AU - Yetisir, E.

AU - Clulow, M.

AU - McLaine, P. N.

AU - Carter, J.

AU - Lirenman, D.

AU - Anderson, J.

AU - Robson, L.

AU - Trevenen, C.

AU - Cadrain, G.

AU - Miller-Hughes, D.

AU - Henning, N.

AU - Anand, C.

AU - Gordon, R.

AU - Cumming, J.

AU - Harley, F.

AU - Kibsey, P.

AU - Rennie, R.

AU - Pearce, P.

AU - McClellan, D.

AU - Hasinoff, D.

AU - Albritton, W. L.

AU - Richter, M.

AU - Tabor, H.

AU - Lovgren, M.

AU - Kasian, G.

AU - Scott, S.

AU - Andreychuk, B.

AU - Bingham, M.

AU - Currie, L.

AU - Homes, B.

AU - Thomas, E.

AU - McNaughton, M.

AU - Ogborn, M.

AU - Grimm, P.

AU - Hoaban, D.

AU - Walker, R.

AU - Sareen, S.

AU - Hammond, G.

AU - Williams, T.

AU - Winther, W.

AU - Clark, W.

AU - Lannigan, R.

AU - Manarin, K.

AU - Parbtani, A.

AU - Hurley, R. M.

AU - Matsell, D. G.

AU - Devuono, T.

AU - Loft, J.

AU - Fase, J.

AU - Reid, A.

AU - Steele, B.

AU - Smaill, F.

AU - Jones, C.

AU - Jones, L. F.

AU - Karmali, M.

AU - Balfe, J. W.

AU - Eddy, A.

AU - Geary, D.

AU - Harvey, E.

AU - Hebert, D.

AU - Skorecki, K.

AU - Winkler, M.

AU - Lapp, V.

AU - Cox, S.

AU - Alexander, D.

AU - Delisle, G.

AU - Toffelmire, E.

AU - Tomalty, L.

AU - Kilbred, B.

AU - Morrin, P.

AU - Singer, M.

AU - Peterson, Y.

AU - Chan, F.

AU - Wolfish, N.

AU - MacKenzie, A.

AU - Fuite, L.

AU - Hyde, L.

AU - Ng, B.

AU - DeJesus, C.

AU - Le Saux, N.

AU - Stewart, M.

AU - Ellis, E.

AU - Goodver, K.

AU - Trifiro, S.

AU - Drummond, K.

AU - Bell, L.

AU - Laforte, D.

AU - O'Reagan, S.

AU - Robitaille, P.

AU - Mongeau, J. G.

AU - Clermont, J.

AU - Letourneau, J.

AU - Douville, G.

AU - Brown, M.

AU - Cote, L.

N1 - Funding Information: Supported by a grant (6606-4519-54) from the National Health Research and Development Program, Health and Welfare Canada and in part by a Career Scientist Award to Dr. Rowe from the Ministry of Health of Ontario. Funding for the Canadian Pediatric Kidney Disease Research Centre was provided by the Foundation of the Children's Hospital of Eastern Ontario.

PY - 1998

Y1 - 1998

N2 - Objectives: The objectives of this study were to better estimate the age-specific risks of hemolytic uremic syndrome (HUS) and hemolytic anemia after Escherichia coli O157:H7 infection among a representative cohort of both referred and nonreferred children with documented illness from the province of Alberta and to compare this with the rates in children evaluated at referral centers in the rest of Canada. Study design: Children with H US or E. coli O157:H7 gastroenteritis were eligible if they were <15 years of age. Hemoglobin, blood smear, urinalysis, and serum creatinine were obtained 8 to 10 days after the onset of diarrhea to ascertain for hemolysis, anemia, thrombocytopenia, and renal injury. Subjects were monitored for 1 month. Results: From June 1991 to March 1994, HUS was diagnosed in 205 children. Of these 77% had evidence or E. coli O157:H7 infection. A further 582 children had E. coli O157:H7 gastroenteritis, of whom 18 had hemolytic anemia. The risk of HUS after E. coli O157:H7 infection in Alberta was 8.1% (95% confidence interval, 5.3 to 11.6) compared with 31.4% in referral centers in the rest of Canada. In Alberta the highest age-specific risk f HUS/hemolytic anemia was 12.9% in those <5 years of age. Conclusions: These data will help guide clinical care and provide a basis for estimating the sample sizes required in future treatment trials for the secondary prevention of 11 US.

AB - Objectives: The objectives of this study were to better estimate the age-specific risks of hemolytic uremic syndrome (HUS) and hemolytic anemia after Escherichia coli O157:H7 infection among a representative cohort of both referred and nonreferred children with documented illness from the province of Alberta and to compare this with the rates in children evaluated at referral centers in the rest of Canada. Study design: Children with H US or E. coli O157:H7 gastroenteritis were eligible if they were <15 years of age. Hemoglobin, blood smear, urinalysis, and serum creatinine were obtained 8 to 10 days after the onset of diarrhea to ascertain for hemolysis, anemia, thrombocytopenia, and renal injury. Subjects were monitored for 1 month. Results: From June 1991 to March 1994, HUS was diagnosed in 205 children. Of these 77% had evidence or E. coli O157:H7 infection. A further 582 children had E. coli O157:H7 gastroenteritis, of whom 18 had hemolytic anemia. The risk of HUS after E. coli O157:H7 infection in Alberta was 8.1% (95% confidence interval, 5.3 to 11.6) compared with 31.4% in referral centers in the rest of Canada. In Alberta the highest age-specific risk f HUS/hemolytic anemia was 12.9% in those <5 years of age. Conclusions: These data will help guide clinical care and provide a basis for estimating the sample sizes required in future treatment trials for the secondary prevention of 11 US.

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UR - http://www.scopus.com/inward/citedby.url?scp=17744411591&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(98)70303-8

DO - 10.1016/S0022-3476(98)70303-8

M3 - Article

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AN - SCOPUS:17744411591

SN - 0022-3476

VL - 132

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JO - Journal of Pediatrics

JF - Journal of Pediatrics

IS - 5

ER -

Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: Results of a Canadian collaboratlve study

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