TY - JOUR
T1 - Risk of coronary artery disease in patients with idiopathic inflammatory myopathies
T2 - A systematic review and meta-analysis of observational studies
AU - Ungprasert, Patompong
AU - Suksaranjit, Promporn
AU - Spanuchart, Ittikorn
AU - Leeaphorn, Napat
AU - Permpalung, Nitipong
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/8
Y1 - 2014/8
N2 - Objectives: To investigate the risk of coronary artery disease in patients with idiopathic inflammatory myopathies (IIM). Methods: We conducted a systematic review and meta-analysis of observational studies that reported odds ratios, relative risks, hazard ratios, or standardized incidence ratios comparing the risk of coronary artery disease in patients with IIM versus non-IIM participants. We searched published studies indexed in MEDLINE, EMBASE, and the Cochrane database from inception to December 2013 using the terms "coronary artery disease" OR "coronary heart disease" OR "myocardial infarction" OR "atherosclerosis" combined with the terms "dermatomyositis" OR "polymyositis" OR "Idiopathic inflammatory myopathy." Pooled risk ratio and 95% confidence interval were calculated using a random-effect, generic inverse variance method. Result: Overall, four studies were identified and included for data analysis. The pooled risk ratio of CAD in patients with IIM was 2.24 (95% CI: 1.02-4.92). The statistical heterogeneity of this meta-analysis was high with an I2 of 97%. Conclusion: Our study demonstrated a statistically significant increased risk of CAD among patients with IIM.
AB - Objectives: To investigate the risk of coronary artery disease in patients with idiopathic inflammatory myopathies (IIM). Methods: We conducted a systematic review and meta-analysis of observational studies that reported odds ratios, relative risks, hazard ratios, or standardized incidence ratios comparing the risk of coronary artery disease in patients with IIM versus non-IIM participants. We searched published studies indexed in MEDLINE, EMBASE, and the Cochrane database from inception to December 2013 using the terms "coronary artery disease" OR "coronary heart disease" OR "myocardial infarction" OR "atherosclerosis" combined with the terms "dermatomyositis" OR "polymyositis" OR "Idiopathic inflammatory myopathy." Pooled risk ratio and 95% confidence interval were calculated using a random-effect, generic inverse variance method. Result: Overall, four studies were identified and included for data analysis. The pooled risk ratio of CAD in patients with IIM was 2.24 (95% CI: 1.02-4.92). The statistical heterogeneity of this meta-analysis was high with an I2 of 97%. Conclusion: Our study demonstrated a statistically significant increased risk of CAD among patients with IIM.
KW - Atherosclerosis
KW - Coronary artery disease
KW - Dermatomyositis
KW - Idiopathic inflammatory myopathies
KW - Meta-analysis
KW - Polymyositis
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U2 - 10.1016/j.semarthrit.2014.03.004
DO - 10.1016/j.semarthrit.2014.03.004
M3 - Article
C2 - 24684974
AN - SCOPUS:84905216800
SN - 0049-0172
VL - 44
SP - 63
EP - 67
JO - Seminars in Arthritis and Rheumatism
JF - Seminars in Arthritis and Rheumatism
IS - 1
ER -