Risk of colorectal cancer in juvenile polyposis

Lodewijk A.A. Brosens; Arnout Van Hattem; Linda M. Hylind; Christine Iacobuzio-Donahue; Katharine E. Romans; Jennifer Axilbund; Marcia Cruz-Correa; Anne C. Tersmette; G. Johan A. Offerhaus; Francis M. Giardiello

doi:10.1136/gut.2006.116913

Risk of colorectal cancer in juvenile polyposis

Lodewijk A.A. Brosens, Arnout Van Hattem, Linda M. Hylind, Christine Iacobuzio-Donahue, Katharine E. Romans, Jennifer Axilbund, Marcia Cruz-Correa, Anne C. Tersmette, G. Johan A. Offerhaus, Francis M. Giardiello

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Juvenile polyposis (JP) is an autosomal-dominant syndrome characterised by the development of hamartomatous gastrointestinal polyps and is associated with colorectal cancer. However, the relative and absolute risk of colorectal malignancy in these patients is not known. Methods: The incidence rates of colorectal cancer in patients with JP were compared with that of the general population through person-year analysis with adjustment for demographics. Results: In patients with JP, the RR (95% CI) of colorectal cancer was 34.0 (14.4 to 65.7). Similar risks were noted in both males (30.0, 9.6 to 68.6) and females (43.7, 8.8 to 125). The cumulative life-time risk for colorectal cancer was 38.7%. The mean (SD) age of diagnosis of colorectal cancer was 43.9 (10.4) years. Other gastrointestinal malignancies were not noted in this cohort. Conclusion: Patients with JP have a markedly increased RR and absolute risk for colorectal cancer and require vigilant colorectal surveillance starting at young age. A low threshold for recommending surgery with consideration for removal of the entire colorectum seems warranted.

Original language	English (US)
Pages (from-to)	965-967
Number of pages	3
Journal	Gut
Volume	56
Issue number	7
DOIs	https://doi.org/10.1136/gut.2006.116913
State	Published - Jul 2007

ASJC Scopus subject areas

Gastroenterology

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Risk of colorectal cancer in juvenile polyposis. / Brosens, Lodewijk A.A.; Van Hattem, Arnout; Hylind, Linda M.; Iacobuzio-Donahue, Christine; Romans, Katharine E.; Axilbund, Jennifer; Cruz-Correa, Marcia; Tersmette, Anne C.; Offerhaus, G. Johan A.; Giardiello, Francis M.

In: Gut, Vol. 56, No. 7, 07.2007, p. 965-967.

Research output: Contribution to journal › Article › peer-review

@article{1de03d6cd45b40568bc2c66246bab443,

title = "Risk of colorectal cancer in juvenile polyposis",

abstract = "Background: Juvenile polyposis (JP) is an autosomal-dominant syndrome characterised by the development of hamartomatous gastrointestinal polyps and is associated with colorectal cancer. However, the relative and absolute risk of colorectal malignancy in these patients is not known. Methods: The incidence rates of colorectal cancer in patients with JP were compared with that of the general population through person-year analysis with adjustment for demographics. Results: In patients with JP, the RR (95% CI) of colorectal cancer was 34.0 (14.4 to 65.7). Similar risks were noted in both males (30.0, 9.6 to 68.6) and females (43.7, 8.8 to 125). The cumulative life-time risk for colorectal cancer was 38.7%. The mean (SD) age of diagnosis of colorectal cancer was 43.9 (10.4) years. Other gastrointestinal malignancies were not noted in this cohort. Conclusion: Patients with JP have a markedly increased RR and absolute risk for colorectal cancer and require vigilant colorectal surveillance starting at young age. A low threshold for recommending surgery with consideration for removal of the entire colorectum seems warranted.",

author = "Brosens, {Lodewijk A.A.} and {Van Hattem}, Arnout and Hylind, {Linda M.} and Christine Iacobuzio-Donahue and Romans, {Katharine E.} and Jennifer Axilbund and Marcia Cruz-Correa and Tersmette, {Anne C.} and Offerhaus, {G. Johan A.} and Giardiello, {Francis M.}",

year = "2007",

month = jul,

doi = "10.1136/gut.2006.116913",

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T1 - Risk of colorectal cancer in juvenile polyposis

AU - Brosens, Lodewijk A.A.

AU - Van Hattem, Arnout

AU - Hylind, Linda M.

AU - Iacobuzio-Donahue, Christine

AU - Romans, Katharine E.

AU - Axilbund, Jennifer

AU - Cruz-Correa, Marcia

AU - Tersmette, Anne C.

AU - Offerhaus, G. Johan A.

AU - Giardiello, Francis M.

PY - 2007/7

Y1 - 2007/7

N2 - Background: Juvenile polyposis (JP) is an autosomal-dominant syndrome characterised by the development of hamartomatous gastrointestinal polyps and is associated with colorectal cancer. However, the relative and absolute risk of colorectal malignancy in these patients is not known. Methods: The incidence rates of colorectal cancer in patients with JP were compared with that of the general population through person-year analysis with adjustment for demographics. Results: In patients with JP, the RR (95% CI) of colorectal cancer was 34.0 (14.4 to 65.7). Similar risks were noted in both males (30.0, 9.6 to 68.6) and females (43.7, 8.8 to 125). The cumulative life-time risk for colorectal cancer was 38.7%. The mean (SD) age of diagnosis of colorectal cancer was 43.9 (10.4) years. Other gastrointestinal malignancies were not noted in this cohort. Conclusion: Patients with JP have a markedly increased RR and absolute risk for colorectal cancer and require vigilant colorectal surveillance starting at young age. A low threshold for recommending surgery with consideration for removal of the entire colorectum seems warranted.

AB - Background: Juvenile polyposis (JP) is an autosomal-dominant syndrome characterised by the development of hamartomatous gastrointestinal polyps and is associated with colorectal cancer. However, the relative and absolute risk of colorectal malignancy in these patients is not known. Methods: The incidence rates of colorectal cancer in patients with JP were compared with that of the general population through person-year analysis with adjustment for demographics. Results: In patients with JP, the RR (95% CI) of colorectal cancer was 34.0 (14.4 to 65.7). Similar risks were noted in both males (30.0, 9.6 to 68.6) and females (43.7, 8.8 to 125). The cumulative life-time risk for colorectal cancer was 38.7%. The mean (SD) age of diagnosis of colorectal cancer was 43.9 (10.4) years. Other gastrointestinal malignancies were not noted in this cohort. Conclusion: Patients with JP have a markedly increased RR and absolute risk for colorectal cancer and require vigilant colorectal surveillance starting at young age. A low threshold for recommending surgery with consideration for removal of the entire colorectum seems warranted.

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