TY - JOUR
T1 - Risk of Colorectal and Other Cancers in Patients With Serrated Polyposis
AU - Edelstein, Daniel L.
AU - Cruz-Correa, Marcia
AU - Soto-Salgado, Marievelisse
AU - Axilbund, Jennifer E.
AU - Hylind, Linda M.
AU - Romans, Katharine
AU - Blair, Cherie
AU - Wiley, Elizabeth
AU - Tersmette, Anne C.
AU - Offerhaus, Johan A.
AU - Giardiello, Francis M.
N1 - Publisher Copyright:
© 2015 AGA Institute.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Patients with serrated polyposis develop multiple colorectal hyperplastic and/or serrated sessile adenomas/polyps. We investigated the risk of colorectal and other cancers by analyzing data from 64 patients with serrated polyposis (mean age at diagnosis, 54 y; 41% men; 92% white) listed in the Johns Hopkins Polyposis Registry. Medical, endoscopic, and histopathology reports were evaluated. Six patients (9.4%) had a history of colorectal cancer, diagnosed at a mean age of 56 years; 6 additional patients (9.4%) had at least 1 advanced colorectal adenoma. Extracolonic cancers were found in 16% of the study population. The standard incidence ratio for colorectal cancer in patients with serrated polyposis was 18.72 (95% confidence interval, 6.87-40.74) and for extracolonic cancer was 31.20 (95% confidence interval, 14.96-57.37), compared with the Surveillance, Epidemiology, and End Results population. Patients with serrated polyposis therefore have a high risk for colorectal cancer and require vigilant colorectal surveillance, starting at the time of diagnosis of serrated polyposis. The risk of extracolonic cancer also appears to be increased, but this requires further evaluation.
AB - Patients with serrated polyposis develop multiple colorectal hyperplastic and/or serrated sessile adenomas/polyps. We investigated the risk of colorectal and other cancers by analyzing data from 64 patients with serrated polyposis (mean age at diagnosis, 54 y; 41% men; 92% white) listed in the Johns Hopkins Polyposis Registry. Medical, endoscopic, and histopathology reports were evaluated. Six patients (9.4%) had a history of colorectal cancer, diagnosed at a mean age of 56 years; 6 additional patients (9.4%) had at least 1 advanced colorectal adenoma. Extracolonic cancers were found in 16% of the study population. The standard incidence ratio for colorectal cancer in patients with serrated polyposis was 18.72 (95% confidence interval, 6.87-40.74) and for extracolonic cancer was 31.20 (95% confidence interval, 14.96-57.37), compared with the Surveillance, Epidemiology, and End Results population. Patients with serrated polyposis therefore have a high risk for colorectal cancer and require vigilant colorectal surveillance, starting at the time of diagnosis of serrated polyposis. The risk of extracolonic cancer also appears to be increased, but this requires further evaluation.
KW - Colon Cancer
KW - Hyperplastic Polyps
KW - Premalignant
KW - Sessile Polyps
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U2 - 10.1016/j.cgh.2015.02.003
DO - 10.1016/j.cgh.2015.02.003
M3 - Article
C2 - 25681317
AN - SCOPUS:84939574779
SN - 1542-3565
VL - 13
SP - 1697
EP - 1699
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 9
ER -