TY - JOUR
T1 - Risk of chronic obstructive pulmonary disease in healthy individuals with high C-reactive protein levels by smoking status
T2 - A population-based cohort study in Korea
AU - Lim, Seong Yong
AU - Zhao, Di
AU - Guallar, Eliseo
AU - Chang, Yoosoo
AU - Ryu, Seungho
AU - Cho, Juhee
AU - Shim, Jung Yeon
N1 - Publisher Copyright:
© 2019 Lim et al.
PY - 2019
Y1 - 2019
N2 - Purpose: Chronic obstructive pulmonary disease (COPD) is associated with systemic inflammation. We investigated whether elevated baseline serum C-reactive protein (CRP) levels in healthy individuals are associated with the risk of incident COPD by smoking status. Patients and methods: This was a cohort study of 63,260 adult men and women who were older than 40 years, free of COPD at baseline, and underwent health screening from 2002 to 2016 with at least one follow-up visit through December 2016. We investigated the association between baseline high-sensitivity CRP (hsCRP) levels and incident COPD by smoking status, using flexible parametric proportional hazards models and pooled logistic regression analyses. Results: The multivariable-adjusted hazard ratio (95% confidence interval) comparing participants in the 90th to those in the 10th percentile of hsCRP was 1.19 (1.08, 1.31). The corresponding hazard ratio in never, former, and current smokers were 1.07 (0.89, 1.29), 1.22 (1.05, 1.42), and 1.22 (1.05, 1.41), respectively. The association between hsCRP levels and incident COPD had a similar dose–response pattern in former and current smokers, but not in never smokers. Conclusion: Higher baseline hsCRP is associated with an increased risk to develop COPD in ever smokers but not in never smokers.
AB - Purpose: Chronic obstructive pulmonary disease (COPD) is associated with systemic inflammation. We investigated whether elevated baseline serum C-reactive protein (CRP) levels in healthy individuals are associated with the risk of incident COPD by smoking status. Patients and methods: This was a cohort study of 63,260 adult men and women who were older than 40 years, free of COPD at baseline, and underwent health screening from 2002 to 2016 with at least one follow-up visit through December 2016. We investigated the association between baseline high-sensitivity CRP (hsCRP) levels and incident COPD by smoking status, using flexible parametric proportional hazards models and pooled logistic regression analyses. Results: The multivariable-adjusted hazard ratio (95% confidence interval) comparing participants in the 90th to those in the 10th percentile of hsCRP was 1.19 (1.08, 1.31). The corresponding hazard ratio in never, former, and current smokers were 1.07 (0.89, 1.29), 1.22 (1.05, 1.42), and 1.22 (1.05, 1.41), respectively. The association between hsCRP levels and incident COPD had a similar dose–response pattern in former and current smokers, but not in never smokers. Conclusion: Higher baseline hsCRP is associated with an increased risk to develop COPD in ever smokers but not in never smokers.
KW - C-reactive protein
KW - COPD
KW - Cohort studies
KW - Smokers
KW - Systemic inflammation
UR - http://www.scopus.com/inward/record.url?scp=85072745849&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072745849&partnerID=8YFLogxK
U2 - 10.2147/COPD.S213665
DO - 10.2147/COPD.S213665
M3 - Article
C2 - 31564851
AN - SCOPUS:85072745849
SN - 1176-9106
VL - 14
SP - 2037
EP - 2046
JO - International Journal of COPD
JF - International Journal of COPD
ER -