Risk of cataract in persons with cytomegalovirus retinitis and the acquired immune deficiency syndrome

John H. Kempen, Elizabeth Sugar, Alice T. Lyon, Richard Alan Lewis, Douglas Jabs, Murk Hein Heinemann, James P. Dunn

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate cataract risk in eyes of patients with AIDS and cytomegalovirus (CMV) retinitis and to identify risk factors. Design: Prospective cohort study. Participants: Patients with AIDS and CMV retinitis. Methods: Patients 13 years of age and older were enrolled between 1998 and 2008. Demographic and clinical characteristics, slit-lamp biomicroscopy findings, and dilated ophthalmoscopy results were documented at quarterly visits. Cataract status was determined at the initial visit (prevalence) and at follow-up visits (incidence). Main Outcome Measures: For cataract, a high grade of lens opacity by biomicroscopy to which best-corrected visual acuity worse than 20/40 was attributed. Eyes that had undergone cataract surgery before enrollment or between visits also were counted as having cataract. Results: Seven hundred twenty-nine eyes of 489 patients diagnosed with CMV retinitis were evaluated. Higher prevalence was observed for patients with bilateral versus unilateral CMV retinitis (adjusted odds ratio [aOR], 2.74; 95% confidence interval [CI], 1.76-4.26) and, among unilateral CMV retinitis cases, for eyes with retinitis versus without retinitis (15% vs. 1.4%; P

Original languageEnglish (US)
Pages (from-to)2343-2350
Number of pages8
JournalOphthalmology
Volume119
Issue number11
DOIs
StatePublished - Nov 2012

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Cytomegalovirus Retinitis
Cataract
Acquired Immunodeficiency Syndrome
Retinitis
Ophthalmoscopy
Visual Acuity
Cohort Studies
Odds Ratio
Demography
Outcome Assessment (Health Care)
Prospective Studies
Confidence Intervals
Incidence

ASJC Scopus subject areas

  • Ophthalmology

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Risk of cataract in persons with cytomegalovirus retinitis and the acquired immune deficiency syndrome. / Kempen, John H.; Sugar, Elizabeth; Lyon, Alice T.; Lewis, Richard Alan; Jabs, Douglas; Heinemann, Murk Hein; Dunn, James P.

In: Ophthalmology, Vol. 119, No. 11, 11.2012, p. 2343-2350.

Research output: Contribution to journalArticle

Kempen, John H. ; Sugar, Elizabeth ; Lyon, Alice T. ; Lewis, Richard Alan ; Jabs, Douglas ; Heinemann, Murk Hein ; Dunn, James P. / Risk of cataract in persons with cytomegalovirus retinitis and the acquired immune deficiency syndrome. In: Ophthalmology. 2012 ; Vol. 119, No. 11. pp. 2343-2350.
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