Abstract
Woman with BRCA-1 or BRCA-2 mutations have a significantly increased risk for breast cancer. While genetic testing can provide valuable information concerning this increased risk and the proposed benefit of risk-reducing interventions, the absolute breast cancer risk conferred by BRCA-1 and BRCA-2 mutations remains to be fully determined. The American Society of Clinical Oncology (ASCO) guidelines indicate that testing should be considered in women whose mutation probability is greater than 10%. None of the currently available approaches for determining BRCA gene mutation probability are 100% accurate. The computer program BRCAPRO is a useful adjunct for estimating these probabilities, but limitations inherent in mathematical models make it essential that genetic counselors are involved in decisions to perform genetic testing.
Original language | English (US) |
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Pages (from-to) | S10-S12 |
Journal | Breast Journal |
Volume | 10 |
Issue number | 1 SUPPL. |
DOIs | |
State | Published - 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Internal Medicine
- Surgery
- Oncology