Risk for Perinatal HIV-1 Transmission According to Maternal Immunologic, Virologic, and Placental Factors

Michael E St Louis, Munkolenkole Kamenga, Christopher Brown, Ann Marie Nelson, Tarande Manzila, Veronique Batter, Frieda Behets, Uwa Kabagabo, Robert W. Ryder, Margaret Oxtoby, Thomas C Quinn, William L. Heyward

Research output: Contribution to journalArticle

Abstract

Objective.—To evaluate how maternal and obstetric factors interact to influence mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission. Design.—Prospective, observational cohort study of children born to HIV-infected women to determine child’s HIV infection status. The analysis then compared peripartum maternal, placental, and obstetric variables between HIV-1 transmitter and nontransmitter women. Setting.—Two large maternity wards in Kinshasa, Zaire. Participants.—Consecutive sample of 324 HIV-1—infected women at delivery, with 254 HIV-seronegative women followed up as control subjects. Principal Outcome Measures.—HIV infection status of children, to classify each woman as an HIV-1 transmitter or nontransmitter. Results.—The highest transmission risk (TR) was associated with maternal p24 antigenemia (TR, 71%; relative risk [RR], 3.0; 95% confidence interval [CI], 1.7 to 5.2) and maternal CD8+ lymphocyte counts of at least 1.80×109/L (1800/μL) (TR, 50%; RR, 2.2; 95% CI, 1.2 to 4.2). Among women with CD8+ lymphocyte counts of less than 1.80×109/L, CD4+ lymphocyte counts of less than 0.60×109/L were a risk factor (TR, 29%; RR, 2.2; 95% CI, 1.2 to 4.2). In women with neither high CD8+ nor low CD4+ lymphocyte counts, placental membrane inflammation was associated with perinatal transmission (TR, 40%; RR, 4.2; 95% CI, 1.3 to 13.7). In women with neither p24 antigenemia, high CD8+ or low CD4+ lymphocyte counts, nor placental membrane inflammation, the transmission risk was only 7%. Additional correlates of transmission included maternal anemia and fever, but not maternal sexually transmitted diseases. Conclusions.—Identifiable subgroups of HIV-1—infected women based on maternal and placental characteristics had between a 7% and 71% risk of perinatal HIV-1 transmission. Not only the overall rate of transmission but the impact of different risk factors for transmission appear to vary over the course of HIV infection.

Original languageEnglish (US)
Pages (from-to)2853-2859
Number of pages7
JournalJournal of the American Medical Association
Volume269
Issue number22
DOIs
Publication statusPublished - Jun 9 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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Louis, M. E. S., Kamenga, M., Brown, C., Nelson, A. M., Manzila, T., Batter, V., ... Heyward, W. L. (1993). Risk for Perinatal HIV-1 Transmission According to Maternal Immunologic, Virologic, and Placental Factors. Journal of the American Medical Association, 269(22), 2853-2859. https://doi.org/10.1001/jama.1993.03500220039023