Abstract
Objectives: In western countries, 7% to 10% of patients with pancreatic cancer (PC) have a familial predisposition to their disease. The aim of this study was to determine the familial susceptibility to PC in Japan. Methods: Five hundred seventy-seven patients with PC and 577 age- and gender-matched controls were analyzed for cancer history in their first-degree relative(s) (FDRs) and demographic factors. Results: The patients with PC were more likely to have an FDR with PC (6.9%) than the controls (2.9%; odds ratio [OR], 2.5; P = 0.02). Three patients (0.5%), but none of the controls, had a family history of PC in multiple FDRs. Smoking, especially current smoking (OR, 1.5; P = 0.005), and diabetes mellitus (OR: 1.7, P = 0.001) were also associated with PC. The odds increased up to 10-fold if the patients were positive for these 3 factors. The patients with familial PC were more likely to be current smokers (40%) and to have diabetes mellitus (32.5%) than the sporadic cases (30.1% and 20.1%; OR, 1.6 and 1.9). Conclusions: A family history of PC is a risk of PC in Japan (6.9%) as is a personal history of diabetes and smoking. It is prudent to inform the kindred of patients with familiar PC of the risk of smoking and to follow carefully if they develop diabetes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 974-978 |
| Number of pages | 5 |
| Journal | Pancreas |
| Volume | 40 |
| Issue number | 6 |
| DOIs | |
| State | Published - Aug 2011 |
Fingerprint
Keywords
- early detection
- familial pancreatic cancer
- family history
- Japan
- pancreatic cancer
- risk factor
ASJC Scopus subject areas
- Hepatology
- Internal Medicine
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Risk factors of familial pancreatic cancer in Japan : Current smoking and recent onset of diabetes. / Matsubayashi, Hiroyuki; Maeda, Atsuyuki; Kanemoto, Hideyuki; Uesaka, Katsuhiko; Yamazaki, Kentaro; Hironaka, Shuichi; Miyagi, Yuji; Ikehara, Hisatomo; Ono, Hiroyuki; Klein, Alison; Goggins, Michael S.
In: Pancreas, Vol. 40, No. 6, 08.2011, p. 974-978.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk factors of familial pancreatic cancer in Japan
T2 - Current smoking and recent onset of diabetes
AU - Matsubayashi, Hiroyuki
AU - Maeda, Atsuyuki
AU - Kanemoto, Hideyuki
AU - Uesaka, Katsuhiko
AU - Yamazaki, Kentaro
AU - Hironaka, Shuichi
AU - Miyagi, Yuji
AU - Ikehara, Hisatomo
AU - Ono, Hiroyuki
AU - Klein, Alison
AU - Goggins, Michael S
PY - 2011/8
Y1 - 2011/8
N2 - Objectives: In western countries, 7% to 10% of patients with pancreatic cancer (PC) have a familial predisposition to their disease. The aim of this study was to determine the familial susceptibility to PC in Japan. Methods: Five hundred seventy-seven patients with PC and 577 age- and gender-matched controls were analyzed for cancer history in their first-degree relative(s) (FDRs) and demographic factors. Results: The patients with PC were more likely to have an FDR with PC (6.9%) than the controls (2.9%; odds ratio [OR], 2.5; P = 0.02). Three patients (0.5%), but none of the controls, had a family history of PC in multiple FDRs. Smoking, especially current smoking (OR, 1.5; P = 0.005), and diabetes mellitus (OR: 1.7, P = 0.001) were also associated with PC. The odds increased up to 10-fold if the patients were positive for these 3 factors. The patients with familial PC were more likely to be current smokers (40%) and to have diabetes mellitus (32.5%) than the sporadic cases (30.1% and 20.1%; OR, 1.6 and 1.9). Conclusions: A family history of PC is a risk of PC in Japan (6.9%) as is a personal history of diabetes and smoking. It is prudent to inform the kindred of patients with familiar PC of the risk of smoking and to follow carefully if they develop diabetes.
AB - Objectives: In western countries, 7% to 10% of patients with pancreatic cancer (PC) have a familial predisposition to their disease. The aim of this study was to determine the familial susceptibility to PC in Japan. Methods: Five hundred seventy-seven patients with PC and 577 age- and gender-matched controls were analyzed for cancer history in their first-degree relative(s) (FDRs) and demographic factors. Results: The patients with PC were more likely to have an FDR with PC (6.9%) than the controls (2.9%; odds ratio [OR], 2.5; P = 0.02). Three patients (0.5%), but none of the controls, had a family history of PC in multiple FDRs. Smoking, especially current smoking (OR, 1.5; P = 0.005), and diabetes mellitus (OR: 1.7, P = 0.001) were also associated with PC. The odds increased up to 10-fold if the patients were positive for these 3 factors. The patients with familial PC were more likely to be current smokers (40%) and to have diabetes mellitus (32.5%) than the sporadic cases (30.1% and 20.1%; OR, 1.6 and 1.9). Conclusions: A family history of PC is a risk of PC in Japan (6.9%) as is a personal history of diabetes and smoking. It is prudent to inform the kindred of patients with familiar PC of the risk of smoking and to follow carefully if they develop diabetes.
KW - early detection
KW - familial pancreatic cancer
KW - family history
KW - Japan
KW - pancreatic cancer
KW - risk factor
UR - http://www.scopus.com/inward/record.url?scp=80051545326&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051545326&partnerID=8YFLogxK
U2 - 10.1097/MPA.0b013e3182156e1b
DO - 10.1097/MPA.0b013e3182156e1b
M3 - Article
C2 - 21487321
AN - SCOPUS:80051545326
VL - 40
SP - 974
EP - 978
JO - Pancreas
JF - Pancreas
SN - 0885-3177
IS - 6
ER -