Risk factors of familial pancreatic cancer in Japan: Current smoking and recent onset of diabetes

Hiroyuki Matsubayashi, Atsuyuki Maeda, Hideyuki Kanemoto, Katsuhiko Uesaka, Kentaro Yamazaki, Shuichi Hironaka, Yuji Miyagi, Hisatomo Ikehara, Hiroyuki Ono, Alison Klein, Michael S Goggins

Research output: Contribution to journalArticle

Abstract

Objectives: In western countries, 7% to 10% of patients with pancreatic cancer (PC) have a familial predisposition to their disease. The aim of this study was to determine the familial susceptibility to PC in Japan. Methods: Five hundred seventy-seven patients with PC and 577 age- and gender-matched controls were analyzed for cancer history in their first-degree relative(s) (FDRs) and demographic factors. Results: The patients with PC were more likely to have an FDR with PC (6.9%) than the controls (2.9%; odds ratio [OR], 2.5; P = 0.02). Three patients (0.5%), but none of the controls, had a family history of PC in multiple FDRs. Smoking, especially current smoking (OR, 1.5; P = 0.005), and diabetes mellitus (OR: 1.7, P = 0.001) were also associated with PC. The odds increased up to 10-fold if the patients were positive for these 3 factors. The patients with familial PC were more likely to be current smokers (40%) and to have diabetes mellitus (32.5%) than the sporadic cases (30.1% and 20.1%; OR, 1.6 and 1.9). Conclusions: A family history of PC is a risk of PC in Japan (6.9%) as is a personal history of diabetes and smoking. It is prudent to inform the kindred of patients with familiar PC of the risk of smoking and to follow carefully if they develop diabetes.

Original languageEnglish (US)
Pages (from-to)974-978
Number of pages5
JournalPancreas
Volume40
Issue number6
DOIs
StatePublished - Aug 2011

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Pancreatic Neoplasms
Japan
Smoking
Odds Ratio
Diabetes Mellitus
Demography

Keywords

  • early detection
  • familial pancreatic cancer
  • family history
  • Japan
  • pancreatic cancer
  • risk factor

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Risk factors of familial pancreatic cancer in Japan : Current smoking and recent onset of diabetes. / Matsubayashi, Hiroyuki; Maeda, Atsuyuki; Kanemoto, Hideyuki; Uesaka, Katsuhiko; Yamazaki, Kentaro; Hironaka, Shuichi; Miyagi, Yuji; Ikehara, Hisatomo; Ono, Hiroyuki; Klein, Alison; Goggins, Michael S.

In: Pancreas, Vol. 40, No. 6, 08.2011, p. 974-978.

Research output: Contribution to journalArticle

Matsubayashi, H, Maeda, A, Kanemoto, H, Uesaka, K, Yamazaki, K, Hironaka, S, Miyagi, Y, Ikehara, H, Ono, H, Klein, A & Goggins, MS 2011, 'Risk factors of familial pancreatic cancer in Japan: Current smoking and recent onset of diabetes', Pancreas, vol. 40, no. 6, pp. 974-978. https://doi.org/10.1097/MPA.0b013e3182156e1b
Matsubayashi H, Maeda A, Kanemoto H, Uesaka K, Yamazaki K, Hironaka S et al. Risk factors of familial pancreatic cancer in Japan: Current smoking and recent onset of diabetes. Pancreas. 2011 Aug;40(6):974-978. https://doi.org/10.1097/MPA.0b013e3182156e1b
Matsubayashi, Hiroyuki ; Maeda, Atsuyuki ; Kanemoto, Hideyuki ; Uesaka, Katsuhiko ; Yamazaki, Kentaro ; Hironaka, Shuichi ; Miyagi, Yuji ; Ikehara, Hisatomo ; Ono, Hiroyuki ; Klein, Alison ; Goggins, Michael S. / Risk factors of familial pancreatic cancer in Japan : Current smoking and recent onset of diabetes. In: Pancreas. 2011 ; Vol. 40, No. 6. pp. 974-978.
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abstract = "Objectives: In western countries, 7{\%} to 10{\%} of patients with pancreatic cancer (PC) have a familial predisposition to their disease. The aim of this study was to determine the familial susceptibility to PC in Japan. Methods: Five hundred seventy-seven patients with PC and 577 age- and gender-matched controls were analyzed for cancer history in their first-degree relative(s) (FDRs) and demographic factors. Results: The patients with PC were more likely to have an FDR with PC (6.9{\%}) than the controls (2.9{\%}; odds ratio [OR], 2.5; P = 0.02). Three patients (0.5{\%}), but none of the controls, had a family history of PC in multiple FDRs. Smoking, especially current smoking (OR, 1.5; P = 0.005), and diabetes mellitus (OR: 1.7, P = 0.001) were also associated with PC. The odds increased up to 10-fold if the patients were positive for these 3 factors. The patients with familial PC were more likely to be current smokers (40{\%}) and to have diabetes mellitus (32.5{\%}) than the sporadic cases (30.1{\%} and 20.1{\%}; OR, 1.6 and 1.9). Conclusions: A family history of PC is a risk of PC in Japan (6.9{\%}) as is a personal history of diabetes and smoking. It is prudent to inform the kindred of patients with familiar PC of the risk of smoking and to follow carefully if they develop diabetes.",
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AU - Matsubayashi, Hiroyuki

AU - Maeda, Atsuyuki

AU - Kanemoto, Hideyuki

AU - Uesaka, Katsuhiko

AU - Yamazaki, Kentaro

AU - Hironaka, Shuichi

AU - Miyagi, Yuji

AU - Ikehara, Hisatomo

AU - Ono, Hiroyuki

AU - Klein, Alison

AU - Goggins, Michael S

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N2 - Objectives: In western countries, 7% to 10% of patients with pancreatic cancer (PC) have a familial predisposition to their disease. The aim of this study was to determine the familial susceptibility to PC in Japan. Methods: Five hundred seventy-seven patients with PC and 577 age- and gender-matched controls were analyzed for cancer history in their first-degree relative(s) (FDRs) and demographic factors. Results: The patients with PC were more likely to have an FDR with PC (6.9%) than the controls (2.9%; odds ratio [OR], 2.5; P = 0.02). Three patients (0.5%), but none of the controls, had a family history of PC in multiple FDRs. Smoking, especially current smoking (OR, 1.5; P = 0.005), and diabetes mellitus (OR: 1.7, P = 0.001) were also associated with PC. The odds increased up to 10-fold if the patients were positive for these 3 factors. The patients with familial PC were more likely to be current smokers (40%) and to have diabetes mellitus (32.5%) than the sporadic cases (30.1% and 20.1%; OR, 1.6 and 1.9). Conclusions: A family history of PC is a risk of PC in Japan (6.9%) as is a personal history of diabetes and smoking. It is prudent to inform the kindred of patients with familiar PC of the risk of smoking and to follow carefully if they develop diabetes.

AB - Objectives: In western countries, 7% to 10% of patients with pancreatic cancer (PC) have a familial predisposition to their disease. The aim of this study was to determine the familial susceptibility to PC in Japan. Methods: Five hundred seventy-seven patients with PC and 577 age- and gender-matched controls were analyzed for cancer history in their first-degree relative(s) (FDRs) and demographic factors. Results: The patients with PC were more likely to have an FDR with PC (6.9%) than the controls (2.9%; odds ratio [OR], 2.5; P = 0.02). Three patients (0.5%), but none of the controls, had a family history of PC in multiple FDRs. Smoking, especially current smoking (OR, 1.5; P = 0.005), and diabetes mellitus (OR: 1.7, P = 0.001) were also associated with PC. The odds increased up to 10-fold if the patients were positive for these 3 factors. The patients with familial PC were more likely to be current smokers (40%) and to have diabetes mellitus (32.5%) than the sporadic cases (30.1% and 20.1%; OR, 1.6 and 1.9). Conclusions: A family history of PC is a risk of PC in Japan (6.9%) as is a personal history of diabetes and smoking. It is prudent to inform the kindred of patients with familiar PC of the risk of smoking and to follow carefully if they develop diabetes.

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