Risk factors in interstitial pneumonitis following allogenic bone marrow transplantation

Jose L. Ping Y Torres; Dean S. Bross; Wing chef Lam; Moody D. Wharam; George W. Santos; Stanley E. Order

doi:10.1016/0360-3016(82)90579-X

Risk factors in interstitial pneumonitis following allogenic bone marrow transplantation

Jose L. Ping Y Torres, Dean S. Bross, Wing chef Lam, Moody D. Wharam, George W. Santos, Stanley E. Order

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Total body irradiation is part of the preparatory regimen for allogeneic bone marrow transplantation because of its cytotoxic and immunosuppressive properties. A major toxicity of bone marrow transplantation has been interstitial pneumonitis, which may be, in part, related to the lung irradiation. One hundred and sixty-one consecutive patients receiving allogeneic bone marrow transplantation for leukemia and aplastic anemia at Johns Hopkins Hospital (1968-1979) were retrospectively studied. The present study demonstrated that lung shielding to 600 rad maximum in single dose total body irradiation, fractionation of total body irradiation in comparison to single dose total body irradiation, and absence of graft versus host disease in the leukemia patients, each reduced the risk of interstitial pneumonitis. Total body irradiation significantly reduced the leukemia recurrence rate and/or the failure of remission induction.

Original language	English (US)
Pages (from-to)	1301-1307
Number of pages	7
Journal	International journal of radiation oncology, biology, physics
Volume	8
Issue number	8
DOIs	https://doi.org/10.1016/0360-3016(82)90579-X
State	Published - Aug 1982
Externally published	Yes

Keywords

Aplastic anemia
Interstitial pneumonitis
Leukemia
Total body irradiation

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

Access to Document

10.1016/0360-3016(82)90579-X

Cite this

@article{1cb05ba3f4a14d5e95029718c33d00d0,

title = "Risk factors in interstitial pneumonitis following allogenic bone marrow transplantation",

abstract = "Total body irradiation is part of the preparatory regimen for allogeneic bone marrow transplantation because of its cytotoxic and immunosuppressive properties. A major toxicity of bone marrow transplantation has been interstitial pneumonitis, which may be, in part, related to the lung irradiation. One hundred and sixty-one consecutive patients receiving allogeneic bone marrow transplantation for leukemia and aplastic anemia at Johns Hopkins Hospital (1968-1979) were retrospectively studied. The present study demonstrated that lung shielding to 600 rad maximum in single dose total body irradiation, fractionation of total body irradiation in comparison to single dose total body irradiation, and absence of graft versus host disease in the leukemia patients, each reduced the risk of interstitial pneumonitis. Total body irradiation significantly reduced the leukemia recurrence rate and/or the failure of remission induction.",

keywords = "Aplastic anemia, Interstitial pneumonitis, Leukemia, Total body irradiation",

author = "{Ping Y Torres}, {Jose L.} and Bross, {Dean S.} and Lam, {Wing chef} and Wharam, {Moody D.} and Santos, {George W.} and Order, {Stanley E.}",

note = "Funding Information: Reprint requests to Jose L. Pino y Torres. M.D. Supported by NCI-NIH Grant # CA 15396-07 and CA 06973-18. Presented at the 22nd Annual ASTR Meeting. October 21 -25. 1980. Dallas, Texas. Accepted for publication I4 March 1982.",

year = "1982",

month = aug,

doi = "10.1016/0360-3016(82)90579-X",

language = "English (US)",

volume = "8",

pages = "1301--1307",

journal = "International journal of radiation oncology, biology, physics",

issn = "0360-3016",

publisher = "Elsevier Inc.",

number = "8",

}

TY - JOUR

T1 - Risk factors in interstitial pneumonitis following allogenic bone marrow transplantation

AU - Ping Y Torres, Jose L.

AU - Bross, Dean S.

AU - Lam, Wing chef

AU - Wharam, Moody D.

AU - Santos, George W.

AU - Order, Stanley E.

N1 - Funding Information: Reprint requests to Jose L. Pino y Torres. M.D. Supported by NCI-NIH Grant # CA 15396-07 and CA 06973-18. Presented at the 22nd Annual ASTR Meeting. October 21 -25. 1980. Dallas, Texas. Accepted for publication I4 March 1982.

PY - 1982/8

Y1 - 1982/8

N2 - Total body irradiation is part of the preparatory regimen for allogeneic bone marrow transplantation because of its cytotoxic and immunosuppressive properties. A major toxicity of bone marrow transplantation has been interstitial pneumonitis, which may be, in part, related to the lung irradiation. One hundred and sixty-one consecutive patients receiving allogeneic bone marrow transplantation for leukemia and aplastic anemia at Johns Hopkins Hospital (1968-1979) were retrospectively studied. The present study demonstrated that lung shielding to 600 rad maximum in single dose total body irradiation, fractionation of total body irradiation in comparison to single dose total body irradiation, and absence of graft versus host disease in the leukemia patients, each reduced the risk of interstitial pneumonitis. Total body irradiation significantly reduced the leukemia recurrence rate and/or the failure of remission induction.

AB - Total body irradiation is part of the preparatory regimen for allogeneic bone marrow transplantation because of its cytotoxic and immunosuppressive properties. A major toxicity of bone marrow transplantation has been interstitial pneumonitis, which may be, in part, related to the lung irradiation. One hundred and sixty-one consecutive patients receiving allogeneic bone marrow transplantation for leukemia and aplastic anemia at Johns Hopkins Hospital (1968-1979) were retrospectively studied. The present study demonstrated that lung shielding to 600 rad maximum in single dose total body irradiation, fractionation of total body irradiation in comparison to single dose total body irradiation, and absence of graft versus host disease in the leukemia patients, each reduced the risk of interstitial pneumonitis. Total body irradiation significantly reduced the leukemia recurrence rate and/or the failure of remission induction.

KW - Aplastic anemia

KW - Interstitial pneumonitis

KW - Leukemia

KW - Total body irradiation

UR - http://www.scopus.com/inward/record.url?scp=0019976847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019976847&partnerID=8YFLogxK

U2 - 10.1016/0360-3016(82)90579-X

DO - 10.1016/0360-3016(82)90579-X

M3 - Article

C2 - 6754666

AN - SCOPUS:0019976847

SN - 0360-3016

VL - 8

SP - 1301

EP - 1307

JO - International journal of radiation oncology, biology, physics

JF - International journal of radiation oncology, biology, physics

IS - 8

ER -

Risk factors in interstitial pneumonitis following allogenic bone marrow transplantation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this