Risk Factors for SARS among Persons without Known Contact with SARS Patients, Beijing, China

Jiang Wu, Fujie Xu, Weigong Zhou, Daniel R. Feikin, Chang Ying Lin, Xiong He, Zonghan Zhu, Wannian Liang, Daniel P. Chin, Anne Schuchat

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


Most cases of severe acute respiratory syndrome (SARS) have occurred in close contacts of SARS patients. However, in Beijing, a large proportion of SARS cases occurred in persons without such contact. We conducted a case-control study in Beijing that compared exposures of 94 unlinked, probable SARS patients with those of 281 community-based controls matched for age group and sex. Case-patients were more likely than controls to have chronic medical conditions or to have visited fever clinics (clinics at which possible SARS patients were separated from other patients), eaten outside the home, or taken taxis frequently. The use of masks was strongly protective. Among 31 case-patients for whom convalescent-phase (>21 days) sera were available, 26% had immunoglobulin G to SARS-associated coronavirus. Our finding that clinical SARS was associated with visits to fever clinics supports Beijing's strategy of closing clinics with poor infection-control measures. Our finding that mask use lowered the risk for disease supports the community's use of this strategy.

Original languageEnglish (US)
Pages (from-to)210-216
Number of pages7
JournalEmerging infectious diseases
Issue number2
StatePublished - Feb 2004
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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