TY - JOUR
T1 - Risk factors for post-stem cell transplant sinusitis
AU - Thompson, A. M.
AU - Couch, M.
AU - Zahurak, M. L.
AU - Johnson, C.
AU - Vogelsang, G. B.
PY - 2002
Y1 - 2002
N2 - An understanding of the factors that place the posttransplant patient at increased risk for sinusitis would help identify patients likely to develop disease and possibly allow for interventions that would decrease the incidence or severity of sinus disease. This retrospective study investigates the ability of screening paranasal sinus computed tomographic scans (CTs), clinical history, and potential risk factors for sinusitis, including history of tobacco use, history of allergies or asthma, IgG level, history of sinusitis, remission status and acute graft-versus-host disease (GVHD) to predict post-transplant sinusitis. Medical records and sinus CTs of 100 allogeneic bone marrow recipients were reviewed. There was no increased risk of developing sinusitis post SCT for patients with significant disease on screening CT, symptoms at time of transplant, a history of tobacco use, asthma or allergies, low IgG level, history of sinusitis or for patients at high risk of relapse. Patients with GVHD were 4.3 times more likely than patients without GVHD to develop sinusitis post transplant (95% CI: 1.7-11.0, P = 0.002). Acute GVHD places patients at greater risk of developing sinus infections.
AB - An understanding of the factors that place the posttransplant patient at increased risk for sinusitis would help identify patients likely to develop disease and possibly allow for interventions that would decrease the incidence or severity of sinus disease. This retrospective study investigates the ability of screening paranasal sinus computed tomographic scans (CTs), clinical history, and potential risk factors for sinusitis, including history of tobacco use, history of allergies or asthma, IgG level, history of sinusitis, remission status and acute graft-versus-host disease (GVHD) to predict post-transplant sinusitis. Medical records and sinus CTs of 100 allogeneic bone marrow recipients were reviewed. There was no increased risk of developing sinusitis post SCT for patients with significant disease on screening CT, symptoms at time of transplant, a history of tobacco use, asthma or allergies, low IgG level, history of sinusitis or for patients at high risk of relapse. Patients with GVHD were 4.3 times more likely than patients without GVHD to develop sinusitis post transplant (95% CI: 1.7-11.0, P = 0.002). Acute GVHD places patients at greater risk of developing sinus infections.
KW - GVHD
KW - Sinusitis
KW - Stem cell transplant
UR - http://www.scopus.com/inward/record.url?scp=85047697973&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047697973&partnerID=8YFLogxK
U2 - 10.1038/sj.bmt.1703353
DO - 10.1038/sj.bmt.1703353
M3 - Article
C2 - 11859399
AN - SCOPUS:85047697973
SN - 0268-3369
VL - 29
SP - 257
EP - 261
JO - Bone marrow transplantation
JF - Bone marrow transplantation
IS - 3
ER -