Risk factors for mortality in AIDS-associated Kaposi sarcoma in a primary care antiretroviral treatment program in Malawi

Kathryn Chu; Dalitso Misinde; Moses Massaquoi; Olesi Pasulani; Beatrice Mwagomba; Nathan Ford; Rony Zachariah

doi:10.1016/j.inhe.2010.04.001

Risk factors for mortality in AIDS-associated Kaposi sarcoma in a primary care antiretroviral treatment program in Malawi

Kathryn Chu, Dalitso Misinde, Moses Massaquoi, Olesi Pasulani, Beatrice Mwagomba, Nathan Ford, Rony Zachariah

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

AIDS-associated Kaposi sarcoma (AIDS-KS) is the most common HIV-related malignancy. The majority of cases are found in sub-Saharan Africa. This retrospective cohort study describes characteristics of patients with AIDS-KS and factors associated with mortality in an antiretroviral treatment (ART) program in rural Malawi. Of 11 122 patients enrolled on ART, 830 (7%) had AIDS-KS. Patients with AIDS-KS were more likely to be lost to follow-up (22% versus 14%, P < 0.001) and showed a higher mortality (22% versus 10%, P < 0.001) compared to patients without AIDS-KS. A CD4 count ≤150 cells/μl, advanced stage AIDS-KS, and absence of bleomycin chemotherapy were associated with increased mortality. Earlier diagnosis and improved treatment of AIDS-KS are urgently needed in order to reduce mortality.

Original language	English (US)
Pages (from-to)	99-102
Number of pages	4
Journal	International health
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.inhe.2010.04.001
State	Published - Jun 2010
Externally published	Yes

Keywords

AIDS
Africa
Kaposi sarcoma
mortality
risk factors

ASJC Scopus subject areas

Health(social science)
Public Health, Environmental and Occupational Health

Access to Document

10.1016/j.inhe.2010.04.001

Cite this

@article{58ae3732bd9e46d4b4d3b7804d224dfb,

title = "Risk factors for mortality in AIDS-associated Kaposi sarcoma in a primary care antiretroviral treatment program in Malawi",

abstract = "AIDS-associated Kaposi sarcoma (AIDS-KS) is the most common HIV-related malignancy. The majority of cases are found in sub-Saharan Africa. This retrospective cohort study describes characteristics of patients with AIDS-KS and factors associated with mortality in an antiretroviral treatment (ART) program in rural Malawi. Of 11 122 patients enrolled on ART, 830 (7%) had AIDS-KS. Patients with AIDS-KS were more likely to be lost to follow-up (22% versus 14%, P < 0.001) and showed a higher mortality (22% versus 10%, P < 0.001) compared to patients without AIDS-KS. A CD4 count ≤150 cells/μl, advanced stage AIDS-KS, and absence of bleomycin chemotherapy were associated with increased mortality. Earlier diagnosis and improved treatment of AIDS-KS are urgently needed in order to reduce mortality.",

keywords = "AIDS, Africa, Kaposi sarcoma, mortality, risk factors",

author = "Kathryn Chu and Dalitso Misinde and Moses Massaquoi and Olesi Pasulani and Beatrice Mwagomba and Nathan Ford and Rony Zachariah",

year = "2010",

month = jun,

doi = "10.1016/j.inhe.2010.04.001",

language = "English (US)",

volume = "2",

pages = "99--102",

journal = "International health",

issn = "1876-3413",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Risk factors for mortality in AIDS-associated Kaposi sarcoma in a primary care antiretroviral treatment program in Malawi

AU - Chu, Kathryn

AU - Misinde, Dalitso

AU - Massaquoi, Moses

AU - Pasulani, Olesi

AU - Mwagomba, Beatrice

AU - Ford, Nathan

AU - Zachariah, Rony

PY - 2010/6

Y1 - 2010/6

N2 - AIDS-associated Kaposi sarcoma (AIDS-KS) is the most common HIV-related malignancy. The majority of cases are found in sub-Saharan Africa. This retrospective cohort study describes characteristics of patients with AIDS-KS and factors associated with mortality in an antiretroviral treatment (ART) program in rural Malawi. Of 11 122 patients enrolled on ART, 830 (7%) had AIDS-KS. Patients with AIDS-KS were more likely to be lost to follow-up (22% versus 14%, P < 0.001) and showed a higher mortality (22% versus 10%, P < 0.001) compared to patients without AIDS-KS. A CD4 count ≤150 cells/μl, advanced stage AIDS-KS, and absence of bleomycin chemotherapy were associated with increased mortality. Earlier diagnosis and improved treatment of AIDS-KS are urgently needed in order to reduce mortality.

AB - AIDS-associated Kaposi sarcoma (AIDS-KS) is the most common HIV-related malignancy. The majority of cases are found in sub-Saharan Africa. This retrospective cohort study describes characteristics of patients with AIDS-KS and factors associated with mortality in an antiretroviral treatment (ART) program in rural Malawi. Of 11 122 patients enrolled on ART, 830 (7%) had AIDS-KS. Patients with AIDS-KS were more likely to be lost to follow-up (22% versus 14%, P < 0.001) and showed a higher mortality (22% versus 10%, P < 0.001) compared to patients without AIDS-KS. A CD4 count ≤150 cells/μl, advanced stage AIDS-KS, and absence of bleomycin chemotherapy were associated with increased mortality. Earlier diagnosis and improved treatment of AIDS-KS are urgently needed in order to reduce mortality.

KW - AIDS

KW - Africa

KW - Kaposi sarcoma

KW - mortality

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=77953104817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953104817&partnerID=8YFLogxK

U2 - 10.1016/j.inhe.2010.04.001

DO - 10.1016/j.inhe.2010.04.001

M3 - Article

C2 - 24037469

AN - SCOPUS:77953104817

SN - 1876-3413

VL - 2

SP - 99

EP - 102

JO - International health

JF - International health

IS - 2

ER -

Risk factors for mortality in AIDS-associated Kaposi sarcoma in a primary care antiretroviral treatment program in Malawi

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this