Risk factors for mortality in AIDS-associated Kaposi sarcoma in a primary care antiretroviral treatment program in Malawi

Kathryn Chu, Dalitso Misinde, Moses Massaquoi, Olesi Pasulani, Beatrice Mwagomba, Nathan Ford, Rony Zachariah

Research output: Contribution to journalArticlepeer-review

Abstract

AIDS-associated Kaposi sarcoma (AIDS-KS) is the most common HIV-related malignancy. The majority of cases are found in sub-Saharan Africa. This retrospective cohort study describes characteristics of patients with AIDS-KS and factors associated with mortality in an antiretroviral treatment (ART) program in rural Malawi. Of 11 122 patients enrolled on ART, 830 (7%) had AIDS-KS. Patients with AIDS-KS were more likely to be lost to follow-up (22% versus 14%, P < 0.001) and showed a higher mortality (22% versus 10%, P < 0.001) compared to patients without AIDS-KS. A CD4 count ≤150 cells/μl, advanced stage AIDS-KS, and absence of bleomycin chemotherapy were associated with increased mortality. Earlier diagnosis and improved treatment of AIDS-KS are urgently needed in order to reduce mortality.

Original languageEnglish (US)
Pages (from-to)99-102
Number of pages4
JournalInternational health
Volume2
Issue number2
DOIs
StatePublished - Jun 2010

Keywords

  • AIDS
  • Africa
  • Kaposi sarcoma
  • mortality
  • risk factors

ASJC Scopus subject areas

  • Health(social science)
  • Public Health, Environmental and Occupational Health

Fingerprint

Dive into the research topics of 'Risk factors for mortality in AIDS-associated Kaposi sarcoma in a primary care antiretroviral treatment program in Malawi'. Together they form a unique fingerprint.

Cite this