Risk factors for fungemia in children infected with human immunodeficiency virus: A case-control study

Corina E. Gonzalez, David Venzon, Sondra Lee, Brigitta U. Mueller, Phillip A. Pizzo, Thomas J. Walsh

Research output: Contribution to journalArticle

Abstract

To define the risk factors related to the occurrence of fungemia in children infected with human immunodeficiency virus (HIV), we performed a matched case-control study. During a 6-year period (1987-1993), fungemia developed in 22 (6.3%) of 347 HIV-infected children observed at the Pediatric Branch of the National Cancer Institute. Each of these 22 cases was matched by age and gender with three controls. Multiple logistic regression indicated that the best predictor of fungemia in this population was the presence of a central venous catheter placed for >90 days (P <.00001), followed by a group of risk factors composed of 10 independent variables adjusted for a CD4 cell count of <100/μL (p <.045). Those variables included treatment with more than three antibiotics, treatment with more than three parenteral antibiotics, >30 days of antibiotic treatment, bacterial infections, >30 days in the hospital, hypoalbuminemia, C3 (Centers for Disease Control and Prevention) classification of HIV infection, and malnourishment. We conclude that prolonged placement of central venous catheters is the most important risk factor for fungemia in HIV-infected children and that the risk of fungemia is further influenced by antibacterial therapy, catheter manipulation, and host response.

Original languageEnglish (US)
Pages (from-to)515-521
Number of pages7
JournalClinical Infectious Diseases
Volume23
Issue number3
StatePublished - 1996
Externally publishedYes

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Fungemia
Case-Control Studies
HIV
Central Venous Catheters
Musculoskeletal Manipulations
Hypoalbuminemia
National Cancer Institute (U.S.)
Virus Diseases
Centers for Disease Control and Prevention (U.S.)
Bacterial Infections
Malnutrition
Catheters
Logistic Models
Pediatrics
Anti-Bacterial Agents
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Gonzalez, C. E., Venzon, D., Lee, S., Mueller, B. U., Pizzo, P. A., & Walsh, T. J. (1996). Risk factors for fungemia in children infected with human immunodeficiency virus: A case-control study. Clinical Infectious Diseases, 23(3), 515-521.

Risk factors for fungemia in children infected with human immunodeficiency virus : A case-control study. / Gonzalez, Corina E.; Venzon, David; Lee, Sondra; Mueller, Brigitta U.; Pizzo, Phillip A.; Walsh, Thomas J.

In: Clinical Infectious Diseases, Vol. 23, No. 3, 1996, p. 515-521.

Research output: Contribution to journalArticle

Gonzalez, CE, Venzon, D, Lee, S, Mueller, BU, Pizzo, PA & Walsh, TJ 1996, 'Risk factors for fungemia in children infected with human immunodeficiency virus: A case-control study', Clinical Infectious Diseases, vol. 23, no. 3, pp. 515-521.
Gonzalez, Corina E. ; Venzon, David ; Lee, Sondra ; Mueller, Brigitta U. ; Pizzo, Phillip A. ; Walsh, Thomas J. / Risk factors for fungemia in children infected with human immunodeficiency virus : A case-control study. In: Clinical Infectious Diseases. 1996 ; Vol. 23, No. 3. pp. 515-521.
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