TY - JOUR
T1 - Risk factors for drug allergy
AU - Adkinson, N. Franklin
PY - 1984/10
Y1 - 1984/10
N2 - Judging from available data on penicillin allergy there appear to be multiple definable risk factors for drug-induced immunopathology. The induction of a drug-specific immune response can be influenced by the age of the patient; underlying genetic or metabolic factors, which may restrict ability to initiate a drug-specific immune response; the chemical properties of the drug, largely its protein reactivity; and the dose and duration of treatment as well as the route of drug administration. The elicitation of drug-induced immunopathology is a function of the persistence of a drug-specific immune response; the frequency of drug treatment and its dose and duration; and probable constitutional factors that may determine in an important way the efficiency with which a drug-specific immune response can be translated into a systemic allergic reaction.
AB - Judging from available data on penicillin allergy there appear to be multiple definable risk factors for drug-induced immunopathology. The induction of a drug-specific immune response can be influenced by the age of the patient; underlying genetic or metabolic factors, which may restrict ability to initiate a drug-specific immune response; the chemical properties of the drug, largely its protein reactivity; and the dose and duration of treatment as well as the route of drug administration. The elicitation of drug-induced immunopathology is a function of the persistence of a drug-specific immune response; the frequency of drug treatment and its dose and duration; and probable constitutional factors that may determine in an important way the efficiency with which a drug-specific immune response can be translated into a systemic allergic reaction.
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U2 - 10.1016/0091-6749(84)90108-8
DO - 10.1016/0091-6749(84)90108-8
M3 - Article
C2 - 6491103
AN - SCOPUS:0021678794
SN - 0091-6749
VL - 74
SP - 567
EP - 572
JO - The Journal of allergy and clinical immunology
JF - The Journal of allergy and clinical immunology
IS - 4 PART 2
ER -