Risk factors for development of new-onset diabetes mellitus after kidney transplantation

Tariq Shah, Arjang Kasravi, Edmund Huang, Rick Hayashi, Brian Young, Yong W. Cho, Suphamai Bunnapradist

Research output: Contribution to journalArticle

Abstract

BACKGROUND. New-onset diabetes mellitus after kidney transplantation (NODM) is an important co morbid condition that is associated with inferior graft and patient survival. The objective of this study was to identify donor, recipient and transplant factors, and choices of immunosuppression associated with development of NODM using Organ Procurement Transplant Network/United Network of Organ Sharing database (OPTN/UNOS). METHODS. From January 2004 to December 2005, 15,309 adult kidney transplants alone with at least one follow-up report as of March 2006 were identified in the OPTN/UNOS database. Among these, 1,581 patients developed NODM during the follow-up period. We examined the risk factors of NODM using multivariate Cox regression analysis using the time to diagnosis of NODM as a time-varying end point. Other events such as graft loss, patient death, and lost to follow-up were censored. RESULTS. NODM was reported in 10% in our study population with mean follow-up time of 306 days. After adjusting for other known factors, independent factors associated with the development of NODM included recipient age (29% increase of relative risk [RR] for every 10-year age increment), obesity (RR=1.39 for body mass index [BMI] 25-30 and RR=1.85 for BMI>30 vs. BMI

Original languageEnglish (US)
Pages (from-to)1673-1676
Number of pages4
JournalTransplantation
Volume82
Issue number12
DOIs
StatePublished - Dec 2006
Externally publishedYes

Fingerprint

Kidney Transplantation
Diabetes Mellitus
Transplants
Body Mass Index
Tissue and Organ Procurement
Databases
Lost to Follow-Up
Graft Survival
Immunosuppression
Obesity
Regression Analysis
Tissue Donors
Kidney
Population

Keywords

  • Diabetes mellitus
  • Kidney transplant
  • Outcomes
  • Post transplant complications

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Shah, T., Kasravi, A., Huang, E., Hayashi, R., Young, B., Cho, Y. W., & Bunnapradist, S. (2006). Risk factors for development of new-onset diabetes mellitus after kidney transplantation. Transplantation, 82(12), 1673-1676. https://doi.org/10.1097/01.tp.0000250756.66348.9a

Risk factors for development of new-onset diabetes mellitus after kidney transplantation. / Shah, Tariq; Kasravi, Arjang; Huang, Edmund; Hayashi, Rick; Young, Brian; Cho, Yong W.; Bunnapradist, Suphamai.

In: Transplantation, Vol. 82, No. 12, 12.2006, p. 1673-1676.

Research output: Contribution to journalArticle

Shah, T, Kasravi, A, Huang, E, Hayashi, R, Young, B, Cho, YW & Bunnapradist, S 2006, 'Risk factors for development of new-onset diabetes mellitus after kidney transplantation', Transplantation, vol. 82, no. 12, pp. 1673-1676. https://doi.org/10.1097/01.tp.0000250756.66348.9a
Shah, Tariq ; Kasravi, Arjang ; Huang, Edmund ; Hayashi, Rick ; Young, Brian ; Cho, Yong W. ; Bunnapradist, Suphamai. / Risk factors for development of new-onset diabetes mellitus after kidney transplantation. In: Transplantation. 2006 ; Vol. 82, No. 12. pp. 1673-1676.
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