Risk factors for coronary heart disease in African Americans

The Atherosclerosis Risk in Communities Study, 1987-1997

Daniel W. Jones, Lloyd E. Chambless, Aaron R. Folsom, Gerardo Heiss, Richard G. Hutchinson, A. Richey Sharrett, Moyses Szklo, Herman A. Taylor

Research output: Contribution to journalArticle

Abstract

Background: As part of the Atherosclerosis Risk in Communities Study, the race-specific incidence rates and risk factor prediction for coronary heart disease (CHD) were determined for black and white persons over 7 to 10 years of follow-up, from 1987 to 1997. Methods: The sample included 14 062 men and women (2298 black women, 5686 white women, 1396 black men, and 4682 white men) aged 45 to 64 years who were free of clinical CHD at baseline. Results: Average age-adjusted incidence rates (95% confidence intervals) for CHD per 1000 person-years were as follows: black women, 5.1 (4.2-6.2); white women, 4.0 (3.5-4.6); black men, 10.6 (8.9-12.7); and white men, 12.5 (11.5-13.7). Incidence rates (95% confidence intervals) using a definition for CHD that excluded revascularization procedures were as follows: black women, 4.9 (4.6-6.0); white women, 2.9 (2.5-3.4); black men, 9.2 (7.6-11.1); and white men, 7.9 (7.0-8.8). In a multivariable analysis, hypertension was a particularly strong risk factor in black women, with hazard rate ratios (95% confidence intervals) as follows: black women, 4.8 (2.5-9.0); white women, 2.1 (1.6-2.9); black men, 2.0 (1.3-3.0); and white men, 1.6 (1.3-1.9). Diabetes mellitus was somewhat more predictive in white women than in other groups. Hazard rate ratios (95% confidence intervals) were as follows: black women, 1.8 (1.2-2.8); white women, 3.3 (2.4-4.6); black men, 1.6 (1.1-2.5); and white men, 2.0 (1.6-2.6). Low-density lipoprotein cholesterol level was similarly predictive in all race-sex groups (hazard rate ratio, 1.2-1.4 per SD increment of low-density lipoprotein cholesterol level). High-density lipoprotein cholesterol level seemed somewhat more protective in white than in black persons. Conclusions: Findings from this study, along with clinical trial evidence showing efficacy, support aggressive management of traditional risk factors in black persons, as in white persons. Understanding the intriguing racial differences in risk factor prediction may be an important part of further elucidating the causes of CHD and may lead to better methods of preventing and treating CHD.

Original languageEnglish (US)
Pages (from-to)2565-2571
Number of pages7
JournalArchives of Internal Medicine
Volume162
Issue number22
DOIs
StatePublished - Dec 9 2002

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African Americans
Coronary Disease
Atherosclerosis
Confidence Intervals
LDL Cholesterol
Incidence
HDL Cholesterol
Diabetes Mellitus
Clinical Trials
Hypertension

ASJC Scopus subject areas

  • Internal Medicine

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Jones, D. W., Chambless, L. E., Folsom, A. R., Heiss, G., Hutchinson, R. G., Sharrett, A. R., ... Taylor, H. A. (2002). Risk factors for coronary heart disease in African Americans: The Atherosclerosis Risk in Communities Study, 1987-1997. Archives of Internal Medicine, 162(22), 2565-2571. https://doi.org/10.1001/archinte.162.22.2565

Risk factors for coronary heart disease in African Americans : The Atherosclerosis Risk in Communities Study, 1987-1997. / Jones, Daniel W.; Chambless, Lloyd E.; Folsom, Aaron R.; Heiss, Gerardo; Hutchinson, Richard G.; Sharrett, A. Richey; Szklo, Moyses; Taylor, Herman A.

In: Archives of Internal Medicine, Vol. 162, No. 22, 09.12.2002, p. 2565-2571.

Research output: Contribution to journalArticle

Jones, DW, Chambless, LE, Folsom, AR, Heiss, G, Hutchinson, RG, Sharrett, AR, Szklo, M & Taylor, HA 2002, 'Risk factors for coronary heart disease in African Americans: The Atherosclerosis Risk in Communities Study, 1987-1997', Archives of Internal Medicine, vol. 162, no. 22, pp. 2565-2571. https://doi.org/10.1001/archinte.162.22.2565
Jones, Daniel W. ; Chambless, Lloyd E. ; Folsom, Aaron R. ; Heiss, Gerardo ; Hutchinson, Richard G. ; Sharrett, A. Richey ; Szklo, Moyses ; Taylor, Herman A. / Risk factors for coronary heart disease in African Americans : The Atherosclerosis Risk in Communities Study, 1987-1997. In: Archives of Internal Medicine. 2002 ; Vol. 162, No. 22. pp. 2565-2571.
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abstract = "Background: As part of the Atherosclerosis Risk in Communities Study, the race-specific incidence rates and risk factor prediction for coronary heart disease (CHD) were determined for black and white persons over 7 to 10 years of follow-up, from 1987 to 1997. Methods: The sample included 14 062 men and women (2298 black women, 5686 white women, 1396 black men, and 4682 white men) aged 45 to 64 years who were free of clinical CHD at baseline. Results: Average age-adjusted incidence rates (95{\%} confidence intervals) for CHD per 1000 person-years were as follows: black women, 5.1 (4.2-6.2); white women, 4.0 (3.5-4.6); black men, 10.6 (8.9-12.7); and white men, 12.5 (11.5-13.7). Incidence rates (95{\%} confidence intervals) using a definition for CHD that excluded revascularization procedures were as follows: black women, 4.9 (4.6-6.0); white women, 2.9 (2.5-3.4); black men, 9.2 (7.6-11.1); and white men, 7.9 (7.0-8.8). In a multivariable analysis, hypertension was a particularly strong risk factor in black women, with hazard rate ratios (95{\%} confidence intervals) as follows: black women, 4.8 (2.5-9.0); white women, 2.1 (1.6-2.9); black men, 2.0 (1.3-3.0); and white men, 1.6 (1.3-1.9). Diabetes mellitus was somewhat more predictive in white women than in other groups. Hazard rate ratios (95{\%} confidence intervals) were as follows: black women, 1.8 (1.2-2.8); white women, 3.3 (2.4-4.6); black men, 1.6 (1.1-2.5); and white men, 2.0 (1.6-2.6). Low-density lipoprotein cholesterol level was similarly predictive in all race-sex groups (hazard rate ratio, 1.2-1.4 per SD increment of low-density lipoprotein cholesterol level). High-density lipoprotein cholesterol level seemed somewhat more protective in white than in black persons. Conclusions: Findings from this study, along with clinical trial evidence showing efficacy, support aggressive management of traditional risk factors in black persons, as in white persons. Understanding the intriguing racial differences in risk factor prediction may be an important part of further elucidating the causes of CHD and may lead to better methods of preventing and treating CHD.",
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N2 - Background: As part of the Atherosclerosis Risk in Communities Study, the race-specific incidence rates and risk factor prediction for coronary heart disease (CHD) were determined for black and white persons over 7 to 10 years of follow-up, from 1987 to 1997. Methods: The sample included 14 062 men and women (2298 black women, 5686 white women, 1396 black men, and 4682 white men) aged 45 to 64 years who were free of clinical CHD at baseline. Results: Average age-adjusted incidence rates (95% confidence intervals) for CHD per 1000 person-years were as follows: black women, 5.1 (4.2-6.2); white women, 4.0 (3.5-4.6); black men, 10.6 (8.9-12.7); and white men, 12.5 (11.5-13.7). Incidence rates (95% confidence intervals) using a definition for CHD that excluded revascularization procedures were as follows: black women, 4.9 (4.6-6.0); white women, 2.9 (2.5-3.4); black men, 9.2 (7.6-11.1); and white men, 7.9 (7.0-8.8). In a multivariable analysis, hypertension was a particularly strong risk factor in black women, with hazard rate ratios (95% confidence intervals) as follows: black women, 4.8 (2.5-9.0); white women, 2.1 (1.6-2.9); black men, 2.0 (1.3-3.0); and white men, 1.6 (1.3-1.9). Diabetes mellitus was somewhat more predictive in white women than in other groups. Hazard rate ratios (95% confidence intervals) were as follows: black women, 1.8 (1.2-2.8); white women, 3.3 (2.4-4.6); black men, 1.6 (1.1-2.5); and white men, 2.0 (1.6-2.6). Low-density lipoprotein cholesterol level was similarly predictive in all race-sex groups (hazard rate ratio, 1.2-1.4 per SD increment of low-density lipoprotein cholesterol level). High-density lipoprotein cholesterol level seemed somewhat more protective in white than in black persons. Conclusions: Findings from this study, along with clinical trial evidence showing efficacy, support aggressive management of traditional risk factors in black persons, as in white persons. Understanding the intriguing racial differences in risk factor prediction may be an important part of further elucidating the causes of CHD and may lead to better methods of preventing and treating CHD.

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