TY - JOUR
T1 - Risk factors for ckd progression overview of findings from the cric study
AU - Hannan, Mary
AU - Ansari, Sajid
AU - Meza, Natalie
AU - Anderson, Amanda H.
AU - Srivastava, Anand
AU - Waikar, Sushrut
AU - Charleston, Jeanne
AU - Weir, Matthew R.
AU - Taliercio, Jonathan
AU - Horwitz, Edward
AU - Saunders, Milda R.
AU - Wolfrum, Katherine
AU - Feldman, Harold I.
AU - Lash, James P.
AU - Ricardo, Ana C.
N1 - Funding Information:
The content is solely the responsibility of the author(s) and does not necessarily represent the official views of the NIH. The views expressed here do not necessarily reflect the views of the Robert Wood Johnson Foundation. Funding for the CRIC Study was obtained under a cooperative agreement from the NIDDK under grants U01DK060990, U01DK060984, U01DK061022, U01DK061021, U01DK061028, U01DK060980, U01DK060963, U01DK060902, and U24DK060990. In addition, this work was supported in part by: the Perelman School of Medicine at the University of Pennsylvania Clinical and Translational Science Award NIH/NCATS UL1TR000003, Johns Hopkins University UL1 TR-000424, University of Maryland GCRC M01 RR-16500, Clinical and Translational Science Collaborative of Cleveland, UL1TR000439 from the National Center for Advancing Translational Sciences (NCATS) component of the National Institutes of Health and NIH roadmap for Medical Research, Michigan Institute for Clinical and Health Research (MICHR) UL1TR000433, University of Illinois at Chicago CTSA UL1RR029879, Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases P20 GM109036, Kaiser Permanente NIH/NCRR UCSF-CTSI UL1 RR-024131, Department of Internal Medicine, University of New Mexico School of Medicine Albuquerque, NM R01DK119199. M. Hannan has received National Heart, Lung, and Blood Institute award T32HL134634 as a T32 Postdoctoral Fellow. J. Lash is funded by NIDDK grants K24DK092290 and R01DK072231-91. A. Ricardo is funded by NIDDK grant R01DK118736. A. Srivastava is funded by NIDDK grant K23DK120811.
Funding Information:
Funding for the CRIC Study was obtained under a cooperative agreement from the NIDDK under grants U01DK060990, U01DK060984, U01DK061022, U01DK061021, U01DK061028, U01DK060980, U01DK060963, U01DK060902, and U24DK060990. In addition, this work was supported in part by: the Perelman School of Medicine at the University of Pennsylvania Clinical and Translational Science Award NIH/NCATS UL1TR000003, Johns Hopkins University UL1 TR-000424, University of Maryland GCRC M01 RR-16500, Clinical and Translational Science Collaborative of Cleveland, UL1TR000439 from the National Center for Advancing Translational Sciences (NCATS) component of the National Institutes of Health and NIH roadmap for Medical Research, Michigan Institute for Clinical and Health Research (MICHR) UL1TR000433, University of Illinois at Chicago CTSA UL1RR029879, Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases P20 GM109036, Kaiser Per-manente NIH/NCRR UCSF-CTSI UL1 RR-024131, Department of Internal Medicine, University of New Mexico School of Medicine Albuquerque, NM R01DK119199. M. Hannan has received National Heart, Lung, and Blood Institute award T32HL134634 as a T32 Postdoctoral Fellow. J. Lash is funded by NIDDK grants K24DK092290 and R01DK072231-91. A. Ricardo is funded by NIDDK grant R01DK118736. A. Srivastava is funded by NIDDK grant K23DK120811.
Publisher Copyright:
© 2021 by the American Society of Nephrology.
PY - 2021
Y1 - 2021
N2 - The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter, longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD progression. This review summarizes findings from longitudinal studies evaluating risk factors associated with CKD progression in the CRIC Study, grouped into the following six thematic categories: (1) sociodemographic and economic (sex, race/ethnicity, and nephrology care); (2) behavioral (healthy lifestyle, diet, and sleep); (3) genetic (apoL1, genome-wide association study, and renin-angiotensin-aldosterone system pathway genes); (4) cardiovascular (atrial fibrillation, hypertension, and vascular stiffness); (5) metabolic (fibroblast growth factor 23 and urinary oxalate); and (6) novel factors (AKI and biomarkers of kidney injury). Additionally, we highlight areas where future research is needed, and opportunities for interdisciplinary collaboration.
AB - The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter, longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD progression. This review summarizes findings from longitudinal studies evaluating risk factors associated with CKD progression in the CRIC Study, grouped into the following six thematic categories: (1) sociodemographic and economic (sex, race/ethnicity, and nephrology care); (2) behavioral (healthy lifestyle, diet, and sleep); (3) genetic (apoL1, genome-wide association study, and renin-angiotensin-aldosterone system pathway genes); (4) cardiovascular (atrial fibrillation, hypertension, and vascular stiffness); (5) metabolic (fibroblast growth factor 23 and urinary oxalate); and (6) novel factors (AKI and biomarkers of kidney injury). Additionally, we highlight areas where future research is needed, and opportunities for interdisciplinary collaboration.
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U2 - 10.2215/CJN.07830520
DO - 10.2215/CJN.07830520
M3 - Article
C2 - 33177074
AN - SCOPUS:85104048064
VL - 16
SP - 648
EP - 659
JO - Clinical journal of the American Society of Nephrology : CJASN
JF - Clinical journal of the American Society of Nephrology : CJASN
SN - 1555-9041
IS - 4
ER -