TY - JOUR
T1 - Risk factors for ckd progression overview of findings from the cric study
AU - Hannan, Mary
AU - Ansari, Sajid
AU - Meza, Natalie
AU - Anderson, Amanda H.
AU - Srivastava, Anand
AU - Waikar, Sushrut
AU - Charleston, Jeanne
AU - Weir, Matthew R.
AU - Taliercio, Jonathan
AU - Horwitz, Edward
AU - Saunders, Milda R.
AU - Wolfrum, Katherine
AU - Feldman, Harold I.
AU - Lash, James P.
AU - Ricardo, Ana C.
N1 - Publisher Copyright:
© 2021 by the American Society of Nephrology.
PY - 2021
Y1 - 2021
N2 - The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter, longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD progression. This review summarizes findings from longitudinal studies evaluating risk factors associated with CKD progression in the CRIC Study, grouped into the following six thematic categories: (1) sociodemographic and economic (sex, race/ethnicity, and nephrology care); (2) behavioral (healthy lifestyle, diet, and sleep); (3) genetic (apoL1, genome-wide association study, and renin-angiotensin-aldosterone system pathway genes); (4) cardiovascular (atrial fibrillation, hypertension, and vascular stiffness); (5) metabolic (fibroblast growth factor 23 and urinary oxalate); and (6) novel factors (AKI and biomarkers of kidney injury). Additionally, we highlight areas where future research is needed, and opportunities for interdisciplinary collaboration.
AB - The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter, longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD progression. This review summarizes findings from longitudinal studies evaluating risk factors associated with CKD progression in the CRIC Study, grouped into the following six thematic categories: (1) sociodemographic and economic (sex, race/ethnicity, and nephrology care); (2) behavioral (healthy lifestyle, diet, and sleep); (3) genetic (apoL1, genome-wide association study, and renin-angiotensin-aldosterone system pathway genes); (4) cardiovascular (atrial fibrillation, hypertension, and vascular stiffness); (5) metabolic (fibroblast growth factor 23 and urinary oxalate); and (6) novel factors (AKI and biomarkers of kidney injury). Additionally, we highlight areas where future research is needed, and opportunities for interdisciplinary collaboration.
UR - http://www.scopus.com/inward/record.url?scp=85104048064&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85104048064&partnerID=8YFLogxK
U2 - 10.2215/CJN.07830520
DO - 10.2215/CJN.07830520
M3 - Article
C2 - 33177074
AN - SCOPUS:85104048064
SN - 1555-9041
VL - 16
SP - 648
EP - 659
JO - Clinical Journal of the American Society of Nephrology
JF - Clinical Journal of the American Society of Nephrology
IS - 4
ER -