TY - JOUR
T1 - Risk Factors for CKD Progression
T2 - Overview of Findings from the CRIC Study
AU - CRIC Study Investigators
AU - Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
AU - Hannan, Mary
AU - Ansari, Sajid
AU - Meza, Natalie
AU - Anderson, Amanda H.
AU - Srivastava, Anand
AU - Waikar, Sushrut
AU - Charleston, Jeanne
AU - Weir, Matthew R.
AU - Taliercio, Jonathan
AU - Horwitz, Edward
AU - Saunders, Milda R.
AU - Wolfrum, Katherine
AU - Feldman, Harold I.
AU - Lash, James P.
AU - Ricardo, Ana C.
N1 - Publisher Copyright:
Copyright © 2021 by the American Society of Nephrology.
PY - 2021/4/7
Y1 - 2021/4/7
N2 - The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter, longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD progression. This review summarizes findings from longitudinal studies evaluating risk factors associated with CKD progression in the CRIC Study, grouped into the following six thematic categories: (1) sociodemographic and economic (sex, race/ethnicity, and nephrology care); (2) behavioral (healthy lifestyle, diet, and sleep); (3) genetic (apoL1, genome-wide association study, and renin-angiotensin-aldosterone system pathway genes); (4) cardiovascular (atrial fibrillation, hypertension, and vascular stiffness); (5) metabolic (fibroblast growth factor 23 and urinary oxalate); and (6) novel factors (AKI and biomarkers of kidney injury). Additionally, we highlight areas where future research is needed, and opportunities for interdisciplinary collaboration.
AB - The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter, longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD progression. This review summarizes findings from longitudinal studies evaluating risk factors associated with CKD progression in the CRIC Study, grouped into the following six thematic categories: (1) sociodemographic and economic (sex, race/ethnicity, and nephrology care); (2) behavioral (healthy lifestyle, diet, and sleep); (3) genetic (apoL1, genome-wide association study, and renin-angiotensin-aldosterone system pathway genes); (4) cardiovascular (atrial fibrillation, hypertension, and vascular stiffness); (5) metabolic (fibroblast growth factor 23 and urinary oxalate); and (6) novel factors (AKI and biomarkers of kidney injury). Additionally, we highlight areas where future research is needed, and opportunities for interdisciplinary collaboration.
KW - chronic kidney disease
KW - progression of chronic renal failure
KW - risk factors
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U2 - 10.2215/CJN.07830520
DO - 10.2215/CJN.07830520
M3 - Article
C2 - 33177074
AN - SCOPUS:85104048064
VL - 16
SP - 648
EP - 659
JO - Clinical journal of the American Society of Nephrology : CJASN
JF - Clinical journal of the American Society of Nephrology : CJASN
SN - 1555-9041
IS - 4
ER -