TY - JOUR
T1 - Risk Factors for Cardiovascular Events in Patients on Antidementia Medications
AU - He, Meiqi
AU - Stevenson, James M.
AU - Zhang, Yuting
AU - Hernandez, Inmaculada
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Alzheimer’s Association (Grant Number AARGD-17-500234). Dr Hernandez is funded by the National Heart, Lung and Blood Institute (Grant Number K01HL142847). Dr Stevenson is funded by the American Heart Association (Grant Number 17MCPRP33400176).
Publisher Copyright:
© The Author(s) 2020.
PY - 2020
Y1 - 2020
N2 - Objective: To identify characteristics associated with an increased risk of cardiovascular events in patients diagnosed with Alzheimer disease (AD) and treated with antidementia medications. Methods: Demographics, diagnoses, and medication usage of 30 433 Medicare patients were analyzed using 2006 to 2013 claims data and a combined model of screening, ranking and stepwise logistic regressions to evaluate factors associated with composite outcomes of 6 cardiovascular events. Results: Incidence rate of at least 1 cardiovascular event was 25.1%. Fifty-five factors were identified from the 10 381 candidate variables by the combined model with a c-statistic of 67% and an accuracy of 75%. Factors associated with increased risk of cardiovascular events include history of heart rhythm disorders, alteration of consciousness (odds ratio [OR]: 1.25; 95% confidence interval [CI]: 1.14-1.36), and usage of β-blockers (OR: 1.19; 95% CI: 1.13-1.27). Conclusions: Clinicians should consider the increased risk of cardiovascular events in patients with AD with heart rhythm disorders and on β-blockers.
AB - Objective: To identify characteristics associated with an increased risk of cardiovascular events in patients diagnosed with Alzheimer disease (AD) and treated with antidementia medications. Methods: Demographics, diagnoses, and medication usage of 30 433 Medicare patients were analyzed using 2006 to 2013 claims data and a combined model of screening, ranking and stepwise logistic regressions to evaluate factors associated with composite outcomes of 6 cardiovascular events. Results: Incidence rate of at least 1 cardiovascular event was 25.1%. Fifty-five factors were identified from the 10 381 candidate variables by the combined model with a c-statistic of 67% and an accuracy of 75%. Factors associated with increased risk of cardiovascular events include history of heart rhythm disorders, alteration of consciousness (odds ratio [OR]: 1.25; 95% confidence interval [CI]: 1.14-1.36), and usage of β-blockers (OR: 1.19; 95% CI: 1.13-1.27). Conclusions: Clinicians should consider the increased risk of cardiovascular events in patients with AD with heart rhythm disorders and on β-blockers.
KW - Medicare
KW - antidementia therapy
KW - cardiovascular event
KW - claims
KW - data mining
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U2 - 10.1177/1533317520922380
DO - 10.1177/1533317520922380
M3 - Article
C2 - 32383387
AN - SCOPUS:85084394646
SN - 1533-3175
VL - 35
JO - American Journal of Alzheimer's Disease and other Dementias
JF - American Journal of Alzheimer's Disease and other Dementias
ER -