Risk factors for autism: Perinatal factors, parental psychiatric history, and socioeconomic status

Heidi Jeanet Larsson, William W Eaton, Kreesten Meldgaard Madsen, Mogens Vestergaard, Anne Vingaard Olesen, Esben Agerbo, Diana Schendel, Poul Thorsen, Preben Bo Mortensen

Research output: Contribution to journalArticle

Abstract

Research suggests that heredity and early fetal development play a causal role in autism. This case-control study explored the association between perinatal factors, parental psychiatric history, socioeconomic status, and risk of autism. The study was nested within a cohort of all children born in Denmark after 1972 and at risk of being diagnosed with autism until December 1999. Prospectively recorded data were obtained from nationwide registries in Denmark. Cases totaled 698 children with a diagnosis of autism; each case was individually matched by gender, birth year, and age to 25 controls. Analyses by conditional logistic regression produced risk ratios and 95% confidence intervals. Adjusted analyses showed that the risk of autism was associated with breech presentation (risk ratio (RR) = 1.63, 95% confidence interval (CI): 1.18, 2.26), low Apgar score at 5 minutes (RR = 1.89, 95% CI: 1.10, 3.27), gestational age at birth

Original languageEnglish (US)
Pages (from-to)916-925
Number of pages10
JournalAmerican Journal of Epidemiology
Volume161
Issue number10
DOIs
StatePublished - May 15 2005

Fingerprint

Autistic Disorder
Social Class
Psychiatry
Odds Ratio
Confidence Intervals
Denmark
Parturition
Breech Presentation
Heredity
Apgar Score
Fetal Development
Gestational Age
Registries
Case-Control Studies
Logistic Models
Research

Keywords

  • Autistic disorder
  • Fetal growth retardation
  • Mental disorders
  • Parturition
  • Perinatology
  • Pregnancy outcome

ASJC Scopus subject areas

  • Epidemiology

Cite this

Larsson, H. J., Eaton, W. W., Madsen, K. M., Vestergaard, M., Olesen, A. V., Agerbo, E., ... Mortensen, P. B. (2005). Risk factors for autism: Perinatal factors, parental psychiatric history, and socioeconomic status. American Journal of Epidemiology, 161(10), 916-925. https://doi.org/10.1093/aje/kwi123

Risk factors for autism : Perinatal factors, parental psychiatric history, and socioeconomic status. / Larsson, Heidi Jeanet; Eaton, William W; Madsen, Kreesten Meldgaard; Vestergaard, Mogens; Olesen, Anne Vingaard; Agerbo, Esben; Schendel, Diana; Thorsen, Poul; Mortensen, Preben Bo.

In: American Journal of Epidemiology, Vol. 161, No. 10, 15.05.2005, p. 916-925.

Research output: Contribution to journalArticle

Larsson, HJ, Eaton, WW, Madsen, KM, Vestergaard, M, Olesen, AV, Agerbo, E, Schendel, D, Thorsen, P & Mortensen, PB 2005, 'Risk factors for autism: Perinatal factors, parental psychiatric history, and socioeconomic status', American Journal of Epidemiology, vol. 161, no. 10, pp. 916-925. https://doi.org/10.1093/aje/kwi123
Larsson, Heidi Jeanet ; Eaton, William W ; Madsen, Kreesten Meldgaard ; Vestergaard, Mogens ; Olesen, Anne Vingaard ; Agerbo, Esben ; Schendel, Diana ; Thorsen, Poul ; Mortensen, Preben Bo. / Risk factors for autism : Perinatal factors, parental psychiatric history, and socioeconomic status. In: American Journal of Epidemiology. 2005 ; Vol. 161, No. 10. pp. 916-925.
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