Risk factors for attention and behavioral issues in pediatric sickle cell disease

Research output: Contribution to journalArticle

Abstract

Background. Children with sickle cell disease have an increased risk of neurodevelopmental disorders such as attention deficit hyperactivity disorder, intellectual disability, and specific learning disabilities. Little research has been done to characterize the sickle cell disease-related characteristics associated with neurodevelopmental disorders in the sickle cell disease population. Methods. This study was a retrospective chart review involving the outpatient records of 2 medical centers, Kennedy Krieger Institute and Johns Hopkins Hospital. Participants in the study included 59 children with sickle cell disease with a documented neurodevelopmental diagnosis, specifically attention deficit hyperactivity disorder, attention issues, behavioral issues, executive dysfunction, specific learning disabilities in math, reading, and reading comprehension, intellectual disabilities, developmental delay, fine motor disorders, language disorders, or autism spectrum disorders. Results. Children with sickle cell disease type hemoglobin S-β thalassemia plus had significantly higher odds of attention issues than children with sickle cell disease type hemoglobin SS (OR = 17.0, 95% CI = 1.99-145.00, P

Original languageEnglish (US)
Pages (from-to)1087-1093
Number of pages7
JournalClinical Pediatrics
Volume54
Issue number11
DOIs
StatePublished - Oct 11 2015

Fingerprint

Sickle Cell Anemia
Pediatrics
Sickle Hemoglobin
Learning Disorders
Attention Deficit Disorder with Hyperactivity
Intellectual Disability
Language Disorders
Pervasive Child Development Disorders
beta-Thalassemia
Medical Records
Outpatients

Keywords

  • ADHD
  • neurodevelopmental disorders
  • sickle cell disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Risk factors for attention and behavioral issues in pediatric sickle cell disease. / Lance, Eboni I.; Comi, Anne M.; Johnston, Michael V.; Casella, James F.; Shapiro, Bruce K.

In: Clinical Pediatrics, Vol. 54, No. 11, 11.10.2015, p. 1087-1093.

Research output: Contribution to journalArticle

Lance, Eboni I.; Comi, Anne M.; Johnston, Michael V.; Casella, James F.; Shapiro, Bruce K. / Risk factors for attention and behavioral issues in pediatric sickle cell disease.

In: Clinical Pediatrics, Vol. 54, No. 11, 11.10.2015, p. 1087-1093.

Research output: Contribution to journalArticle

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