TY - JOUR
T1 - Risk factors for attention and behavioral issues in pediatric sickle cell disease
AU - Lance, Eboni I.
AU - Comi, Anne M.
AU - Johnston, Michael V.
AU - Casella, James F.
AU - Shapiro, Bruce K.
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: EIL was supported by T32HD007414-20 (Principal Investigator [PI] MVJ) from the National Institute of Child Health and Human Development (NICHD). EIL and JFC were supported by K12HL087169-07 (PI JFC) from the National Heart, Lung and Blood Institute (NHLBI). JFC was supported by U54HL090515 (PI JFC), R01HL091759 (PI JFC) from the NHLBI and U01-NS-042804 9 (PI Debaun) from the National Institute of Neurological Disorders and Stroke (NINDS). BKS was supported by LEND T73MC17245 from the Health Resources and Services Administration.
Publisher Copyright:
© 2015 SAGE Publications.
PY - 2015/10/11
Y1 - 2015/10/11
N2 - Background. Children with sickle cell disease have an increased risk of neurodevelopmental disorders such as attention deficit hyperactivity disorder, intellectual disability, and specific learning disabilities. Little research has been done to characterize the sickle cell disease-related characteristics associated with neurodevelopmental disorders in the sickle cell disease population. Methods. This study was a retrospective chart review involving the outpatient records of 2 medical centers, Kennedy Krieger Institute and Johns Hopkins Hospital. Participants in the study included 59 children with sickle cell disease with a documented neurodevelopmental diagnosis, specifically attention deficit hyperactivity disorder, attention issues, behavioral issues, executive dysfunction, specific learning disabilities in math, reading, and reading comprehension, intellectual disabilities, developmental delay, fine motor disorders, language disorders, or autism spectrum disorders. Results. Children with sickle cell disease type hemoglobin S-β thalassemia plus had significantly higher odds of attention issues than children with sickle cell disease type hemoglobin SS (OR = 17.0, 95% CI = 1.99-145.00, P <.02). Children with sickle cell disease and a reported history of asthma had significantly higher odds of behavioral issues than children with sickle cell disease without a history of asthma, after adjustment for gender and sickle cell disease type (exact OR = 19.53, 95% CI = 1.16-1369.72, P <.04). Conclusion. Children with sickle cell disease may have increased risk for certain neurodevelopmental diagnoses based on their disease characteristics and associated comorbidities. These preliminary study results should be explored in a larger database.
AB - Background. Children with sickle cell disease have an increased risk of neurodevelopmental disorders such as attention deficit hyperactivity disorder, intellectual disability, and specific learning disabilities. Little research has been done to characterize the sickle cell disease-related characteristics associated with neurodevelopmental disorders in the sickle cell disease population. Methods. This study was a retrospective chart review involving the outpatient records of 2 medical centers, Kennedy Krieger Institute and Johns Hopkins Hospital. Participants in the study included 59 children with sickle cell disease with a documented neurodevelopmental diagnosis, specifically attention deficit hyperactivity disorder, attention issues, behavioral issues, executive dysfunction, specific learning disabilities in math, reading, and reading comprehension, intellectual disabilities, developmental delay, fine motor disorders, language disorders, or autism spectrum disorders. Results. Children with sickle cell disease type hemoglobin S-β thalassemia plus had significantly higher odds of attention issues than children with sickle cell disease type hemoglobin SS (OR = 17.0, 95% CI = 1.99-145.00, P <.02). Children with sickle cell disease and a reported history of asthma had significantly higher odds of behavioral issues than children with sickle cell disease without a history of asthma, after adjustment for gender and sickle cell disease type (exact OR = 19.53, 95% CI = 1.16-1369.72, P <.04). Conclusion. Children with sickle cell disease may have increased risk for certain neurodevelopmental diagnoses based on their disease characteristics and associated comorbidities. These preliminary study results should be explored in a larger database.
KW - ADHD
KW - neurodevelopmental disorders
KW - sickle cell disease
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U2 - 10.1177/0009922815594356
DO - 10.1177/0009922815594356
M3 - Article
C2 - 26149844
AN - SCOPUS:84941552535
VL - 54
SP - 1087
EP - 1093
JO - Clinical Pediatrics
JF - Clinical Pediatrics
SN - 0009-9228
IS - 11
ER -