@article{936e8d5b961e4eae9c8c8daff0cc4033,
title = "Risk factors for antimicrobial resistance among Staphylococcus isolated from pets living with a patient diagnosed with methicillin-resistant Staphylococcus aureus infection",
abstract = "It has been suggested that pets play a critical role in the maintenance of methicillin-resistant (MR) and multidrug-resistant (MDR) Staphylococcus spp. in the household. We examined risk factors for carriage of antimicrobial-resistant coagulase-positive staphylococci, with particular attention to Staphylococcus aureus and Staphylococcus pseudintermedius isolated from pets living in households of people diagnosed with methicillin-resistant S. aureus (MRSA) skin or soft-tissue infection. We analyzed data collected cross-sectionally from a study conducted in 2012 that evaluated the transmission of MRSA and other staphylococci from humans, their pets and the environment (Pets and Environmental Transmission of Staphylococci [PETS] study). We used unadjusted and adjusted stratified logistic regression analyses with household-clustered standard errors to evaluate the association between demographic, healthcare-related, contact-related and environmental risk factors and MDR Staphylococcus spp. isolated from dogs and cats. Staphylococcal isolates obtained from dogs (n = 63) and cats (n = 47) were included in these analyses. The use of oral or injectable antimicrobials by the pets during the prior year was the main risk factor of interest. Based on our results, 50% (12/24) of S. aureus, 3.3% (1/30) of S. pseudintermedius and 25% (14/56) of other coagulase-positive staphylococci (CPS) were determined to be MDR. S. aureus isolates were more likely to be MDR compared with S. pseudintermedius. We did not find a significant statistical association between the use of oral or injectable antimicrobials in the prior year and the presence of MDR bacteria. The results suggest that drivers of antimicrobial resistance in household staphylococci may vary by bacterial species, which could have implications for one health intervention strategies for staphylococci and inform the investigation of other reverse zoonoses, such as COVID-19.",
keywords = "Staphylococcus, antimicrobial resistance, domestic animals, multidrug resistance",
author = "Cusi Ferradas and Caitlin Cotter and Shahbazian, {Jonathan H.} and Iverson, {Sally Ann} and Patrick Baron and Misic, {Ana M.} and Brazil, {Amy M.} and Rankin, {Shelley C.} and Irving Nachamkin and Ferguson, {Jacqueline M.} and Peng, {Roger D.} and Bilker, {Warren B.} and Ebbing Lautenbach and Morris, {Daniel O.} and Lescano, {Andr{\'e}s G.} and Davis, {Meghan F.}",
note = "Funding Information: Cusi Ferradas was supported by the Fogarty International Center of the National Institutes of Health (NIH) under Award Number D43TW009343 and the University of California Global Health Institute (UCGHI). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or UCGHI. This project or its parent study was supported by the Commonwealth Universal Research Enhancement (CURE) Program of the Pennsylvania Department of Health (to E.L.), the Johns Hopkins Center for a Livable Future (to M.F.D.), a Johns Hopkins Faculty Innovation grant (to M.F.D.), the Morris Animal Foundation (to M.F.D.) and the American College of Veterinary Dermatology/American Academy of Veterinary Dermatology (to D.O.M.). Investigators were supported by an NIAID K24 grant (AI080942 to E.L.), a postdoctoral fellowship on a NIEHS T32 grant (ES7141‐29 for M.F.D.) and an ORIP K01 grant (K01OD019918 to M.F.D.). This parent study was supported by a CDC cooperative agreement (FOA#CK11‐001, Epicenters for the Prevention of Healthcare Associated Infections). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or UCGHI. Funding Information: Cusi Ferradas was supported by the Fogarty International Center of the National Institutes of Health (NIH) under Award Number D43TW009343 and the University of California Global Health Institute (UCGHI). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or UCGHI. This project or its parent study was supported by the Commonwealth Universal Research Enhancement (CURE) Program of the Pennsylvania Department of Health (to E.L.), the Johns Hopkins Center for a Livable Future (to M.F.D.), a Johns Hopkins Faculty Innovation grant (to M.F.D.), the Morris Animal Foundation (to M.F.D.) and the American College of Veterinary Dermatology/American Academy of Veterinary Dermatology (to D.O.M.). Investigators were supported by an NIAID K24 grant (AI080942 to E.L.), a postdoctoral fellowship on a NIEHS T32 grant (ES7141-29 for M.F.D.) and an ORIP K01 grant (K01OD019918 to M.F.D.). This parent study was supported by a CDC cooperative agreement (FOA#CK11-001, Epicenters for the Prevention of Healthcare Associated Infections). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or UCGHI. We thank the study participants and study personnel, and the support of Francesca Schiaffino, Andree Valle and Carlos Culquichicon. This work was presented at the 2019 American Society of Tropical Medicine and Hygiene Conference (Ferradas et al., 2019). Publisher Copyright: {\textcopyright} 2022 The Authors. Zoonoses and Public Health published by Wiley-VCH GmbH.",
year = "2022",
month = aug,
doi = "10.1111/zph.12946",
language = "English (US)",
volume = "69",
pages = "550--559",
journal = "Zoonoses and Public Health",
issn = "1863-1959",
number = "5",
}