Risk factors for African tick-bite fever in rural central Africa

Lucy M. Ndip, Hope H. Biswas, Landry E. Nfonsam, Matthew LeBreton, Roland N. Ndip, Marie A. Bissong, Emmanuel Mpoudi-Ngole, Cyrille Djoko, Ubald Tamoufe, A. Tassy Prosser, Donald S. Burke, Nathan D. Wolfe

Research output: Contribution to journalArticle

Abstract

African tick-bite fever is an emerging infectious disease caused by the spotted fever group Rickettsia, Rickettsia africae, and is transmitted by ticks of the genus Amblyomma. To determine the seroprevalence of exposure to R. africae and risk factors associated with infection, we conducted a cross-sectional study of persons in seven rural villages in distinct ecological habitats of Cameroon. We examined 903 plasma samples by using an indirect immunofluorescence assay for antibodies to R. africae and analyzed demographic and occupational data collected from questionnaires. Of the 903 persons tested, 243 (26.9%) had IgG/IgM/IgA reactive with R. africae. Persons from four of the seven village sites were significantly more likely to be seropositive (P <0.05), and lowland forest sites tended to have higher seroprevalences. These results suggest that African tick-bite fever is common in adults in rural areas of Cameroon and that ecological factors may play a role in the acquisition of R. africae infection.

Original languageEnglish (US)
Pages (from-to)608-613
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume84
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Fingerprint

Tick Bites
Central Africa
Rickettsia
Cameroon
Fever
Seroepidemiologic Studies
Emerging Communicable Diseases
R Factors
Ticks
Indirect Fluorescent Antibody Technique
Infection
Immunoglobulin A
Ecosystem
Immunoglobulin M
Cross-Sectional Studies
Immunoglobulin G
Demography
Antibodies

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology
  • Medicine(all)

Cite this

Ndip, L. M., Biswas, H. H., Nfonsam, L. E., LeBreton, M., Ndip, R. N., Bissong, M. A., ... Wolfe, N. D. (2011). Risk factors for African tick-bite fever in rural central Africa. American Journal of Tropical Medicine and Hygiene, 84(4), 608-613. https://doi.org/10.4269/ajtmh.2011.10-0191

Risk factors for African tick-bite fever in rural central Africa. / Ndip, Lucy M.; Biswas, Hope H.; Nfonsam, Landry E.; LeBreton, Matthew; Ndip, Roland N.; Bissong, Marie A.; Mpoudi-Ngole, Emmanuel; Djoko, Cyrille; Tamoufe, Ubald; Prosser, A. Tassy; Burke, Donald S.; Wolfe, Nathan D.

In: American Journal of Tropical Medicine and Hygiene, Vol. 84, No. 4, 04.2011, p. 608-613.

Research output: Contribution to journalArticle

Ndip, LM, Biswas, HH, Nfonsam, LE, LeBreton, M, Ndip, RN, Bissong, MA, Mpoudi-Ngole, E, Djoko, C, Tamoufe, U, Prosser, AT, Burke, DS & Wolfe, ND 2011, 'Risk factors for African tick-bite fever in rural central Africa', American Journal of Tropical Medicine and Hygiene, vol. 84, no. 4, pp. 608-613. https://doi.org/10.4269/ajtmh.2011.10-0191
Ndip, Lucy M. ; Biswas, Hope H. ; Nfonsam, Landry E. ; LeBreton, Matthew ; Ndip, Roland N. ; Bissong, Marie A. ; Mpoudi-Ngole, Emmanuel ; Djoko, Cyrille ; Tamoufe, Ubald ; Prosser, A. Tassy ; Burke, Donald S. ; Wolfe, Nathan D. / Risk factors for African tick-bite fever in rural central Africa. In: American Journal of Tropical Medicine and Hygiene. 2011 ; Vol. 84, No. 4. pp. 608-613.
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