Risk factors, complication and measures to prevent or reverse catastrophic sodium overcorrection in chronic hyponatremia

Kamel A. Gharaibeh, Joseph Brewer, Mohit Agarwal, Tibor Fülöp

Research output: Contribution to journalReview article


Hyponatremia is the most common electrolyte disorder encountered in clinical practice. Patients who develop this condition for more than 48 hours are at risk for severe neurological sequelae if correction of the serum sodium occurs too rapidly. Certain medical disorders are known to place patients at an increased risk for rapid correction of serum sodium concentration. Large-volume polyuria in this setting is an ominous sign. For these patients, early identification of risk factors, close monitoring of serum sodium correction and the use of 5% dextrose with or without desmopressin to prevent or reverse overcorrection are important components of treatment.

Original languageEnglish (US)
Pages (from-to)170-175
Number of pages6
JournalAmerican Journal of the Medical Sciences
Issue number2
Publication statusPublished - Feb 26 2015
Externally publishedYes



  • Desmopressin
  • Hyponatremia
  • Osmotic demyelination syndrome
  • Polyuria
  • Syndrome of inappropriate antidiuretic hormone secretion

ASJC Scopus subject areas

  • Medicine(all)

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