Risk Factors and Medical Management of Vasospasm After Subarachnoid Hemorrhage

Christos Lazaridis, Neeraj Naval

Research output: Contribution to journalReview articlepeer-review


Vasospasm is a major cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage. This article reviews the risk factors for vasospasm; the various methods for diagnosing vasospasm including the conventional 4-vessel angiography, computed tomographic angiography, and computed tomographic perfusion; the methods to detect vasospasm before clinical onset (including transcranial Doppler ultrasonography); and the recent emergence of multimodality monitoring. A discussion of medical treatment options in the setting of vasospasm is also included; the prophylactic use of " neuroprotectants" such as nimodipine, statins, and magnesium and the role of hemodynamic augmentation in vasospasm amelioration, including the use of inotropic support in addition to traditional triple-H therapy, are discussed.

Original languageEnglish (US)
Pages (from-to)353-364
Number of pages12
JournalNeurosurgery clinics of North America
Issue number2
StatePublished - Apr 1 2010


  • Aneurysmal subarachnoid hemorrhage
  • Cerebral blood flow
  • Triple-H therapy
  • Vasospasm

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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