Risk factor differences for aortic versus coronary calcified atherosclerosis

The multiethnic study of atherosclerosis

Michael H. Criqui, Aruna Kamineni, Matthew A. Allison, Joachim H. Ix, Jeffrey J. Carr, Mary Cushman, Robert Detrano, Wendy S Post, Nathan D. Wong

Research output: Contribution to journalArticle

Abstract

OBJECTIVE-: The goal of this study was to compare and contrast coronary artery calcium (CAC) with abdominal aortic calcium (AAC) in terms of their associations with traditional and novel cardiovascular disease (CVD) risk factors. METHODS AND RESULTS-: We measured both AAC and CAC using computed tomography scans in 1974 men and women aged 45 to 84 years from a multiethnic cohort. Traditional and novel CVD risk factors were examined separately in relation to AAC and CAC, using logistic regression for qualitative categorical comparisons and multiple linear regression for quantitative continuous comparisons. AAC was significantly associated with cigarette smoking and dyslipidemia and showed no gender difference. In contrast, CAC showed much weaker associations with smoking and dyslipidemia and a strong male predominance. Age and hypertension were associated similarly and significantly with AAC and CAC. Novel risk factors generally showed no independent association with either calcium measure, although in subset analyses, phosphorus, but not calcium, was related to CAC. The receiver operating characteristic curves for the qualitative results and the r2 values for the quantitative analyses were both much higher for AAC than for CAC. CONCLUSION-: AAC showed stronger correlations with most CVD risk factors than did CAC. The predictive value of AAC compared with CAC for incident CVD events remains to be evaluated.

Original languageEnglish (US)
Pages (from-to)2289-2296
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume30
Issue number11
DOIs
StatePublished - Nov 2010

Fingerprint

Coronary Artery Disease
Atherosclerosis
Calcium
Coronary Vessels
Cardiovascular Diseases
Dyslipidemias
Smoking
ROC Curve
Phosphorus
Linear Models

Keywords

  • aortic diseases
  • atherosclerosis
  • calcification
  • epidemiology
  • risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Risk factor differences for aortic versus coronary calcified atherosclerosis : The multiethnic study of atherosclerosis. / Criqui, Michael H.; Kamineni, Aruna; Allison, Matthew A.; Ix, Joachim H.; Carr, Jeffrey J.; Cushman, Mary; Detrano, Robert; Post, Wendy S; Wong, Nathan D.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 30, No. 11, 11.2010, p. 2289-2296.

Research output: Contribution to journalArticle

Criqui, Michael H. ; Kamineni, Aruna ; Allison, Matthew A. ; Ix, Joachim H. ; Carr, Jeffrey J. ; Cushman, Mary ; Detrano, Robert ; Post, Wendy S ; Wong, Nathan D. / Risk factor differences for aortic versus coronary calcified atherosclerosis : The multiethnic study of atherosclerosis. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2010 ; Vol. 30, No. 11. pp. 2289-2296.
@article{4ee578fec3f344cca9b21532a497b4fa,
title = "Risk factor differences for aortic versus coronary calcified atherosclerosis: The multiethnic study of atherosclerosis",
abstract = "OBJECTIVE-: The goal of this study was to compare and contrast coronary artery calcium (CAC) with abdominal aortic calcium (AAC) in terms of their associations with traditional and novel cardiovascular disease (CVD) risk factors. METHODS AND RESULTS-: We measured both AAC and CAC using computed tomography scans in 1974 men and women aged 45 to 84 years from a multiethnic cohort. Traditional and novel CVD risk factors were examined separately in relation to AAC and CAC, using logistic regression for qualitative categorical comparisons and multiple linear regression for quantitative continuous comparisons. AAC was significantly associated with cigarette smoking and dyslipidemia and showed no gender difference. In contrast, CAC showed much weaker associations with smoking and dyslipidemia and a strong male predominance. Age and hypertension were associated similarly and significantly with AAC and CAC. Novel risk factors generally showed no independent association with either calcium measure, although in subset analyses, phosphorus, but not calcium, was related to CAC. The receiver operating characteristic curves for the qualitative results and the r2 values for the quantitative analyses were both much higher for AAC than for CAC. CONCLUSION-: AAC showed stronger correlations with most CVD risk factors than did CAC. The predictive value of AAC compared with CAC for incident CVD events remains to be evaluated.",
keywords = "aortic diseases, atherosclerosis, calcification, epidemiology, risk factors",
author = "Criqui, {Michael H.} and Aruna Kamineni and Allison, {Matthew A.} and Ix, {Joachim H.} and Carr, {Jeffrey J.} and Mary Cushman and Robert Detrano and Post, {Wendy S} and Wong, {Nathan D.}",
year = "2010",
month = "11",
doi = "10.1161/ATVBAHA.110.208181",
language = "English (US)",
volume = "30",
pages = "2289--2296",
journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Risk factor differences for aortic versus coronary calcified atherosclerosis

T2 - The multiethnic study of atherosclerosis

AU - Criqui, Michael H.

AU - Kamineni, Aruna

AU - Allison, Matthew A.

AU - Ix, Joachim H.

AU - Carr, Jeffrey J.

AU - Cushman, Mary

AU - Detrano, Robert

AU - Post, Wendy S

AU - Wong, Nathan D.

PY - 2010/11

Y1 - 2010/11

N2 - OBJECTIVE-: The goal of this study was to compare and contrast coronary artery calcium (CAC) with abdominal aortic calcium (AAC) in terms of their associations with traditional and novel cardiovascular disease (CVD) risk factors. METHODS AND RESULTS-: We measured both AAC and CAC using computed tomography scans in 1974 men and women aged 45 to 84 years from a multiethnic cohort. Traditional and novel CVD risk factors were examined separately in relation to AAC and CAC, using logistic regression for qualitative categorical comparisons and multiple linear regression for quantitative continuous comparisons. AAC was significantly associated with cigarette smoking and dyslipidemia and showed no gender difference. In contrast, CAC showed much weaker associations with smoking and dyslipidemia and a strong male predominance. Age and hypertension were associated similarly and significantly with AAC and CAC. Novel risk factors generally showed no independent association with either calcium measure, although in subset analyses, phosphorus, but not calcium, was related to CAC. The receiver operating characteristic curves for the qualitative results and the r2 values for the quantitative analyses were both much higher for AAC than for CAC. CONCLUSION-: AAC showed stronger correlations with most CVD risk factors than did CAC. The predictive value of AAC compared with CAC for incident CVD events remains to be evaluated.

AB - OBJECTIVE-: The goal of this study was to compare and contrast coronary artery calcium (CAC) with abdominal aortic calcium (AAC) in terms of their associations with traditional and novel cardiovascular disease (CVD) risk factors. METHODS AND RESULTS-: We measured both AAC and CAC using computed tomography scans in 1974 men and women aged 45 to 84 years from a multiethnic cohort. Traditional and novel CVD risk factors were examined separately in relation to AAC and CAC, using logistic regression for qualitative categorical comparisons and multiple linear regression for quantitative continuous comparisons. AAC was significantly associated with cigarette smoking and dyslipidemia and showed no gender difference. In contrast, CAC showed much weaker associations with smoking and dyslipidemia and a strong male predominance. Age and hypertension were associated similarly and significantly with AAC and CAC. Novel risk factors generally showed no independent association with either calcium measure, although in subset analyses, phosphorus, but not calcium, was related to CAC. The receiver operating characteristic curves for the qualitative results and the r2 values for the quantitative analyses were both much higher for AAC than for CAC. CONCLUSION-: AAC showed stronger correlations with most CVD risk factors than did CAC. The predictive value of AAC compared with CAC for incident CVD events remains to be evaluated.

KW - aortic diseases

KW - atherosclerosis

KW - calcification

KW - epidemiology

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=78149281770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78149281770&partnerID=8YFLogxK

U2 - 10.1161/ATVBAHA.110.208181

DO - 10.1161/ATVBAHA.110.208181

M3 - Article

VL - 30

SP - 2289

EP - 2296

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 11

ER -