TY - JOUR
T1 - Risk Assessment and Prevention of Corneal Complications after Lateral Skull Base Surgery
AU - Sharon, Jeffrey D.
AU - Kraus, Courtney L.
AU - Ehrenburg, Matthew
AU - Weinreich, Heather M.
AU - Francis, Howard W.
N1 - Publisher Copyright:
Copyright © 2016 Otology & Neurotology, Inc.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Objective: To analyze the rate of corneal complications after lateral skull base surgery, and the relative risk of each potential contributing factor. Study Design: Retrospective cohort study. Setting: Tertiary care center. Patients: Adult patients who had undergone lateral skull base surgery involving an otolaryngologist at our institution from 2007 to 2015. Intervention: None. Main Outcome Measure: Relative risk (RR) for each potential contributing factor to corneal complications. Results: Four hundred sixty nine patients met inclusion criteria. Of those, 35 developed mild exposure keratopathy, 13 developed moderate exposure keratopathy, and 5 developed severe exposure keratopathy. Age, sex, previous eye surgery, tumor side, and pathology were not significant predictors of keratopathy. Tumor size greater than 30 mm (RR 4.75), postoperative trigeminal palsy (RR 3.42), postoperative abducens palsy (RR 9.08), House-Brackman score 5-6 (RR 4.77), lagophthalmos (RR 11.85), ectropion (RR 4.29), and previous eye disease (RR 1.83) were all significantly associated with the development of corneal complications. On multivariate analysis, lagophthalmos, abducens palsy, and tumor size were independent predictors of keratopathy. Conclusions: There are several important risk factors for exposure keratopathy after lateral skull base surgery, and knowledge of these risk factors can help identify high-risk patients in whom early, aggressive preventative therapy is warranted.
AB - Objective: To analyze the rate of corneal complications after lateral skull base surgery, and the relative risk of each potential contributing factor. Study Design: Retrospective cohort study. Setting: Tertiary care center. Patients: Adult patients who had undergone lateral skull base surgery involving an otolaryngologist at our institution from 2007 to 2015. Intervention: None. Main Outcome Measure: Relative risk (RR) for each potential contributing factor to corneal complications. Results: Four hundred sixty nine patients met inclusion criteria. Of those, 35 developed mild exposure keratopathy, 13 developed moderate exposure keratopathy, and 5 developed severe exposure keratopathy. Age, sex, previous eye surgery, tumor side, and pathology were not significant predictors of keratopathy. Tumor size greater than 30 mm (RR 4.75), postoperative trigeminal palsy (RR 3.42), postoperative abducens palsy (RR 9.08), House-Brackman score 5-6 (RR 4.77), lagophthalmos (RR 11.85), ectropion (RR 4.29), and previous eye disease (RR 1.83) were all significantly associated with the development of corneal complications. On multivariate analysis, lagophthalmos, abducens palsy, and tumor size were independent predictors of keratopathy. Conclusions: There are several important risk factors for exposure keratopathy after lateral skull base surgery, and knowledge of these risk factors can help identify high-risk patients in whom early, aggressive preventative therapy is warranted.
KW - Acoustic neuroma
KW - Corneal complications
KW - Exposure keratopathy
KW - Facial nerve
KW - Facial palsy
KW - Lagophthalmos
KW - Vestibular schwannoma
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UR - http://www.scopus.com/inward/citedby.url?scp=84976315474&partnerID=8YFLogxK
U2 - 10.1097/MAO.0000000000001123
DO - 10.1097/MAO.0000000000001123
M3 - Article
C2 - 27348388
AN - SCOPUS:84976315474
SN - 1531-7129
VL - 37
SP - 1148
EP - 1154
JO - Otology and Neurotology
JF - Otology and Neurotology
IS - 8
ER -