Risk and protective factors for cognitive impairment in persons aged 85 years and older

Rosebud O. Roberts, Ruth H. Cha, Michelle M. Mielke, Yonas E. Geda, Bradley F. Boeve, Mary M. MacHulda, David S. Knopman, Ronald C. Petersen

Research output: Contribution to journalArticle

Abstract

Objective: To determine risk and protective factors for mild cognitive impairment (MCI) among persons 85 years and older. Methods: Participants in the population-based prospective Mayo Clinic Study of Aging were comprehensively evaluated at baseline and at 15 monthly intervals to determine incident MCI. At baseline, lifestyle factors in midlife and late life were assessed by self-reported questionnaire; vascular and comorbid conditions were abstracted from participants' medical records. Results: Of 256 participants who were cognitively normal at enrollment (median age 87.3 years, 62% women), 121 developed MCI at a median 4.1 years of follow-up. Predictors of MCI were APOE ε4 allele (hazard ratio [HR] 1.89; p 0.008), current depressive symptoms (HR 1.78; p 0.02), midlife onset of hypertension (HR 2.43; p 0.005), increasing number of vascular diseases (HR 1.13; p 0.02), and chronic conditions from the Charlson Comorbidity Index (HR 1.08; p 0.006). Models were adjusted for sex and education, with age as the time variable. The risk of MCI was reduced for participants who reported engagement in artistic (HR 0.27; p 0.03), craft (HR 0.55; p 0.02), and social (HR 0.45; p 0.005) activities in both midlife and late life, and in the use of a computer in late life (HR 0.47; p 0.008). Conclusions: Chronic disease burden increases risk of MCI, whereas certain lifestyle factors reduce risk in persons 85 years and older. This implies that preventive strategies for MCI may need to begin in midlife and should persist throughout late life.

Original languageEnglish (US)
Pages (from-to)1854-1861
Number of pages8
JournalNeurology
Volume84
Issue number18
DOIs
StatePublished - May 5 2015
Externally publishedYes

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Life Style
Sex Education
Cognitive Dysfunction
Protective Factors
Vascular Diseases
Medical Records
Blood Vessels
Comorbidity
Chronic Disease
Alleles
Depression
Hypertension
Population
Surveys and Questionnaires

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Roberts, R. O., Cha, R. H., Mielke, M. M., Geda, Y. E., Boeve, B. F., MacHulda, M. M., ... Petersen, R. C. (2015). Risk and protective factors for cognitive impairment in persons aged 85 years and older. Neurology, 84(18), 1854-1861. https://doi.org/10.1212/WNL.0000000000001537

Risk and protective factors for cognitive impairment in persons aged 85 years and older. / Roberts, Rosebud O.; Cha, Ruth H.; Mielke, Michelle M.; Geda, Yonas E.; Boeve, Bradley F.; MacHulda, Mary M.; Knopman, David S.; Petersen, Ronald C.

In: Neurology, Vol. 84, No. 18, 05.05.2015, p. 1854-1861.

Research output: Contribution to journalArticle

Roberts, RO, Cha, RH, Mielke, MM, Geda, YE, Boeve, BF, MacHulda, MM, Knopman, DS & Petersen, RC 2015, 'Risk and protective factors for cognitive impairment in persons aged 85 years and older', Neurology, vol. 84, no. 18, pp. 1854-1861. https://doi.org/10.1212/WNL.0000000000001537
Roberts RO, Cha RH, Mielke MM, Geda YE, Boeve BF, MacHulda MM et al. Risk and protective factors for cognitive impairment in persons aged 85 years and older. Neurology. 2015 May 5;84(18):1854-1861. https://doi.org/10.1212/WNL.0000000000001537
Roberts, Rosebud O. ; Cha, Ruth H. ; Mielke, Michelle M. ; Geda, Yonas E. ; Boeve, Bradley F. ; MacHulda, Mary M. ; Knopman, David S. ; Petersen, Ronald C. / Risk and protective factors for cognitive impairment in persons aged 85 years and older. In: Neurology. 2015 ; Vol. 84, No. 18. pp. 1854-1861.
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AU - Boeve, Bradley F.

AU - MacHulda, Mary M.

AU - Knopman, David S.

AU - Petersen, Ronald C.

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