Ring-enhancement in multiple sclerosis: Marker of disease severity

K. Morgen, N. O. Jeffries, R. Stone, R. Martin, N. D. Richert, J. A. Frank, H. F. McFarland

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Correlations between conventional MRI measures of disease activity and clinical disability in multiple sclerosis (MS) have been disappointing. Because ring-enhancing lesions may reflect a more destructive pathology, we tested their potential association with disease severity. We evaluated active lesions with regard to their enhancement pattern on serial magnetic resonance images in a cohort of 28 patients with relapsing-remitting MS. The percentage of ring-enhancing lesions correlated with EDSS, T2 lesion load and duration of disease and predicted the occurrence of relapses during the baseline period of observation as well as after 3 years of follow-up in multiple logistic regression analysis. The findings suggest that the pathological process reflected by ring-enhancing lesions may contribute to more severe clinical disease.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalMultiple Sclerosis
Issue number3
StatePublished - 2001
Externally publishedYes


  • Enhancement pattern
  • Magnetic resonance
  • Multiple sclerosis
  • Ring-enhancing lesions

ASJC Scopus subject areas

  • Clinical Neurology


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