Right ventricular structure is associated with the risk of heart failure and cardiovascular death

The multi-ethnic study of atherosclerosis (MESA)-right ventricle study

Steven M. Kawut, R. Graham Barr, Joao Lima, Amy Praestgaard, W. Craig Johnson, Harjit Chahal, Kofo O. Ogunyankin, Michael R. Bristow, Jorge R. Kizer, Harikrishna Tandri, David A. Bluemke

Research output: Contribution to journalArticle

Abstract

BACKGROUND-: Changes in right ventricular (RV) morphology are associated with morbidity and mortality in heart and lung disease. We examined the association of abnormal RV structure and function with the risk of heart failure or cardiovascular death in a population-based multiethnic sample free of clinical cardiovascular disease at baseline. METHODS AND RESULTS-: The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac magnetic resonance imaging on 5098 participants between 2000 and 2002 with follow-up for incident heart failure and cardiovascular death ("death") until January 2008. RV volumes and mass were available for 4204 participants. The study sample (n=4144) was 61.4±10.1 years old and 47.6% male. The presence of RV hypertrophy (increased RV mass) was associated with more than twice the risk of heart failure or death after adjustment for demographics, body mass index, education, C-reactive protein level, hypertension, and smoking status (hazard ratio, 2.52; 95% confidence interval, 1.55-4.10; P

Original languageEnglish (US)
Pages (from-to)1681-1688
Number of pages8
JournalCirculation
Volume126
Issue number14
DOIs
StatePublished - Oct 2 2012

Fingerprint

Heart Ventricles
Atherosclerosis
Heart Failure
Right Ventricular Hypertrophy
Right Ventricular Function
C-Reactive Protein
Lung Diseases
Heart Diseases
Body Mass Index
Cardiovascular Diseases
Smoking
Magnetic Resonance Imaging
Demography
Confidence Intervals
Hypertension
Morbidity
Education
Mortality
Population

Keywords

  • heart ventricles
  • hypertension, pulmonary
  • magnetic resonance imaging
  • pulmonary heart disease
  • survival

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Right ventricular structure is associated with the risk of heart failure and cardiovascular death : The multi-ethnic study of atherosclerosis (MESA)-right ventricle study. / Kawut, Steven M.; Barr, R. Graham; Lima, Joao; Praestgaard, Amy; Johnson, W. Craig; Chahal, Harjit; Ogunyankin, Kofo O.; Bristow, Michael R.; Kizer, Jorge R.; Tandri, Harikrishna; Bluemke, David A.

In: Circulation, Vol. 126, No. 14, 02.10.2012, p. 1681-1688.

Research output: Contribution to journalArticle

Kawut, Steven M. ; Barr, R. Graham ; Lima, Joao ; Praestgaard, Amy ; Johnson, W. Craig ; Chahal, Harjit ; Ogunyankin, Kofo O. ; Bristow, Michael R. ; Kizer, Jorge R. ; Tandri, Harikrishna ; Bluemke, David A. / Right ventricular structure is associated with the risk of heart failure and cardiovascular death : The multi-ethnic study of atherosclerosis (MESA)-right ventricle study. In: Circulation. 2012 ; Vol. 126, No. 14. pp. 1681-1688.
@article{852e1357be0542c4b7ffd8fa1b6f7250,
title = "Right ventricular structure is associated with the risk of heart failure and cardiovascular death: The multi-ethnic study of atherosclerosis (MESA)-right ventricle study",
abstract = "BACKGROUND-: Changes in right ventricular (RV) morphology are associated with morbidity and mortality in heart and lung disease. We examined the association of abnormal RV structure and function with the risk of heart failure or cardiovascular death in a population-based multiethnic sample free of clinical cardiovascular disease at baseline. METHODS AND RESULTS-: The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac magnetic resonance imaging on 5098 participants between 2000 and 2002 with follow-up for incident heart failure and cardiovascular death ({"}death{"}) until January 2008. RV volumes and mass were available for 4204 participants. The study sample (n=4144) was 61.4±10.1 years old and 47.6{\%} male. The presence of RV hypertrophy (increased RV mass) was associated with more than twice the risk of heart failure or death after adjustment for demographics, body mass index, education, C-reactive protein level, hypertension, and smoking status (hazard ratio, 2.52; 95{\%} confidence interval, 1.55-4.10; P",
keywords = "heart ventricles, hypertension, pulmonary, magnetic resonance imaging, pulmonary heart disease, survival",
author = "Kawut, {Steven M.} and Barr, {R. Graham} and Joao Lima and Amy Praestgaard and Johnson, {W. Craig} and Harjit Chahal and Ogunyankin, {Kofo O.} and Bristow, {Michael R.} and Kizer, {Jorge R.} and Harikrishna Tandri and Bluemke, {David A.}",
year = "2012",
month = "10",
day = "2",
doi = "10.1161/CIRCULATIONAHA.112.095216",
language = "English (US)",
volume = "126",
pages = "1681--1688",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "14",

}

TY - JOUR

T1 - Right ventricular structure is associated with the risk of heart failure and cardiovascular death

T2 - The multi-ethnic study of atherosclerosis (MESA)-right ventricle study

AU - Kawut, Steven M.

AU - Barr, R. Graham

AU - Lima, Joao

AU - Praestgaard, Amy

AU - Johnson, W. Craig

AU - Chahal, Harjit

AU - Ogunyankin, Kofo O.

AU - Bristow, Michael R.

AU - Kizer, Jorge R.

AU - Tandri, Harikrishna

AU - Bluemke, David A.

PY - 2012/10/2

Y1 - 2012/10/2

N2 - BACKGROUND-: Changes in right ventricular (RV) morphology are associated with morbidity and mortality in heart and lung disease. We examined the association of abnormal RV structure and function with the risk of heart failure or cardiovascular death in a population-based multiethnic sample free of clinical cardiovascular disease at baseline. METHODS AND RESULTS-: The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac magnetic resonance imaging on 5098 participants between 2000 and 2002 with follow-up for incident heart failure and cardiovascular death ("death") until January 2008. RV volumes and mass were available for 4204 participants. The study sample (n=4144) was 61.4±10.1 years old and 47.6% male. The presence of RV hypertrophy (increased RV mass) was associated with more than twice the risk of heart failure or death after adjustment for demographics, body mass index, education, C-reactive protein level, hypertension, and smoking status (hazard ratio, 2.52; 95% confidence interval, 1.55-4.10; P

AB - BACKGROUND-: Changes in right ventricular (RV) morphology are associated with morbidity and mortality in heart and lung disease. We examined the association of abnormal RV structure and function with the risk of heart failure or cardiovascular death in a population-based multiethnic sample free of clinical cardiovascular disease at baseline. METHODS AND RESULTS-: The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac magnetic resonance imaging on 5098 participants between 2000 and 2002 with follow-up for incident heart failure and cardiovascular death ("death") until January 2008. RV volumes and mass were available for 4204 participants. The study sample (n=4144) was 61.4±10.1 years old and 47.6% male. The presence of RV hypertrophy (increased RV mass) was associated with more than twice the risk of heart failure or death after adjustment for demographics, body mass index, education, C-reactive protein level, hypertension, and smoking status (hazard ratio, 2.52; 95% confidence interval, 1.55-4.10; P

KW - heart ventricles

KW - hypertension, pulmonary

KW - magnetic resonance imaging

KW - pulmonary heart disease

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=84867093689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867093689&partnerID=8YFLogxK

U2 - 10.1161/CIRCULATIONAHA.112.095216

DO - 10.1161/CIRCULATIONAHA.112.095216

M3 - Article

VL - 126

SP - 1681

EP - 1688

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 14

ER -