Right ventricular ejection fraction measured by first-pass intravenous krypton-81m: Reproducibility and comparison with technetium-99m

Dean Foster Wong, T. K. Natarajan, Warren Summer, Paul A. Tibbits, Thomas Beck, Daniel Koller, Wayne Kasecamp, James Lamb, Joseph Olynyk, Mary Sue Philp, Marshall Bryan, Henry N. Wagner

Research output: Contribution to journalArticle


Study of the effects of various diseases and therapeutic manipulation of pulmonary vascular resistance on the right ventricle has been restricted by methodologic limitations. The radioactive gas in solution, krypton-81m was used to study the right ventricle and the technique was compared with a technetium-99m method. In 22 subjects, first-pass krypton-81m right ventricular ejection fraction, acquired both in list mode and electrocardiogramgated frame mode, correlated well (r = 0.81 and 0.86, respectively, p <0.01) with that determined by technetium-99m first-pass studies over a broad range of ventricular function. The reproducibility of the technique was excellent (r = 0.84 and 0.95 for each acquisition mode, respectively). Krypton-81m first-pass studies provide accurate and reproducible estimates of right ventricular function. Use of krypton allows multiple measurements, with or without perturbations, over a short period of time.

Original languageEnglish (US)
Pages (from-to)776-780
Number of pages5
JournalThe American Journal of Cardiology
Issue number12
Publication statusPublished - Nov 1 1985


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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